Using high - throughput sequencing of DNA from river sediment up and downstream from the Indian treatment plant [11] we identified a high prevalence of
resistance genes from multiple classes of antibiotics.
... the argument that occasional transfer of these particular
resistance genes from GM plants to bacteria would pose an unacceptable risk to human or animal health has little substance.
Conclusions: MinION sequencing comprehensively identified pathogens and acquired
resistance genes from urine in a timeframe similar to PCR (4 h from sample to result).
She did her PhD research in a collaborative project involving Punjab Agricultural University and the John Innes Centre, UK, to deploy stripe and leaf rust
resistance genes from non-progenitor wild wheat in commercial cultivars.
Diverse and abundant antibiotic
resistance genes from mariculture sites of China's coastline — Quanxin Gao — Science of The Total Environment
Herbicide -
resistance genes from GM canola have turned up in wild, weedy mustard plants on roadsides in the United States, Canada and elsewhere.
He agrees with Chénier about the need for more research on the spread of
resistance genes from farms to the environment.
«We were happy to find that antibiotic
resistance genes from soil bacteria generally aren't poised to jump suddenly into pathogens,» Dantas said.
«We obtained a total of 36 antibiotic
resistance genes from the antibiotic - resistant E. coli.»
We assume that phages acquire
resistance genes from already resistant bacteria and then transfer those genes to other bacteria,» says Hilbert.
Ideally, they could insert
the resistance genes from Asian chestnuts into American ones.
The desire of the host to acquire antibiotic
resistance genes from its guest could have driven this chain of events, he says.
More worrisome, perhaps, is that Mackie pulled more
resistance genes from his deepest test wells, suggesting that the genes percolated down toward the drinking water supplies used by surrounding communities.
A concerning finding among the Brazilian hybrids was that one was 51 per cent earworm but included a known
resistance gene from the bollworm.
Not exact matches
The bacteria behind gonorrhoea readily acquire
genes for resisting drugs and so
from 2012, UK patients were given two antibiotics at once — azithromycin pills plus a ceftriaxone injection — so if bacteria acquired
resistance to one, they would be killed by the other.
Specifically, they have found unnaturally high levels of antibiotic
resistance genes in sediments where the river comes into contact with treated municipal wastewater effluent and farm irrigation runoff as it flows 126 miles
from Rocky Mountain National Park through Fort Collins and across Colorado's eastern plain, home to some of the country's most densely packed livestock operations.
No doctor wants to ignore an opportunity to save a patient
from infectious disease, yet much of what is prescribed is probably unnecessary — and all of it feeds the spread of
resistance genes in hospitals and apparently throughout the environment.
The
resistance genes bedeviling doctors had evidently passed through many intermediaries on their way
from soil to critically ill patients.
By combining understanding of
resistance genes with knowledge of the pathogen, they hope to develop Desiree and Maris Piper varieties that can completely thwart attacks
from late blight.
Over the past 60 years,
genes for antibiotic
resistance have gone
from rare to commonplace in the microbes that routinely infect our bodies.
But the rapid rise of bacterial
genes for drug
resistance stems
from more than lucky mutation, Levy adds.
Is the jump in
resistance genes coming
from a population explosion in the resistant enteric, or intestinal, bacteria coming into the sewage plant?
Sidney Altman and his colleagues at Yale University used one of the bacteria's own enzymes, called RNase P, to disable RNA made
from genes that had been linked to drug
resistance.
«The rising level of integrons after 1990 in manured soil could indicate that through our efforts to reduce antibiotic
resistance, we have unintentionally increased
resistance gene exchange and more study is needed on the use of animal manure,» says Prof Graham
from Newcastle University.
Nor would they be able to receive any
genes from natural bacteria that would endow them with antibiotic
resistance or the ability to make toxins.
Gene drive systems that use genetic approaches to kill mosquitoes, prevent them
from breeding, or stop them
from transmitting the malaria - causing parasite are under development, but a concern is that mosquitoes could evolve
resistance to these techniques, too.
