A plasmid is like a bacterial gene delivery truck; it is the primary way antibiotic
resistance genes spread between bacteria.
In both cases,
the resistance gene spread significantly more slowly in the populations under the influence of pesticide.
Not exact matches
Microbes could load these donated
genes together on a single piece of DNA, accelerating the
spread of
resistance even further.
No doctor wants to ignore an opportunity to save a patient from infectious disease, yet much of what is prescribed is probably unnecessary — and all of it feeds the
spread of
resistance genes in hospitals and apparently throughout the environment.
The answer is important because sludge bacteria are much more likely to thrive and
spread their
resistance genes once the sludge is discharged into rivers (in treated wastewater) and onto crop fields (as slurried fertilizer).
At this stage, the bacteriophage infected other Salmonella cells, possibly also
spreading novel virulence or
resistance genes, the authors say.
The researchers found that the
gene conferring drug
resistance has
spread among bacteria in China, where colistin is widely fed to livestock as a prophylactic.
Last year, his group found the hotly sought molecular marker of artemisinin
resistance, the Kelch 13 or K13
gene, enabling researchers to map its extent and
spread in exquisite detail.
Traditional antibiotics lay waste to most bacteria, but some cells inevitably survive, and their mutated
genes — which are the source of
resistance —
spread through the population.
Identifying where
resistance genes come from and how they
spread somewhat compares to finding patient zero in an outbreak, which is not an easy task.
The
gene for colistin
resistance can be easily
spread to other bacteria, making it likely that colistin
resistance will become widespread in the future.»
Researchers have been tracking the
spread of artemisinin - resistant parasites first by looking for signs in patients, and later by using multiple mutations in the parasite's Kelch13, or K13,
gene, as molecular markers for
resistance.
It will also allow for easier identification of
genes that contribute to the bacteria's
spread from patient to patient, and more meaningful scientific experiments to understand the bug's
resistance to antibiotics or identify new antimicrobial compounds that target specific
genes necessary for maintaining these persistent infections.
The
genes encoding NDM - 1 and other antibiotic
resistance factors are usually carried on plasmids — circular strands of DNA separate from the bacterial genome — making it easier for them to
spread through populations.
«New technology could reduce
spread of antibiotic
resistance genes through compost.»
In fields containing refuges of non-modified plants,
resistance genes were less likely to be
spread through the moth population.
«It is incredibly tempting to assume that antibiotics are promoting the
spread of
resistance by increasing the rate at which bacteria share resistant
genes with each other, but our research shows they often aren't.»
«Antibiotics don't promote swapping of
resistance genes: Bacterial
resistance spreads through population dynamics, not an increase in
gene transfers.»
The message seems clear: antibiotics are losing their magic touch after decades of incautious prescription, improper use and the inevitable
spread of bacterial
genes that confer drug
resistance.
The findings thus challenge the generally held perception that wastewater treatment plants are hotbeds for the
spread of antimicrobial
resistance genes.
Both the carbapenem
resistance and the colistin
resistance genes are on separate plasmids, which means in principle they could
spread to other bacteria.»
Resistance to colistin has been observed before, but the mutations in bacteria
genes that were responsible could not
spread outside of the bacteria that developed them and their immediate progeny.
Non-flowering plants could also ensure the containment of
genes for herbicide
resistance (or other traits conferred to the organisms), counteracting the concern that transgenic trees would
spread their lab - produced genetics throughout nearby wild forest.
These
genes exist on plasmids, small segments of DNA that are capable of moving from one bacterium to another, potentially
spreading antibiotic
resistance to other bacterial species.
Still, the apparent benefits of
resistance may not be big enough to help the
gene spread through a population in the wild, where not all the hosts are infected, says co-author Jason Rasgon.
If rats with this degree of
resistance suffer no disadvantages, then the
resistance gene will
spread and coumarin - derived poisons will become increasingly useless.
He agrees with Chénier about the need for more research on the
spread of
resistance genes from farms to the environment.
«If mcr - 1 is present in India then that will be a disaster,» says Ghafur, who fears it will
spread as fast as did
genes for
resistance to another antibiotic of last resort, carbapenem.
Biofilms allow these pathogens to resist disinfectants and environmental stressors, and aid in the
spread of antibiotic
resistance and virulent
genes.
Inspired by natural
gene drives, researchers have spent decades trying to perfect a system that might endow a population of mosquitoes with a malaria
resistance gene, for example, or
spread a lethal
gene that cuts down a local population of invasive insects or rodents.
Only 18 months later, 25 percent of hospital patients in certain areas in China tested positive for bacteria with this
gene:
resistances start
spreading at unprecedented speeds.
Conjugation is the main route for horizontal
gene transfer in bacteria and is responsible for the
spread of antibiotic
resistance.
These
resistance genes can be
spread among different bacterial species by bacteriophage,...
Our results indicate that
S. argenteus has
spread at a relatively rapid pace over the past 2 decades across northeastern Thailand and acquired multiple exotoxin and antibiotic
resistance genes that have been linked previously with livestock - associated
S. aureus Our findings highlight the clinical importance and potential pathogenicity of
S. argenteus as a recently emerging pathogen.
Strong signals of recent selection were observed in insecticide -
resistance genes, with several sweeps
spreading over large geographical distances and between species.
New nightmare bacteria that have the potential to
spread their
resistance genes to germs in hospitals around the...
Researchers confirmed that other gonococci strains were able to take up the ceftriaxone -
resistance gene, showing its potential to
spread in the wild population.