The population of heartworms not exposed to the drugs — heartworms living in wild canids such as wolves, foxes and coyotes, and in untreated domestic dogs — helps to dilute the heartworm gene pool, keeping
the resistant genes from predominating.
Salyers has shown that Bacteroides probably picked up erythromycin -
resistant genes from distantly related species of staphylococcus and streptococcus.
Greenhouse testing has shown 10 to 30 percent reproduction rates on varieties with
resistant genes from PI 88788.
William Powell and Charles Maynard at the State University of New York did an ingenious bit of genetic engineering to introduce a fungus -
resistant gene from wheat, creating a blight - proof American chestnut that can begin to take up its former crucial role in the eastern forest, as soon as the US government okays it as a benign genetically modified organism.
Scientists at SUNY in New York made the trees blight - proof by introducing a fungus -
resistant gene from wheat, and the improved tree is now going through the approval process with government regulators.
Not exact matches
He also suggested that «there is a connection» between Bt cotton, a GM product that includes
genes from Bacillus thuringiensis (Bt) to make it pest -
resistant, and farmers» suicides, referring to thousands of farmers who have committed suicide in the last few years due to indebtedness, mostly in cotton growing regions.
Cavendish Grand Nain were modified with the RGA2
gene, taken
from the TR4 -
resistant wild, south - east Asian banana subspecies, Musa acuminata ssp malaccensis
Unlike other superbugs, a new class of antibiotic -
resistant bacteria are gaining their power
from easily transferable
genes such as NDM - 1
Collins and his colleagues have made other tests that detect
genes from antibiotic -
resistant bacteria.
Is the jump in resistance
genes coming
from a population explosion in the
resistant enteric, or intestinal, bacteria coming into the sewage plant?
Weber is now investigating how fertilizer derived
from human sewage may contribute to the spread of antibiotic -
resistant genes.
Bacteria expressing enzyme in one cell (bright green), while genetically identical cells do not, remaining protected
from antibiotic onslaught; image courtesy of Yuichi Wakamoto / Neeraj Dhar / John McKinney Some strains of nasty bacterial infections, such as MRSA (methicillin -
resistant Staphylococcus aureus), come loaded with resistance to antibiotics built right into their
genes.
From isolated caves to ancient permafrost, antibiotic -
resistant bacteria and
genes for resistance have been showing up in unexpected places.
Rudich says that the study enabled the researchers to identify a «signature» for each source of bacteria based on the prevalence of antibiotic
resistant genes, which revealed whether the
genes were local or imported
from distant deserts.
«With more than 1.7 million people dying globally
from TB each year and the rise of strains that are
resistant to drug treatment, we need a better way to prevent this disease,» said the study's principal investigator Louis Picker, M.D., who is the associate director of the OHSU Vaccine and
Gene Therapy Institute and a professor of pathology, molecular microbiology, and immunology in the OHSU School of Medicine.
As well as identifying the Ebola strains, Collins and his colleagues have made other tests that detect
genes from antibiotic -
resistant bacteria.
Genes from the vancomycin -
resistant bacteria were detected for nearly two weeks following the spill.
When scientists engineered the plants to express the glutathione transferase (DmGSTE6)
gene found in fruit flies, they found that plants expressing the
gene were more
resistant to TNT and were better able to remove it
from contaminated soil than wild - type plants without the
gene.
Deleting a single
gene from mosquitoes can make them highly
resistant to the malaria parasite and thus much less likely to transmit the parasite to humans, according to a new paper
from scientists at Johns Hopkins Bloomberg School of Public Health's Malaria Research Institute.
Collected in Denmark — where antibiotics were banned in agriculture
from the 1990s for non-therapeutic use — the soil archives provide an «antibiotic resistance timeline» that reflects
resistant genes found in the environment and the evolution of the same types of antibiotic resistance in medicine.
Analysing the samples, the team — involving experts
from Newcastle University, the University of Strathclyde and Aarhus University — were able to measure the relative abundance of specific β - lactam antibiotic
resistant genes, which can confer resistance to a class of antibiotics that are of considerable medical importance.
Bacteria can become
resistant to the antibiotic either as the result of a spontaneous mutation or by picking up an appropriate «resistance
gene» (which codes for a protein that confers resistance)
from another bacterium via genetic exchange.
We assume that phages acquire resistance
genes from already
resistant bacteria and then transfer those
genes to other bacteria,» says Hilbert.
He discovered that there is a signal sent
from the chloroplast in response to light, which then activates
gene expression in the nucleus to make the plant
resistant to heat stress.
When they focused on
genes involved in drug resistance, the group found that C. krusei differs
from C. albicans; many of the sites that are often mutated in the target of azole drugs in
resistant C. albicans are not mutated in C. krusei.
«We obtained a total of 36 antibiotic resistance
genes from the antibiotic -
resistant E. coli.»
