Sentences with phrase «resistance gene on»

But many of the microbes Chénier's team studied harbored a chlortetracycline resistance gene on plasmids, even after years without the antibiotic.

So for example, if one microbe is resistant to antibiotics and the other one isn't, if we let them have sex, maybe one of them will pass the resistance gene on to the other one and we can figure out where it is by seeing how long it takes for that gene to get from one microbe to the other.

Not exact matches

Microbes could load these donated genes together on a single piece of DNA, accelerating the spread of resistance even further.

And on the subject of public health, it is worth exploding the number one myth of anti-GM lobbyists that the antibiotic resistance genes carried by some GM crops might lead to devastating human epidemics if transferred to bacteria.

In particular, the PTPRF gene, which is known to suppress intracellular signals that are usually triggered by insulin binding to its receptor on the cell surface, may serve as a biomarker linking insulin resistance with insufficient milk supply.

The resistance genes bedeviling doctors had evidently passed through many intermediaries on their way from soil to critically ill patients.

«The rising level of integrons after 1990 in manured soil could indicate that through our efforts to reduce antibiotic resistance, we have unintentionally increased resistance gene exchange and more study is needed on the use of animal manure,» says Prof Graham from Newcastle University.

In experiments on cell cultures, both of these inhibitors succeeded in breaking various forms of the TKI resistance: including forms caused by additional mutations of the gene Bcr - Abl as well as those caused by large quantities of the protein Gab2.

As millions of tons of fishmeal are used every year with much of it sinking uneaten to the ocean floor, Jing Wang and colleagues wanted to see what its impact could be on the mariculture «resistome,» or collection of resistance genes.

The findings reported in the Cell Press journal Current Biology on May 8 add to evidence showing just how common and abundant those resistance genes really are in natural environments.

And the race is on to find a molecular marker for PPQ resistance, the equivalent of the K13 gene.

Based on the apparent geographic exclusivity of the two resistance genes, the scientists expected to find that bacteria from the two regions were genetically different.

However, the long - term effects of the daily bathing on the prevalence of the qacA / B genes that lead to resistance to CHG in MRSA isolates is largely unknown.

The former target, say, using gene editing techniques to inactivate HIV receptors and achieve resistance of blood cells to the virus (which Sangamo BioSciences is working on in clincial trials) is different than helping parents who both carry genes for Huntington's Disease to have a child that is free of the disease (a change to the genome that would be passed on to future generations and would likely not be very commonly needed).

But bacteria can pass on the genes for antibiotic resistance, so any source of resistance is concerning.

When they inserted those genes into crop genomes, through a technique called recombinant DNA, the plants were able to produce the protein for bug resistance on their own, eliminating the need to spray insecticide.

Five decades on from the appearance of the first MRSA, multiple MRSA lineages have emerged which have acquired different variants of the resistance gene.»

This analysis, done on separate samples from the same patient, revealed that many of the affected genes confer advantages to cancer cells by, for example, enhancing cell migration or resistance to chemotherapy.

In one experiment this year, a team led by another CRISPR pioneer, Feng Zhang of the Broad Institute in Cambridge, Massachusetts, targeted the 20,000 or so known human genes, turning them on one by one in groups of cells to identify those involved in resistance to a melanoma drug.

They found evidence that the drug turns on the gene that produces the protein «FOXO,» a master regulator of stress resistance in many organisms that is often central in longevity studies.

One of them was able to cause full - blown disease symptoms — tan spore - producing lesions on the leaves — on eight soybean lines, including two with multiple resistance genes.

Most resistance genes, in wheat and other plants, code for protein receptors located inside cells; the Stb6 gene codes for a receptor protein on the cell's surface.

Based on their gene - drug interaction map, the researchers predicted that mutations in two genes, called ARID1A and GPBP1, could contribute to ovarian cancer's ability to develop resistance to this class of drugs.

Reetta Satokari's group has an interesting ongoing project where they look at the effects of faecal microbiota transplant on antibiotic resistance genes detected in the patient's microbiota.

The genes encoding NDM - 1 and other antibiotic resistance factors are usually carried on plasmids — circular strands of DNA separate from the bacterial genome — making it easier for them to spread through populations.

Tackling antibiotic resistance on only one front is a waste of time because resistant genes are freely crossing environmental, agricultural and clinical boundaries, new research has shown.

