Sentences with phrase «resistant cells»
"Resistant cells" refers to cells that have developed the ability to resist or survive against something that would normally harm or kill them, such as medications or diseases. Full definition
So, during pregnancy the woman's body needs to bump up insulin production to counteract the effect of insulin resistant cells.
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The population of resistant cells stays small because resistance comes with a fitness cost.
The more resistant our cells become to insulin, the more cortisol must be called on to maintain blood sugar levels.
This creates a therapeutic window for chemotherapy to combat even the most drug - resistant cells left behind after surgery or earlier treatment.
Their studies, conducted in cell and animal models of melanoma, demonstrate that the combined therapy could destroy a subset of drug - resistant cells within a tumor.
Do you have any information about how long it takes to restore insulin sensitivity to very resistant cells?
The question we haven't been able to answer is how long does it really take for resistant cells to wake up?
More and more insulin must be released to trigger the same response from insulin resistant cells.
This work is being done in collaboration with Dr. Hasan Korkaya, assistant professor, Biochemistry and Molecular Biology at the Medical College of Georgia, who has developed drug - resistant cell lines, and with breast cancer clinicians.
Fostamatinib's effect on microtubules seems to increase the stabilizing effect of paclitaxel, even in resistant cells, which in turn may prevent cancer cells from proliferating, says Yu Yu, Ph.D., a postdoctoral fellow at the Johns Hopkins University School of Medicine and co-author of the study.
The HIV - resistant cells even migrated to the gut mucosa, an important site for the virus.»
After testing if the cells remained viable, or alive, after printing, the researchers examined how the cells proliferated, how they expressed a specific set of proteins that help tumours spread, and how resistant the cells were to anti-cancer drugs.
Resistant cells among the separate replicates would contain the same labels - i.e. they would always come from the same parent cells that represent the preexisting resistant subpopulation
Targeted cancer treatments are designed to attack molecules produced by mutations, but if the targeted mutation occurs on an evolutionary branch and not the trunk, the treatment will fail as other branches dominate and treatment resistant cells spread.
The research team successfully identified a drug - resistant cell population within hemangiosarcoma tumors that may be an important player in chemotherapy resistance.
Researchers at MedUni Vienna, led by Gerhard Hamilton (Department of Surgery), have now discovered that circulating tumour cells combine, making previously chemo - sensitive cells into chemo - resistant cell complexes.
Instead, we gave it a vehicle to travel in, making it better capable of navigating the terrain inside the inner ear and accessing previously resistant cells,» said Maguire, who is also co-senior author on the study.
But studies from recent years suggest that tumours harbour drug - resistant cells long before they encounter therapy.
Gatenby thinks that he can capitalize on the natural competition between susceptible and resistant cells by managing drug dosage or timing more carefully.
But the persistence of a few straggler antibiotic - resistant cells after treatment with the appropriate antibiotic could be enough to keep the infection alive.
«Because Msi reporter activity can be visualized by live imaging,» said Reya, «these models can be used to track cancer stem cells within the tumor microenviroment, providing a real - time view of cancer growth and metastasis, and serving as a platform to test new drugs that may be better able to eradicate resistant cells.»
A significant advantage of ZFN gene modification, compared to retrovirus based approaches, is that only transient transgene expression is required to permanently engineer an HIV resistant cell.
quote: Jason Jay «its nothing new, the cancer is trying to survive and usually when you do nt kill every cell, the strongest cells are the ones that survive and proliferate even faster» As far as I know this, it means only resistant cells survive and are able to grow.
«The idea is a two - hit strategy,» Peter said, «hit them first with the microRNA and make those drug - resistant cells sensitive again, then hit them again with low levels of conventional chemotherapy.»
Herpesvirus entry mediator on radiation - resistant cell lineages promotes ocular herpes simplex virus 1 pathogenesis in an entry - independent manner.
Moreover, there are yet other cell types — such as visceral adipose tissue macrophages and cytotoxic CD8 + T - cells — in which the age - related supernumerary accumulation of dysfunctional and apoptosis - resistant cells appears to play a highly deleterious role on tissue function, but where the cells are not «senescent» cells in the classical sense of p16Ink4a expression and the senescence - associated secretory profile observed in senescent fibroblasts.
Same - single - cell analysis for the study of drug efflux modulation of multidrug resistant cells using a microfluidic chip.
The screening led to the identification of CDC25A deletions in ATR inhibitor resistant cells.
Working with Carla Guimaraes from Whitehead Member Hidde Ploegh's lab, Carette subjected knockout cells to several bacterial toxins to identify resistant cells and therefore the genes responsible.
Our data suggest that changes in the expression of genes associated with drug resistance and cancer cell «stemness», induced by treatment with MIA - 602, lead to a significant reduction in the efflux capacity of drug resistant cells.
The chemically resistant cells produce fibrous proteins called curli, which can be genetically encoded to take on any number of different properties.
CSC enrichment was achieved by collection of anoikis - resistant cells as we have previously shown this population to be highly enriched for mammosphere and tumor - initiating cells (25).
Some compounds of the dozens of variations the scientists created exhibit potent cytotoxicities against certain cancer cells, including a drug - resistant cell line, Nicolaou said.
In insulin resistant cells, there are lower levels of SIRT1 which could increase insulin resistance.
Evidence shows that fasting may improve: cholesterol levels, how we metabolize glucose, how resistant our cells are to insulin, and even improve our cognitive function.
Resistant cells among the separate replicates would have different labels - i.e. they would stochastically arise from different cells throughout the treatment regimen and were not preexisting.
The scientists then analyzed 25 different ovarian cancer cell lines in the laboratory and discovered that the higher the amount of active SYK in the cell lines, the more resistant those cells were to paclitaxel treatment.
While gold nanospheres, without any accompanying drug, were found to cause significant cell damage, treatment - resistant cell populations did eventually recover several days after the radiotherapy.
«When you go in and take a biopsy or do imaging of the patient's tumor, you can't always count the number of resistant cells or tell which of those cells are going to be resistant,» West said.
Insulin resistant cells are less able to convert glucose into energy, resulting in a peak of blood glucose after eating a meal which goes through the placenta to «feed» the baby.
For a cancer with very high genetic diversity (like AML) however, the unintended effect of treatment is often to select for the most aggressive, resistant cells, clearing away their competitors and furnishing them with all the resources they need to flourish.
But when the researchers treated the resistant cells with the SYK inhibitor fostamatinib, they were able to increase the paclitaxel sensitivity of the cells.
The researchers then found that, while the drug continued to inhibit FGFR activity in the resistant cells, its inhibition of FGFR signaling had no appreciable effect on the cells» survival.
When a patient receives a hefty dose of chemotherapy, however, the resistant cells become much fitter than the susceptible cells.
The resistant cells managed to evolve in a way to bypass the signaling blockade or come up with a new way to maintain proliferation.
By sequencing the genomes of sensitive and resistant cells we showed that some cells were pre-adapted, or primed, while other cells acquired new mutations to gain resistance.»
Let's find something that kills the resistant cells.»