Sentences with phrase «researchers transplanted the cells»

When the researchers transplanted the cells into mouse spinal cords, the interneurons sprouted and integrated with existing cells.

Using stem cells harvested from human bone marrow, researchers transplanted cells into mice modeling ALS and already showing disease symptoms.

Not exact matches

All these researchers did was transplant code into a living cell.

Researchers used stem cells to create retinal pigment epithelium cells, which were transplanted into a patient's retina (left) in an area depicted by the black circle.

Since the cancer cells in both types of tumors were the same, the researchers compared the noncancerous cells present in the induced and transplanted tumors to explore what might be causing the T cell apoptosis.

Previous researchers have also used cell transplant technologies to repair injured hearts, but these used CMs organized in two dimensions with a random, myofibril structure, which is different from natural heart tissue.

Targeting exhausted immune cells may change the prognosis for patients with acute myeloid leukemia (AML) relapse after a stem cell transplant, according to Penn State College of Medicine researchers.

Mice transplanted with cells grown from a patient suffering from Huntington's disease (HD) develop the clinical features and brain pathology of that patient, suggests a study published in the latest issue of Acta Neuropathologica by CHA University in Korea, in collaboration with researchers at Université Laval in Québec City, Canada.

Researchers at Dana - Farber / Boston Children's Cancer and Blood Disorders Center report promising outcomes from a clinical trial with patients with a rare form of bone marrow failure who received a hematopoietic stem cell transplant (HSCT) after pre-treatment with immunosuppressive drugs only.

Once the UCLA researchers had produced iPS cells that were free from Duchenne mutations, they differentiated the iPS cells into cardiac muscle and skeletal muscle cells and then transplanted the skeletal muscle cells into mice that had a genetic mutation in the dystrophin gene.

So García and collaborators, including Georgia Tech postdoctoral researcher and first author Jessica Weaver, set out to engineer a new approach to transplanting the cells.

After fishing stem cells from each individual's own blood, the researchers inserted a normal version of the ABCD1 gene into some of the cells and transplanted them back into the kids.

Diabetes researchers are considering various replacements for insulin injections: Transplanting new pancreatic islet cells that make insulin, coaxing the patient's own islets to regenerate, or treating diabetics early in the disease with immune - suppressing therapies to prevent their body from destroying the rest of their pancreatic islets.

Using the material and protein combination, the researchers evaluated multiple locations for implanting the islet cell clusters, the first time such a direct comparison of transplant sites has been made.

In a study recently published in the journal Nature Biotechnology, HSCI researchers at Harvard University and Massachusetts General Hospital (MGH), in collaboration with Boston Children's Hospital and Dana Farber Cancer Institute, have developed a non-toxic transplantation procedure using antibodies to specifically target blood stem cells in mice, an approach they hope will make blood stem cell transplants for these patients far less toxic.

The JDF Center for Islet Cell Transplantation will fund 32 researchers to focus on four main goals: Reversing the overactive immune response that kills islet cells; finding new sources for islet cell transplants, such as pigs or genetically engineered cells; persuading the body to accept the transplanted cells without immunosuppressive drugs that often trigger worse side effects than the disease; and overcoming the technical difficulties of transplantatCell Transplantation will fund 32 researchers to focus on four main goals: Reversing the overactive immune response that kills islet cells; finding new sources for islet cell transplants, such as pigs or genetically engineered cells; persuading the body to accept the transplanted cells without immunosuppressive drugs that often trigger worse side effects than the disease; and overcoming the technical difficulties of transplantatcell transplants, such as pigs or genetically engineered cells; persuading the body to accept the transplanted cells without immunosuppressive drugs that often trigger worse side effects than the disease; and overcoming the technical difficulties of transplantation.

Researchers have had some success in transplanting islet cells, but recipients require heavy doses of immune suppression.

Researchers can create iPSCs from a patient's blood or skin cells, and use these patient - specific cells to study diseases or even create new tissues that could be transplanted back into the patient as therapy.

For one thing, researchers learned that fetal T cells are, in fact, able to reject foreign invaders — whether a microbe or a cell transplant — more readily than thought.

Nonetheless, for the researchers, «The success of our cell engineering experiments, which make it possible to produce nerve cells in a controlled and unlimited manner, and to transplant them, is a world first.

«Researchers find new functions of blood cell protein in transplant.»

Researchers already envision transplanting ready - made embryonic stem cells back into people, providing cures for a huge range of diseases, from diabetes to paralysis to Alzheimer's.

