The investigators compared
the resistance genes with currently known resistance genes.
By combining understanding of
resistance genes with knowledge of the pathogen, they hope to develop Desiree and Maris Piper varieties that can completely thwart attacks from late blight.
To find out if their guess was right, Levin, Schrag, and Perrot made some of the drug - resistant bugs susceptible again by replacing
their resistance gene with a gene that conferred sensitivity.
Not exact matches
I won't reveal yet who my favorites are, but I will say that these young scientist - founders came up
with very creative solutions for preventing infections in some common surgeries, tackling
resistance in targeted antibody drugs, improving
gene vectors for cell therapies, helping the vision - impaired «see» faces and better read their environments, imaging hard - to - see spots in the lungs and other organs, improving genetic risk analysis, and expediting the logistical operations of hospitals.
With respect to antibiotic
resistance, this novelty can be induced and we can trace the novelty to particular mutations arising absent
gene transfer; i.e. the
genes which give rise the
resistance were not present prior to the mutation, they are new sequences and not simply the activation of dormant
genes.
By adding these new
genes, genetic engineers hope the plant will express the traits associated
with the
genes, such as
resistance to certain diseases or herbicides.
The advent of rice varieties bearing
genes with resistance to the disease has changed the perception about the disease: the incorporation of host - plant
resistance genes in rice varieties, their adoption and deployment in the world's main rice - producing environments is probably one of the most significant evidences of the role of plant pathology in agricultural development.
In particular, the PTPRF
gene, which is known to suppress intracellular signals that are usually triggered by insulin binding to its receptor on the cell surface, may serve as a biomarker linking insulin
resistance with insufficient milk supply.
Researchers found RGA2
gene activity level in the modified bananas was «strongly correlated»
with TR4
resistance
Specifically, they have found unnaturally high levels of antibiotic
resistance genes in sediments where the river comes into contact
with treated municipal wastewater effluent and farm irrigation runoff as it flows 126 miles from Rocky Mountain National Park through Fort Collins and across Colorado's eastern plain, home to some of the country's most densely packed livestock operations.
A 2003 study of the mouths of healthy kindergartners found that 97 percent harbored bacteria
with genes for
resistance to four out of six tested antibiotics.
These adaptations include the massive and rapid expansion of
gene families that produce venom toxins, providing the snake
with a highly toxic protein mixture required to overcome a variety of different prey and also circumvent any
resistance to venom that may have developed in such prey.
One of the newest banes of U.S. medical centers, a supervirulent and multidrug - resistant strain of Acinetobacter baumannii, likewise appears to have picked up most of its
resistance in
gene swaps
with other species.
The more diverse the
genes of the MHC, the more effective it is at conferring disease
resistance, and in a variety of animals individuals
with diverse MHCs are more likely to be chosen as a sexual partner.
«When you contaminate a site
with resistance genes, those
genes can be transferred into environmental organisms and actually increase the concentration of contamination.»
When the team induced expression of the corresponding
gene in the leaves of two other plant species (one closely related to S. lycopersicum and the other more distantly related), both plants reacted to presence of the C. reflexa peptide
with increased production of ethylene, and exhibited increased
resistance to C. reflexa infestation.
The researchers — James Robl, a developmental biologist and his colleagues at the University of Massachusetts at Amherst, and Steve Stice at Advanced Cell Technology in Worcester, Massachusetts — inserted a marker
gene fused
with a
gene for
resistance to the chemical neomycin into a culture of connective tissue cells called fibroblasts.
Women
with high levels of FGF1 were less likely to respond to platinum - based drugs, but blocking the
gene makes their cells lose their
resistance (British Journal of Cancer, DOI: 10.1038 / bjc.2012.410).
Nor would they be able to receive any
genes from natural bacteria that would endow them
with antibiotic
resistance or the ability to make toxins.
Barnes and colleagues selected 23 genetic markers throughout the
gene and tested whether any of them were associated
with worm
resistance in the residents of Conde.
Genes associated
with tick
resistance were identified in all five breeds.
So even if you start off [
with] say, a resistant type of staph infection, that line of staph organisms not only, will they be more resistant, but they may pass some of the
genes for that
resistance off to completely other unrelated types of bacteria.
New research presented here yesterday at the annual meeting of the American Association for the Advancement of Science (which publishes ScienceNOW) finds that a
gene associated
with increased risk of asthma is also linked to
resistance against a parasitic worm.
