If the chicken coops of subsistence farmers are hot spots of
resistance gene transfer, he speculated that bacteria present in industrial farming operations — where chickens regularly receive antibiotics — would see even more pressure to share resistance genes.
But by investigating the DNA sequence around the resistance genes, the team figured out how
the resistance genes transfer occurred through a new mechanism named «carry back,» where the pathogen basically has a primitive form of «sex» with the Actinobacterium and takes up its resistance genes after it dies.
Not exact matches
With respect to antibiotic
resistance, this novelty can be induced and we can trace the novelty to particular mutations arising absent
gene transfer; i.e. the
genes which give rise the
resistance were not present prior to the mutation, they are new sequences and not simply the activation of dormant
genes.
And on the subject of public health, it is worth exploding the number one myth of anti-GM lobbyists that the antibiotic
resistance genes carried by some GM crops might lead to devastating human epidemics if
transferred to bacteria.
They note that targeting inflammation to treat infections offers an advantage over antibiotic therapy, as the former hinders
gene transfer and the evolution of pathogens, while the latter promotes bacterial evolution and, ultimately, antibiotic
resistance.
«When you contaminate a site with
resistance genes, those
genes can be
transferred into environmental organisms and actually increase the concentration of contamination.»
«We can't stop this
gene transfer, but when you know, which
resistance genes pathogens may harbor, you can personalize the antibiotic treatment.
«If you think of the conjugative
transfer of
resistance genes as bacterial sex, you have to think of tetracycline as the aphrodisiac,» she says.
Finally, the researchers found that the vancomycin - resistant enterococci (VRE) bacteria found in the untreated wastewater contains a
gene capable of
transferring vancomycin
resistance to other strains of bacteria.
And both bacteria displayed the very same
resistance gene — most likely it had been
transferred to them from bacteria living in the gastrointestinal tract.
«Dangerous bacteria found after sewer spills: Bacteria equipped with
genes that can
transfer antibiotic
resistance adds to a sewage spill's public health threat.»
We assume that phages acquire
resistance genes from already resistant bacteria and then
transfer those
genes to other bacteria,» says Hilbert.
Hilbert recommends to test therapeutic phages for their ability to
transfer resistance genes.
«Antibiotics don't promote swapping of
resistance genes: Bacterial
resistance spreads through population dynamics, not an increase in
gene transfers.»
Previous research by Professor Keevil and Dr Warnes has proved copper's efficacy against norovirus, influenza and hospital superbugs, such as MRSA and Klebsiella, plus stopping the
transfer of antibiotic
resistance genes to other bacteria to create new superbugs.
By
transferring only the
genes necessary for disease
resistance, Gray says the technique may leave the vine's other traits intact.
But bacteria in the animals» gut can also
transfer the
resistance genes to microbes harmful to humans.
Genetic engineers directly
transferred the
gene for the toxic protein into crops to give them built - in
resistance.
«This means disease - causing bacteria in chickens are at risk of sickening humans and
transferring their
resistance genes in the process.
Conjugation is the main route for horizontal
gene transfer in bacteria and is responsible for the spread of antibiotic
resistance.
Their first effort involves
transferring a
gene from jointed goatgrass, a wild relative of wheat, to confer
resistance to stripe rust.
... the argument that occasional
transfer of these particular
resistance genes from GM plants to bacteria would pose an unacceptable risk to human or animal health has little substance.
Integrons capture and disseminate
gene - cassettes; short circular pieces of DNA that may contain
resistance genes [35], and integrons associated with class 1 integrases are known to
transfer many forms of
resistance genes [36].
Epidemiological evidence has always suggested that
resistance arose around this period, when the mecA
gene encoding methicillin
resistance carried on an SCCmec element, was horizontally
transferred to an intrinsically sensitive strain of S. aureus.
Resistance genes and mechanisms of horizontal
gene transfer with a significantly different relative abundance between the Indian downstream and Swedish metagenomes.
Recently, exceptional environmental releases of antibiotics have been documented, but the effects on the promotion of
resistance genes and the potential for horizontal
gene transfer have yet received limited attention.
Background: Horizontal
transfer of mobile genetic elements (MGEs) that carry virulence and antimicrobial
resistance genes mediates the evolution of methicillin - resistant Staphylococcus aureus, and the emergence of new MRSA clones.
The utility of the
gene has not been fully determined but in the future researchers hope to clone the
gene and
transfer disease
resistance to other wheat varieties.
Resistance genes and mechanisms of horizontal
gene transfer with a significantly different relative abundance between the Indian upstream and Swedish metagenomes.
Bacteria can
transfer genes that confer antibiotic
resistance to one another.