Sentences with phrase «resistance gene by»

The proliferation in gut bacteria of these markers would require first the uptake of the functional resistance gene by a gut bacterium, and then a selective advantage for that bacterium to survive and multiply.

Not exact matches

And on the subject of public health, it is worth exploding the number one myth of anti-GM lobbyists that the antibiotic resistance genes carried by some GM crops might lead to devastating human epidemics if transferred to bacteria.

New research suggests it may be possible to restore susceptibility to antibiotics in superbugs by locating and inactivating genes that promote resistance.

By adding these new genes, genetic engineers hope the plant will express the traits associated with the genes, such as resistance to certain diseases or herbicides.

In particular, the PTPRF gene, which is known to suppress intracellular signals that are usually triggered by insulin binding to its receptor on the cell surface, may serve as a biomarker linking insulin resistance with insufficient milk supply.

The bacteria behind gonorrhoea readily acquire genes for resisting drugs and so from 2012, UK patients were given two antibiotics at once — azithromycin pills plus a ceftriaxone injection — so if bacteria acquired resistance to one, they would be killed by the other.

By combining understanding of resistance genes with knowledge of the pathogen, they hope to develop Desiree and Maris Piper varieties that can completely thwart attacks from late blight.

More worrisome, perhaps, is that Mackie pulled more resistance genes from his deepest test wells, suggesting that the genes percolated down toward the drinking water supplies used by surrounding communities.

And the genes needed for resistance may take their own toll, perhaps by shortening a mosquito's life span.

In experiments on cell cultures, both of these inhibitors succeeded in breaking various forms of the TKI resistance: including forms caused by additional mutations of the gene Bcr - Abl as well as those caused by large quantities of the protein Gab2.

The number of copies of the resistance gene varies among cultivars; a new method, developed by University of Illinois researchers, is able to efficiently quantify this variation for the first time.

So, it's not an issue of her possibly becoming infected by these parasites, but because there is usually a genetic basis [for] parasite resistance, she may be looking for good genes for her offspring to survive better.

More than three fourths of all current antibiotics used to treat human infections are produced by Actinobacteria, which at the same time carry antibiotic resistance genes.

But by investigating the DNA sequence around the resistance genes, the team figured out how the resistance genes transfer occurred through a new mechanism named «carry back,» where the pathogen basically has a primitive form of «sex» with the Actinobacterium and takes up its resistance genes after it dies.

All that has to happen is the genes that make her be choosier about this have to survive better till the next generation by showing up in babies that survive better because their resistance is perfect.

The object of the experiment is to mutate a gene in the bacteria, giving it antibiotic resistance, then prove it by dosing the cultures with antibiotics.

The reference genome from QMUL was used by scientists at University of York who discovered genes that are associated with greater resistance to ash dieback.

Researchers have been tracking the spread of artemisinin - resistant parasites first by looking for signs in patients, and later by using multiple mutations in the parasite's Kelch13, or K13, gene, as molecular markers for resistance.

When multidrug - resistant malaria was detected, researchers were initially handicapped by the lack of a marker for piperaquine resistance; now, they have one, the presence of multiple copies of the plasmepsin 2 gene.

«Gene drives likely to be foiled by rapid rise of resistance.»

This analysis, done on separate samples from the same patient, revealed that many of the affected genes confer advantages to cancer cells by, for example, enhancing cell migration or resistance to chemotherapy.

To find out if their guess was right, Levin, Schrag, and Perrot made some of the drug - resistant bugs susceptible again by replacing their resistance gene with a gene that conferred sensitivity.

By comparing differences in the gene that confers antibiotic resistance, as well as other pieces of DNA, the team determined that 70 % of their samples included just five bacterial strains.

The resistance gene, however, by changing the shape of the ribosome, succeeds in blocking the drug — but at the cost of slowing down protein output.

Viruses called bacteriophages can infect a bug and by chance whisk away its resistance gene and deposit it in another microbe.

In one experiment this year, a team led by another CRISPR pioneer, Feng Zhang of the Broad Institute in Cambridge, Massachusetts, targeted the 20,000 or so known human genes, turning them on one by one in groups of cells to identify those involved in resistance to a melanoma drug.

