Sentences with phrase «resistant tumor models»

In a variety of tumor mouse models, including antibody - resistant tumor models, the antibody - IFN therapy was more effective than antibody therapy alone.

Not exact matches

Again, using mouse models of glioblastoma — this time created from brain tumor cells that were resistant to the herpes virus — the therapy led to increased animal survival.

«We hope that our mouse model, which allows us to combine drug testing and genetic analysis, will provide a deeper understanding of why tumors are sensitive or resistant to drugs,» states Ian Frew.

The mice are particularly good models of estrogen receptor - positive tumors (so named because they are fueled by estrogen) that have become resistant to the drugs used to treat them.

These inhibitors effectively targeted and blocked Msi expressing cells, resulting in halted tumor growth in animal models as well as in patient - derived cancer cells, which harbor more complex mutations and are uniformly drug - resistant.

In mouse models of cancer, targeted therapeutic inhibition of translation disrupts this survival response, dramatically slowing tumor growth and potentially rendering drug - resistant tumors vulnerable to other therapies.

Here, we show that ICB increased tumor vessel perfusion in treatment - sensitive EO771 and MMTV - PyVT breast tumor as well as CT26 and MCA38 colon tumor models, but not in treatment - resistant MCaP0008 and 4T1 breast tumor models.