Like a Texan who keeps his drawl after moving to California, adult cells reprogrammed to
resemble embryonic cells retain some signatures of the tissue from which they came.
Not exact matches
By analysing the early steps that precede tumor formation, Alexandra Van Keymeulen and colleagues found that expression of oncogenic Pik3ca reactivates a multilineage differentiation program in adult stem
cells that
resembles to an immature
embryonic state.
Other researchers grew organoids from induced pluripotent stem
cells, which
resemble embryonic stem
cells but are grown from adult
cells.
Researchers from the University of California, Berkeley, have found a way to reprogram mouse
embryonic stem
cells so that they exhibit developmental characteristics
resembling those of fertilized eggs, or zygotes.
Mouse
embryonic stem
cells were turned into something
resembling spermatids, the round
cells that mature into sperm, by Jiahao Sha of Nanjing Medical University in China and his team.
Both teams successfully used these to reprogramme skin
cells in a lab dish into
cells resembling embryonic stem
cells, which have the ability to turn into any tissue of the human body.
The research used skin samples from five men to create what are known as induced pluripotent stem
cells, which closely
resemble embryonic stem
cells in their ability to become nearly any tissue in the body.
To make an organoid,
cells are carefully coaxed to go through a process that
resembles embryonic development.
In this respect, EC
cells from teratocarcinomas
resemble embryonic stem (ES)
cells from normal animals, which scientists knew existed, but could not isolate.