Now, a team led by microbiologist Tim Kunkel of The Rockefeller University in New York City has shown that at least two crops — lettuce and tobacco — can be engineered without using antibiotic resistance genes.

The scientists also found that the extract affects the gene expression of the bacteria, by repressing a number of genes linked with antibiotic resistance and virulence.

New gene drive approaches will be necessary to overcome the challenge posed by resistance, especially in genetically diverse, natural populations.

«By comparing the two timelines, we saw the appearance of each specific gene in the soil samples was consistent with the evolution of similar types of resistance in medicine.

The gene for methicillin resistance, for example, had been acquired by five separate strains in five different places.

They found that the phages from antibiotic - treated mice carried significantly higher numbers of bacterial drug - resistance genes than they would have carried by chance.

Led by Newcastle University, UK, the study also showed that the repeated use of animal manure and antibiotic substitutes can increase the capacity of soil bacteria to mobilise, or ready themselves, and acquire resistance genes to new antibiotics.

Bacteria can become resistant to the antibiotic either as the result of a spontaneous mutation or by picking up an appropriate «resistance gene» (which codes for a protein that confers resistance) from another bacterium via genetic exchange.

Researchers at the San Diego Supercomputer Center (SDSC) and the Moores Cancer Center at the University of California, San Diego, have described for the first time the molecular mechanism of cancer development caused by well - known «resistance» mutations in the gene called epidermal growth factor receptor (EGFR).

Simply incorporating the gene, known as Bt, into a plant gives it resistance to pests, without requiring periodic spraying by the farmer.

These crops, being embraced by big agriculture in the U.S., carry genes that imbue them with resistance to herbicides and lace their tissues with a bacterial toxin harmless to humans but fatal to pests that may try to feed on them.

Growing resistance to malaria drugs in Southeast Asia is caused by a single mutated gene inside the disease - causing Plasmodium falciparum parasite, according to a study led by David Fidock, PhD, professor of microbiology & immunology and of medical sciences (in medicine) at Columbia University Medical Center.

Hyperthermophilic composting, therefore, has the potential to make composting end products safer by reducing the abundance of unwanted antibiotic resistance genes.

The researchers, led by Dr Charles Wondji, used a wide range of methods to narrow down how the resistance works, finding a single mutation in the GSTe2 gene, which makes insects break down DDT so it's no longer toxic.

Researchers hope that by sequencing the Chinese chestnut genome, they may be able to identify genes that confer resistance to the blight.

Field reports suggest that not all K13 mutations are capable of causing resistance, and the genetic system developed by Dr. Fidock to study K13, based on DNA repair approaches that are being used in human gene therapy studies, will be critical in identifying real hot spots of resistance.

«It is incredibly tempting to assume that antibiotics are promoting the spread of resistance by increasing the rate at which bacteria share resistant genes with each other, but our research shows they often aren't.»

By adding a single gene from wheat, researchers have created fungus - resistant trees that pass their resistance on to their offspring and, hopefully, subsequent generations too (see «American chestnut set for genetically modified revival «-RRB-.

The researchers, including scientists from The Genome Institute at Washington University School of Medicine, presented the research titled, «Patient - derived xenograft study reveals endocrine therapy resistance of ER + breast cancer caused by distinct ESR1 gene aberrations.»

Previous research by Professor Keevil and Dr Warnes has proved copper's efficacy against norovirus, influenza and hospital superbugs, such as MRSA and Klebsiella, plus stopping the transfer of antibiotic resistance genes to other bacteria to create new superbugs.

In principle this discovery could revolutionize saline agriculture worldwide by laying the groundwork of understanding necessary to appropriately using salt resistance genes and gene networks in crops to enable them to grow in desert and saline environments.

By transferring only the genes necessary for disease resistance, Gray says the technique may leave the vine's other traits intact.

Companies selling Bt seeds hope to avoid that in part by designing plants that make more than one Bt toxin, but this strategy may not work if resistance to several toxins is tied to a single gene, says Tabashnik, who is now at the University of Arizona.

Farmers are also trying to thwart resistance by growing plants that lack the Bt toxins near their fields, cultivating populations of normal insects that could swamp the resistance genes, says Randy Deaton, a Bt researcher at Monsanto, which developed some Bt crops.