Sentences with phrase «resistance genes changed»
The researchers then observed how the frequency of resistance genes changed over six generations of mosquitoes — a process, biologists refer to as «microevolution.»
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The advent of rice varieties bearing genes with resistance to the disease has changed the perception about the disease: the incorporation of host - plant resistance genes in rice varieties, their adoption and deployment in the world's main rice - producing environments is probably one of the most significant evidences of the role of plant pathology in agricultural development.
The former target, say, using gene editing techniques to inactivate HIV receptors and achieve resistance of blood cells to the virus (which Sangamo BioSciences is working on in clincial trials) is different than helping parents who both carry genes for Huntington's Disease to have a child that is free of the disease (a change to the genome that would be passed on to future generations and would likely not be very commonly needed).
The resistance gene, however, by changing the shape of the ribosome, succeeds in blocking the drug — but at the cost of slowing down protein output.
Even in the half or so of all diabetes cases that seem to be related to genes that have programmed a person's cells to need less fuel, exercise and moderate diet changes can work wonders if the progress of insulin resistance is noticed soon enough during regular checkups.
A rare, but synonymous, codon in alleles of a drug - resistance gene can change translation kinetics and so produce a conformationally distinct protein species.
«Even though the specific molecular changes that are found in PCB - resistant tomcod and killifish are different, in both species AHR2 seems to be one of the genes — possibly the major gene — that is responsible for the resistance,» Hahn said.
According to a related study, the genes behind this resistance are evolving rapidly to keep up with an ever - changing adversary.
They found that structural changes crank up the output of one of the genes by 50-fold, suggesting how such flies attain increased nicotine resistance.
We concluded that an expanded Revive & Restore, in partnership with biotech organizations, will be able to offer services that include Genetic Insight (DNA sequencing and analysis), Biobanking (tissue collection and cell culturing), Advanced Reproductive Services (cloning and germ - line transmission), and Genome Engineering (CRISPR, gene - drive, etc.) Applications include restoring genetic diversity, augmenting adaptation to climate change, conferring resistance to disease, and extirpating harmful invasive species.
Expert scientific opinion has repeatedly reaffirmed that the presence of antibiotic resistance genes in GM foods is unable to change the level of antibiotic resistance present in gut bacteria (Bennett PM and others 2004, EFSA 2004, Salyers A (n.d.), van den Eede and others 2004).
Our data suggest that changes in the expression of genes associated with drug resistance and cancer cell «stemness», induced by treatment with MIA - 602, lead to a significant reduction in the efflux capacity of drug resistant cells.
«We found that knocking this gene down resulted in changes in fatty acid and lipid metabolism that are reminiscent of what we see in insulin resistance and T2D.»
Therefore, these reference genomes can also enable further studies, such as identifying gene expression changes that explain multidrug resistance and host interaction.
The advent of rice varieties bearing genes with resistance to the disease has changed the perception about the disease: the incorporation of host - plant resistance genes in rice varieties, their adoption and deployment in the world's main rice - producing environments is probably one of the most significant evidences of the role of plant pathology in agricultural development.
No significant differences were seen between the normoxic and hypoxic anoikis - resistant populations collected from MCF7 cells and a single significant gene change (PIP) was seen in T47D (Table 1) suggesting that the CSC - enriched population remains virtually unchanged following hypoxic culture and the increase in MFC, HFC, and tumor initiating cells is, therefore, due to expansion of the population, perhaps by increased symmetric self - renewal of the CSC or de-differentiation of early progenitor cells, rather than simply the acquisition of anoikis resistance in non-CSC.
We are also examining how gene expression changes caused by chromatin modifier mutations interact with other commonly mutated pathways in urothelial cancers such as RTK - RAS - RAF and PI3K - AKT - MTOR to influence therapeutic response and resistance.
A network - based analysis found these genes were also coupled to that encoding dihydrofolate reductase, changes to which underlie trimethoprim resistance.
A gene screen revealed a number of genetic changes in the first (daughter) and third (great granddaughter) high - fat mice generations, including several linked to increased breast cancer in women, increased resistance to treatment, poor prognosis, and impaired anticancer immunity.
A current project that could benefit, for example, is work with collaborators that explores how gene frequencies change and how unique genetic events such as the evolution of partial malarial resistance evolved in inhabitants of the island of Sardinia.
Worse still is when agribusiness and geneticists change the seeds of grasses, with their genetic manipulations converting, for example, 4 - and - a-half-foot tall traditional wheat into 18 - inch tall high - yield semidwarf strains that now comprise 99 % of all wheat grown worldwide, or insert various genes for herbicide resistance, as in genetically modified corn.