Dr Olivo Miotto discusses key discoveries in the ongoing attempts to understand the genetic basis of artemsinin resistance, including the identification of artemisinin resistant P. falciparum founder populations in Cambodia and the
artemisinin resistance marker in the kelch propeller domain.
Similar to other Unyvero Applications, Unyvero UTI allows the rapid detection of pathogens and genetic
resistance markers in a broad range of routinely available patient sample types, such as midstream urine, catheter urine, suprapubic aspiration, and tissue.
They also say they are concerned about the antibiotic
resistance marker gene that the wheat contains, and assert that the researchers «are openly releasing a synthetic version of a compound that... has had no long - term health safety tests whatsoever for human consumption, or for its impacts on non-target species.»
The «slow kill» therapy sometimes prescribed by veterinarians is never appropriate, as it has been demonstrated that using this modality — repeated macrocyclic lactone administration over a period of time — increases the proportion of circulating microfilariae that
possess resistance markers.
In previous posts for our Plasmids 101 series, we examined a number of important plasmid elements — promoters, origins of replication, protein tags, and
antibiotic resistance markers (just to name a few).
Analysing 1612 samples from 15 locations in Southeast Asia and Africa, the researchers were able to identify 20 mutations in the kelch13 gene, a known
artemisinin resistance marker, that appear to work in concert with a set of background mutations in four other genes to support artemisinin resistance.
Antibiotic
resistance markers are