These crops, being embraced by big agriculture in the U.S., carry genes that imbue them with resistance to herbicides and lace their tissues with a bacterial toxin harmless to humans but fatal to pests that may try to feed on them.

Plus, the sustained antibiotic onslaught supposedly ensures that any hardier, partially drug - resistant bacteria also succumb, and thus don't pass on «stepping - stone» genes leading to full - blown resistance.

In the September issue of G3, Cuomo et al. unveil the first whole - genome sequence of a clinical sample of C. krusei, providing leads on genes that may be important for the species» fluconazole resistance.

When they focused on genes involved in drug resistance, the group found that C. krusei differs from C. albicans; many of the sites that are often mutated in the target of azole drugs in resistant C. albicans are not mutated in C. krusei.

Field reports suggest that not all K13 mutations are capable of causing resistance, and the genetic system developed by Dr. Fidock to study K13, based on DNA repair approaches that are being used in human gene therapy studies, will be critical in identifying real hot spots of resistance.

By adding a single gene from wheat, researchers have created fungus - resistant trees that pass their resistance on to their offspring and, hopefully, subsequent generations too (see «American chestnut set for genetically modified revival «-RRB-.

Previous studies on natural resistance to malaria had implicated a section of human genome near to a cluster of receptor genes.

They also say they are concerned about the antibiotic resistance marker gene that the wheat contains, and assert that the researchers «are openly releasing a synthetic version of a compound that... has had no long - term health safety tests whatsoever for human consumption, or for its impacts on non-target species.»

«Natural resistance to malaria linked to variation in human red blood cell receptors: First study to identify protective effect of glycophorin gene rearrangements on malaria.»

New research in Physiological Reports shows that although both resistance and endurance exercises activate the PGC - 1α gene, the adaptation processes stimulated are not the same and depend on the type of exercise.

The impatient gene It's long been known that evolution sometimes happens very quickly — as in the development of resistance to antibiotics in bacteria — but the discovery that lizards on two islands in Croatia evolved significant differences in body type and social structure in the span of fewer than forty years is shocking enough to warrant publication in a top - shelf journal, Proceedings of the National Academy of Sciences USA.

Prof Bentzen from Dalhousie University said: «Although this study focused on MHC genes in vertebrates, the evolutionary dynamics described in it likely apply to other gene families, for example resistance genes and those which prevent self - fertilization in plants (self - incompatibility loci) that are caught up in their own evolutionary races.»

However, these genes are rarely found in bacteria outside the wastewater treatment plants, which suggests that — contrary to what was previously believed — the treatment plants do not pass on resistance genes to bacteria that are hazardous to people.

Both the carbapenem resistance and the colistin resistance genes are on separate plasmids, which means in principle they could spread to other bacteria.»

Liu's team however have identified MCR - 1, a resistance gene that is carried on a plasmid — a swappable circle of DNA that can be easily passed between bacteria.

These genes exist on plasmids, small segments of DNA that are capable of moving from one bacterium to another, potentially spreading antibiotic resistance to other bacterial species.

Although the sprayed fields had fewer larvae overall, those survivors were more likely to carry resistance genes, presumably because the double - whammy of Bt crops in neighboring rows and the added Bt spray increased the selection pressure on the insects.

The team collected and counted the larvae that grew on the crops and tracked whether the insects had inherited one or two copies of the resistance genes.

Probing the mechanism of heteroresistance, Weiss and his colleagues were able to see a signature of colistin resistance, in terms of genes turned on and off.

Noticing an odd resistance profile, first author Vincenzo Di Pilato, Ph.D., reanalyzed the genome data from the bacterium, and discovered the new gene, which is a variant on the colistin - resistant gene, mcr - 1.

Since around half the cases of malignant melanoma are driven by mutation in the BRAF gene, the team focused on combinations that might address intrinsic resistance to the BRAF inhibitor vemurafenib.

The Yale - led study performed whole exome sequencing ¬ — a technique for sequencing all the expressed genes in a genome ¬ — on TNBC tumors to identify mutations in specific genes or pathways that may indicate response or resistance to the standard of care, which is anthracycline / taxane (ACT) chemotherapy.

He agrees with Chénier about the need for more research on the spread of resistance genes from farms to the environment.

The results suggest that evolution of resistance in independent populations of killifish converges on the same target gene.