Then, they confirmed the importance of ERBB4 via immunohistochemistry analysis of Lapatinib -
resistant tumors in mice.
Not exact matches
Shih, Wang and their colleagues tested fostamatinib's power to reduce
tumor size
in mice implanted with human ovarian cancer cells that were
resistant to paclitaxel.
In a variety of
tumor mouse models, including antibody -
resistant tumor models, the antibody - IFN therapy was more effective than antibody therapy alone.
In mouse models of cancer, targeted therapeutic inhibition of translation disrupts this survival response, dramatically slowing
tumor growth and potentially rendering drug -
resistant tumors vulnerable to other therapies.
The expression of a
tumor - suppressing protein called TGF beta is more pronounced
in the mammary gland of
mice that are
resistant to cancer (right column) than
in the mammary gland of
mice that are susceptible to cancer (left column).
Publication: «
Mice Lacking a Myc Enhancer Element that Includes Human SNP rs6983267 Are
Resistant to Intestinal
Tumors», Sur, I., Hallikas, O., Vähärautio, A., Yan, J., Turunen, M., Enge, M., Taipale, M., Karhu, A., Aaltonen, L. A., and Taipale, J., Science,
in press, online 1 November 2012.