Not exact matches
Using
gene - sequencing technology,
researchers established that the precise segment of the pup's DNA «
switched on» by the act of grooming was the part that controlled the future function of the hippocampus, which processes stress hormones.
In a study published in Neoplasia,
researchers at the Washington University School of Medicine created a map showing which
genes were
switched on and off in different parts of the tumor, providing a «signature» of these
switches throughout the genome.
Working with this hypothesis, the
researchers conducted a statistical analysis of the CX3CR1
gene in over 7000 schizophrenia and autism patients and healthy subjects, finding one mutant candidate, a single amino acid
switch from alanine to threonine, as a candidate marker for prediction.
Because the prion - forming protein identified in the study normally functions as a regulator of
gene activity, the
researchers say their discovery raises the possibility that when it
switches to a prion state, it could alter genetic expression and bacterial behavior.
Researchers are developing molecular
switches that can inactivate transplanted
genes, paving the way for safer
gene therapies.
Issued last March to
researchers at a little - known cotton seed company called Delta & Pine Land (D&PL) and the U.S. Department of Agriculture, the patent covers a technique for transferring three
genes along with their genetic on
switches into the seeds of genetically improved plants.
Potentially explaining why even healthy brains don't function well with age, Salk
researchers have discovered that
genes that are
switched on early in brain development to sever connections between neurons as the brain fine - tunes, are again activated in aging neuronal support cells called astrocytes.
In 2002 Joslin
researcher Steven Shoelson knew that salicylates block the action of a protein called NFkB, a genetic master
switch in the liver that helps launch a cascade of
genes that cause the chronic, low - grade inflammation associated with diabetes.
With chronically infected mice as their model, the
researchers used a new technology called ATAC - seq to map the regulatory regions of the genome — the sections of DNA involved in
switching genes on and off — in the animals» exhausted and functional CD8 + T cells.
To see if the
gene, Gp - 9, was really a
switch for social behavior, the
researchers raised fire ants in captivity.
A team of
researchers has developed a light - activated
switch that can turn
genes on and off in mammalian cells.
Researchers showed that the
genes turned on by the
switch remained active for several hours in several mammalian cell lines even after a short light pulse.
Writing online in the journal Molecular Cell, a team of
researchers from the University of Wisconsin - Madison describes new research helping tease out the mechanics of how the gut microbiome communicates with the cells of its host to
switch genes on and off.
The
researchers engineered a strain in which a Synechococcus
gene normally turned on during photosynthesis signals its activity by
switching on the
gene for luciferase, an enzyme from another bacterium that drives a light - emitting chemical reaction.
The
researchers used tools of epigenomic analysis to trace the specific epigenetic
switches controlling each of thousands of
genes in both mouse and human retinal cells as the cells progressed through development.
Researchers have identified many of Short - root's
gene targets, but weren't sure what controlled the Short - root master
switch itself to kick off the cascade.
Mind controls: Putting a light
switch in the brain With optogenetics,
researchers can implant optical fibres to control genetically modified animals — could
gene therapy bring it to humans?
Light played a key role in the experiment because it allowed the
researchers to
switch on
genes that they had added to the yeast cells.
The super-enhancers
switched on known cancer
genes, including
genes like ALK, MYC, SMO and OTX2 that are associated with medulloblastoma,
researchers reported.
Researchers have developed a set of genetic
switches that can be built into engineered organisms, to control the function of
genes they need to survive.
Writing online Nov. 23 in the journal Molecular Cell, a team of
researchers from the University of Wisconsin — Madison describes new research helping tease out the mechanics of how the gut microbiome communicates with the cells of its host to
switch genes on and off.
But the
researchers also put a copy of the Myd88
gene near a special «promoter» sequence of DNA that gets
switched on during early embryonic development.
RNA interference, something Kissler learned as a post-doc at MIT, is a process that uses strands of genetic material called RNA to inhibit the expressions of
genes — meaning
researchers can manually decide which
genes get turned on or off and when by using RNA to block the pathways that lead to the
genes»
switches.
To keep those residual toxin levels at bay, the
researchers included a second
gene in their kill
switch, which produces low levels of an anti-toxin that can neutralize small amounts of the toxin.
In the most detailed large - scale study to date of the proteins that package DNA,
researchers have mapped a family of
switches that turn
genes on and off.
With the complete sequence of the N. meningitidis genome in hand,
researchers can now choose to target
genes that lack
switch regions.
The
researchers believe noise could play a role, so they combine single - molecule analysis with time - lapse movies of individual cells to track random activity in many different
genes as the cells
switch states.
Researchers have identified anti-CRISPR proteins that can act as an off
switch for the
gene editing system, making it safer to use.
The
researchers found that portions of the FTO
gene were involved in
switching on a promoter of IRX3, which encodes a transcription factor and is highly conserved in mice, zebrafish, and humans.
Researchers in the US, China and Taiwan have developed a new systems biology model that mimics the process of wood formation, allowing scientists to predict the effects of
switching on and off the 21 (at least) pathway
genes involved in producing lignin, a primary component of wood.
The idea of «
switching off» the cause of Huntington's disease was one of the first thoughts that popped into
researchers» heads when the HD
gene was discovered in 1993.
Most of these
genes are silenced, or unexpressed, but the
researchers demonstrate that this
gene silencing can be
switched on and off frequently.
Researchers found that particles in exhaust from cars and trucks can cause epigenetic changes — alterations that affect how
genes are
switched on and off without changing the DNA sequence itself.
Using the extensive St. Jude genomic database,
researchers searched for other
genes that were abnormally
switched on in a virulent form of AML that is driven by an oncogene called MYCN.
Other
researchers postulate that the muscle volumizing effect of creatine might
switch on a
gene responsible for IGF - 1 production.
In September 2012
researchers announced they had identified the
gene that
switches between mackerel and classic tabby patterns.