The study found several
genes that are associated
with resistance to antibiotics, including new
genes that might point to previously unknown mechanisms of drug
resistance.
There is a very good reason microbes would be armed
with antibiotic
resistance genes, the researchers explain.
As millions of tons of fishmeal are used every year
with much of it sinking uneaten to the ocean floor, Jing Wang and colleagues wanted to see what its impact could be on the mariculture «resistome,» or collection of
resistance genes.
But by investigating the DNA sequence around the
resistance genes, the team figured out how the
resistance genes transfer occurred through a new mechanism named «carry back,» where the pathogen basically has a primitive form of «sex»
with the Actinobacterium and takes up its
resistance genes after it dies.
The object of the experiment is to mutate a
gene in the bacteria, giving it antibiotic
resistance, then prove it by dosing the cultures
with antibiotics.
Bacteria expressing enzyme in one cell (bright green), while genetically identical cells do not, remaining protected from antibiotic onslaught; image courtesy of Yuichi Wakamoto / Neeraj Dhar / John McKinney Some strains of nasty bacterial infections, such as MRSA (methicillin - resistant Staphylococcus aureus), come loaded
with resistance to antibiotics built right into their
genes.
The wild Asian banana Musa acuminata malaccensis — the genome of which was published last year (A. D'Hont Nature 488, 213 — 217; 2012)-- seems to be resistant, and researchers are experimenting
with putting its
resistance genes into the Cavendish.
A faulty
gene that causes insulin
resistance may be a causative factor in nearly half of all families
with obesity, a new study suggests.
The reference genome from QMUL was used by scientists at University of York who discovered
genes that are associated
with greater
resistance to ash dieback.
While the increase in EPSPS
gene copies has created a nonsustainable way of controlling kochia
with glyphosate - only programs, Jugulam said this
resistance was evolved as the result of continuous use of glyphosate and the lack of herbicide diversity in controlling this weed.
«Plants
with one type of glyphosate -
resistance mechanism make multiple copies of the target site for glyphosate, a
gene called EPSPS.
Whatever this compensatory mutation was, it needed to be paired
with the initial
resistance gene.
The researchers also found
genes in these isolates that confer
resistance to numerous other antibiotics, as well as
genes associated
with decreased susceptibility to disinfectants.
«Dangerous bacteria found after sewer spills: Bacteria equipped
with genes that can transfer antibiotic
resistance adds to a sewage spill's public health threat.»
The scientists also found that the extract affects the
gene expression of the bacteria, by repressing a number of
genes linked
with antibiotic
resistance and virulence.
One of them was able to cause full - blown disease symptoms — tan spore - producing lesions on the leaves — on eight soybean lines, including two
with multiple
resistance genes.
To grow a plant
with better salt tolerance or pest
resistance, scientists must first add
genes to the embryo.
«Nevertheless, this
gene will be useful in combination
with other STB
resistance genes, and our study provides tools for rapid lab - based tracing of Stb6 in wheat breeding lines,» says Kanyuka.
«By comparing the two timelines, we saw the appearance of each specific
gene in the soil samples was consistent
with the evolution of similar types of
resistance in medicine.
«When we treat mice
with certain classes of drugs, we see enrichment of
resistance genes to those drug classes,» Modi said.
They also created Cavendish lines
with Ced9, a nematode
gene known to confer
resistance to many kinds of plant - killing fungi.
That's because gut phage from mice treated
with one drug carried high levels of
genes that confer
resistance to different drugs, which means that the phage could serve as backup when bacteria must find ways to withstand a variety of antibiotics.
Biotechnologist James Dale and colleagues at Queensland University of Technology in Brisbane, Australia, cloned a
resistance gene named RGA2 from a type of wild banana that's impervious to TR4 and inserted it into the Cavendish, creating six lines
with varying numbers of RGA2 copies.
Analysis of historic soil archives dating back to 1923 has revealed a clear parallel between the appearance of antibiotic
resistance in medicine and similar antibiotic resistant
genes detected over time in agricultural soils treated
with animal manure.
Ivo Rieu's research group also studies
genes that provide plants
with an increased heat
resistance.
These crops, being embraced by big agriculture in the U.S., carry
genes that imbue them
with resistance to herbicides and lace their tissues
with a bacterial toxin harmless to humans but fatal to pests that may try to feed on them.
To date, all known integrons have been associated
with genes for antibiotic
resistance.