The first transgenic crop likely to be put forward for approval for open trials and commercial release is Bt cotton — which has added
genes from the Bacillus thuringiensis bacterium, making the plant produce toxins that confer
resistance to some insect pests.
In the last three years, Byamukama and graduate student Krishna Acharya have collected soil samples
from 28 East River counties to determine which
resistance gene sources are still effective against the predominant races of Heterodera glycine, or soybean cyst nematode, in South Dakota.
Samples collected
from soil contained the most diverse pool of
resistance genes, the authors found.
For more than 30 years, scientists have proposed that
resistance genes actually originate
from the microorganisms producing the antibiotic.
We could get radiation -
resistance genes, for example,
from the Bdelloid rotifer, a class of small invertebrates that live in freshwater pools and survive megadoses of ionizing radiation.
Identifying where
resistance genes come
from and how they spread somewhat compares to finding patient zero in an outbreak, which is not an easy task.
Bacteria expressing enzyme in one cell (bright green), while genetically identical cells do not, remaining protected
from antibiotic onslaught; image courtesy of Yuichi Wakamoto / Neeraj Dhar / John McKinney Some strains of nasty bacterial infections, such as MRSA (methicillin - resistant Staphylococcus aureus), come loaded with
resistance to antibiotics built right into their
genes.
From isolated caves to ancient permafrost, antibiotic - resistant bacteria and
genes for
resistance have been showing up in unexpected places.
«We found that as more «mixing» occurs between local dust and that which comes
from far off, the lower the contribution of the imported antibiotic
resistance genes.»
Based on the apparent geographic exclusivity of the two
resistance genes, the scientists expected to find that bacteria
from the two regions were genetically different.
How many different
genes for antibiotic
resistance come to Israel
from the various dust storms, and how prevalent are these
genes?
The reference genome
from QMUL was used by scientists at University of York who discovered
genes that are associated with greater
resistance to ash dieback.
Not only can molecular biologists swap
genes in and out of organisms to increase their virulence or
resistance to antibiotics, they can now assemble entire pathogens wholly
from scratch.
And the shared map implies that
genes for important characteristics, such as disease
resistance, photoperiodism, drought tolerance, storage proteins and the like, can be plucked direct
from one genome and applied in another.
«Invasive weed Kochia's
resistance to well - known herbicide stems
from increase in
gene copies.»
Five decades on
from the appearance of the first MRSA, multiple MRSA lineages have emerged which have acquired different variants of the
resistance gene.»
This analysis, done on separate samples
from the same patient, revealed that many of the affected
genes confer advantages to cancer cells by, for example, enhancing cell migration or
resistance to chemotherapy.
And both bacteria displayed the very same
resistance gene — most likely it had been transferred to them
from bacteria living in the gastrointestinal tract.
It will also allow for easier identification of
genes that contribute to the bacteria's spread
from patient to patient, and more meaningful scientific experiments to understand the bug's
resistance to antibiotics or identify new antimicrobial compounds that target specific
genes necessary for maintaining these persistent infections.
Collected in Denmark — where antibiotics were banned in agriculture
from the 1990s for non-therapeutic use — the soil archives provide an «antibiotic
resistance timeline» that reflects resistant
genes found in the environment and the evolution of the same types of antibiotic
resistance in medicine.
Analysing the samples, the team — involving experts
from Newcastle University, the University of Strathclyde and Aarhus University — were able to measure the relative abundance of specific β - lactam antibiotic resistant
genes, which can confer
resistance to a class of antibiotics that are of considerable medical importance.
As a team of researchers
from four European countries and South Korea report in Science today, a
gene the group dubbed ethA2 is normally inactive in M. tuberculosis, so the bacteria hasn't had a chance to develop
resistance to it.
They found that the phages
from antibiotic - treated mice carried significantly higher numbers of bacterial drug -
resistance genes than they would have carried by chance.
That's because gut phage
from mice treated with one drug carried high levels of
genes that confer
resistance to different drugs, which means that the phage could serve as backup when bacteria must find ways to withstand a variety of antibiotics.