Researchers infuse the patient with the organ donor's bone marrow in hopes that the donor's immune cells will teach the host to tolerate the transplant; donor immune cells that come along with the transplanted organ also, some contend, can teach tolerance.

The researchers then introduced the two strains into mice transplanted with a human immune system and watched in real time as HIV spread from one CD4 + helper T cell to another.

The conventional treatment, a drug called L - dopa, is only partly effective, so researchers have tried transplanting dopamine neurons into Parkinson's sufferers to replace the dying cells.

The researchers performed a literature search of MEDLINE, EMBASE and PsycINFO databases and also manually searched reference lists for original, randomized, controlled trials on animals that examined the association between IVD stem cell transplant and the change of disc height.

If researchers can unlock the secrets of this cellular process, therapies that replace diseased cells with healthy ones may one day be possible — brain - cell transplants to combat Alzheimer's, for instance, or even the creation of whole organs from scratch.

For the first time, stem cell researchers have succeeded in getting transplanted nerve cells to establish connections with other neurons to improve movement in paralyzed rats.

Next, the researchers transplanted metastasizing human colon cancer cells into a different set of mice.

To further test the dish - matured cells, the researchers transplanted them into diabetic mice.

As a result of the finding, researchers can also use Mauritian cynomolgus macaques to improve stem cell transplant outcomes for human patients with other blood - related conditions such as leukemia and sickle - cell disease.

Researchers have long used a different monkey species to research stem cell transplants, but that species» biological characteristics means it can't be reliably used to find good donor matches to mimic human stem transplants.

The researchers theorized that the transplanted cells induced changes in neighboring cells, leading to today's view of development as a series of cell - cell interactions.

Lacking the biological machinery of a cell, the genome itself is not alive, but it should be possible to create full - blown artificial life by transplanting it into a cell — which is the researchers» next step.

Researchers report today that they grew prostate glands — important for reproduction in male mammals — in mice using a single stem cell transplanted from the prostates of donor mice.

The treatment with the engineered immune cells, called CAR - T cell therapy, may work even better if doctors transplant a subset of immune cells known as memory T cells, researchers reported February 14...

One of the biggest challenges for medical researchers studying the effectiveness of stem cell therapies is that transplants or grafts of cells are often rejected by the hosts.

To answer this question of nature versus nurture, the researchers took cells that would grow to become chandelier cells in the hippocampus and transplanted them into the neocortex, and took cells that would grow to become neocortical chandelier cells and transplanted them to the hippocampus.

When they transplanted embryonic brain cells into mice that had already been conditioned to fear a sound, the researchers found these mice were significantly more responsive to extinction training.

The researchers say their next step is to transplant the cells into mice with spinal cord injuries to see if the V2a interneurons can help to restore movement after damage has occurred.

A new test may reveal which patients will respond to treatment for graft versus host disease (GVHD), an often life - threatening complication of stem cell transplants (SCT) used to treat leukemia and other blood disorders, according to a study led by researchers at the Icahn School of Medicine at Mount Sinai and published online today in the journal Lancet Haematology and in print in the January issue.

Now, researchers at the University of Missouri have shown that a new line of genetically modified pigs will host transplanted cells without the risk of rejection.

Nor was it possible to attract T cells into the tumor when the researchers transplanted non-activated eosinophils, which do not produce attractants, into the mice.

While transplantation of T cells alone had only little impact on tumor size in cancerous mice, the researchers achieved substantial regression of the cancer by transplanting both T cells and activated eosinophils.

Researchers in Germany have demonstrated that hematopoietic stem cell (HSC) transplants can be improved by treatments that temporarily prevent the stem cells from dying.

This feature would be critical for clinical uses, such as transplanting stem cells — with their defects corrected — back into patients, but the researchers emphasize that years of further study remain before such treatments might be possible.

To test the therapeutic potential of this approach, the researchers transplanted the stem cell - derived pituitary cells under the skin of rats whose pituitary gland had been surgical removed.

Based on their findings, the researchers want to find ways to selectively target immunosuppression in lung transplants, to encourage memory T cells to thrive while eliminating other T cells that harm transplanted lungs.

Today, at 56, Atala oversees 300 researchers and support personnel, including chemists, biologists and engineers divided into different teams working on cell therapy, a technology for what he calls partial transplants and the creation of new organs.

Researchers need to identify cells — possibly adult stem cells from the patient — that can reconstruct lung tissue without provoking attack by the immune system, the problem that plagues current transplant recipients.