If we understand the special features of insulin
resistance in endothelial cells, we may be able to find more effective treatments against artery damage and cardiovascular disease in people with diabetes.»
Not exact matches
«We're very interested
in following up by finding more direct proof that if you block the recruitment of immune
cells to tumors, you can reverse this phenomenon
in these animals with
endothelial cell insulin
resistance,» Rask - Madsen says.
(3,18; cf. 19,20) Even
in visceral fat, it has recently emerged that the obesity - driven rise
in inflammation and insulin
resistance is associated with an abnormal accumulation of senescent
cells, albeit senescent
endothelial cells rather than adipocytes.
Recent studies have reported that GLP - 1 improves the function of renal
endothelial cells (which regulate blood clotting, immune response and blood vessel activity, among other critical functions, and are impaired by insulin
resistance) and can prevent some renal pathologies
in diabetic rodents.
«Schlemm's canal
endothelial cells are believed to be one of the
resistance sites crossed by the aqueous humor before entering the blood circulation and are likely to play an important role
in the regulation of aqueous humor outflow
resistance.
The new findings build on a 2010 study conducted by Rask - Madsen, which found that insulin
resistance only
in endothelial cells is sufficient to increase susceptibility to atherosclerosis.