By adding a single
gene from wheat, researchers have created fungus -
resistant trees that pass their resistance on to their offspring and, hopefully, subsequent generations too (see «American chestnut set for genetically modified revival «-RRB-.
On the flip side, said Tran, PGC1 alpha transgenic mice, which had increased expression of these
genes, were particularly
resistant to various stressors and recovered
from injury much more than quickly than animals with normal regenerative abilities.
In 2009, for example, Sangamo Therapeutics in Richmond, California, began using zinc finger nucleases to modify
genes in immune cells
from HIV - infected people, hoping to make the cells
resistant to the virus.
Bacteria share DNA with other organisms with which they come into contact, so an antibiotic -
resistant gene can transfer
from one type of bacterium to another, and a bacterial cell can become
resistant to numerous antibiotics at once.
New Jersey researchers have identified what is believed to be the first strain of Escherichia coli bacteria
from a patient in the United States that harbored two mobile
genes making it
resistant to both broad spectrum carbapenem antibiotics as well as colistin, an older antibiotic increasingly used as a last resort for multidrug -
resistant infections.
Ethionamide in particular is activated by the enzyme EthA, but some
resistant forms of tuberculosis have developed mutations in the ethA
gene, sparing them
from the toxic effects of the transformed ethionamide.
So for example, if one microbe is
resistant to antibiotics and the other one isn't, if we let them have sex, maybe one of them will pass the resistance
gene on to the other one and we can figure out where it is by seeing how long it takes for that
gene to get
from one microbe to the other.
Although the notion that sharks and rays are more
resistant to cancers needs rigorous scientific confirmation, the results of this new study raise the enticing prospect that the proteins produced by these cancer - related legumain and Bag1
genes have modified functions in sharks, including the possibility of actually protecting the animals
from acquiring cancer.
«We wanted to see if field -
resistant pink bollworm
from India harbored these same changes in the cadherin
gene,» Fabrick said.
Noticing an odd resistance profile, first author Vincenzo Di Pilato, Ph.D., reanalyzed the genome data
from the bacterium, and discovered the new
gene, which is a variant on the colistin -
resistant gene, mcr - 1.
The protocol is supposed to protect countries
from unwittingly importing transgenics that could harm their environment — for example, if a
gene inserted in a crop to make it
resistant to herbicides were to jump into a related weed.
AHR2 is also the same
gene identified in a 2011 Science paper by WHOI biologists and colleagues
from New York University and NOAA on PCB -
resistant tomcod
from the Hudson River.
The researchers hope that what they are learning
from soil bacteria will help identify ways to reduce
gene sharing among infectious bacteria, slowing the spread of drug -
resistant superbugs, said senior author Gautam Dantas, PhD, assistant professor of pathology and immunology.
«We'd anticipate far fewer ecological consequences
from gene - driving one of these naturally occurring proteins into a population of snails, because they'd remain natural in pretty much every other way — just instead of being more susceptible to Schistosoma, they'd be more
resistant.»
Expression of BAC clones containing the Naip5
gene from resistant strains (C57BL / 6J and 129X1 / SvJ) in A / J mice rendered transgenic mice
resistant to infection (J: 81887, J: 129300).
He received his Ph.D. in pharmacology
from Stanford University, where he studied
gene amplification as a mechanism by which cells become
resistant to anticancer agents.
Working with Carla Guimaraes
from Whitehead Member Hidde Ploegh's lab, Carette subjected knockout cells to several bacterial toxins to identify
resistant cells and therefore the
genes responsible.
At a 97 percent rate of inheritance, one lone mosquito carrying an edited
gene that prevents it
from spreading malaria could make an entire population of mosquitoes
resistant to the disease in less than a year.
Several ongoing projects include the identification of newly discovered
gene rearrangements in rare and refractory (unresponsive or
resistant to therapy) tumors
from patients evaluated at the Rutgers Cancer Institute of New Jersey.
Objectives: To investigate the context of the ribosomal RNA methyltransferase
gene armA in carbapenem -
resistant global clone 2 (GC2) Acinetobacter baumannii isolates
from Singapore.
No significant differences were seen between the normoxic and hypoxic anoikis -
resistant populations collected
from MCF7 cells and a single significant
gene change (PIP) was seen in T47D (Table 1) suggesting that the CSC - enriched population remains virtually unchanged following hypoxic culture and the increase in MFC, HFC, and tumor initiating cells is, therefore, due to expansion of the population, perhaps by increased symmetric self - renewal of the CSC or de-differentiation of early progenitor cells, rather than simply the acquisition of anoikis resistance in non-CSC.
To investigate how some bedbugs were defending themselves, scientists compared the
genes of 20 pyrethroid -
resistant populations of the insects
from around the country against a susceptible colony
from Los Angeles, California.
Researchers have created drought
resistant transgenic rice using a
gene from a small Eurasian flowering plant....
Using techniques not unlike DNA fingerprinting, the scientists were able to detect the presence of antibiotic -
resistant genes in soil samples gathered
from all across the U.K.