Sentences with phrase «resolution structures»

Therefore, the system is faster, more accurate and gives higher resolution structures from less virus material.

What has made it possible to get high - resolution structures without crystals is single - particle analysis.

«This is the first atomic resolution structure of this protein from an electrically conductive bacterial species, and it sets the foundation for understanding how these nanowires work,» said structural biologist Patrick Reardon of the Department of Energy's Pacific Northwest National Laboratory.

«For developing cryo - electron microscopy for the high - resolution structure determination of biomolecules in solution,» the Royal Swedish Academy of Sciences awarded the Chemistry Prize to Jacques Dubochet of the University of Lausanne in Switzerland, Joachim Frank of Columbia University in New York City, and Richard Henderson of the MRC Laboratory of Molecular Biology in Cambridge, England.

The atomic resolution structure of hAgo2 solved previously, revealed the active site, a region of the enzyme that is key to its slicing activity.

We present the 3.8 angstrom resolution structure of mature Zika virus, determined by cryo — electron microscopy (cryo - EM).

The Lord Chief Justice and the Master of the Rolls commissioned Lord Justice Briggs to review the civil dispute resolution structure in England and Wales in order to increase access to justice.

At Ali - Curung, dispute resolution structures have been developed that include different roles for Elders from each language group and the Traditional Owners in order to address conflicts that have arisen as a result of relocation.

Five years ago, using a lower - resolution form of electron microscopy in which the protein is visualized in the presence of negative stain, Whelan's team was able to detect at low resolution a structure that looked like a doughnut with three globular domains.

Scientists are providing the clearest view yet of an intact bacterial microcompartment, revealing at atomic - level resolution the structure and assembly of the organelle's protein shell.

a program package for modeling of atomic resolution structures into low - resolution density maps.

This composite image of the protein β - galactosidase shows how cryo - EM has progressed over the years, from the indistinct blobs once obtained with the technique (left) to the nearly 2 - Å - resolution structures possible today (right).

The structure they determined represented one of the highest resolution structures solved by EM at that time.

Shotgun crystallization strategy for structural genomics II: crystallization conditions that produce high resolution structures for T. maritima proteins.

This corresponds to one of the highest resolution structure published so far for any AMPK isoform.

Cypress Professionals believe that transparent, interest - based negotiation conducted in good faith is the ideal conflict resolution structure.

The Nobel Prize in Chemistry goes to Jacques Dubochet, Joachim Frank and Richard Henderson for developing cryo - electron microscopy for the high - resolution structure determination of biomolecules in solution.

We determined the x-ray structure of the human BK Ca2 + gating apparatus at a resolution of 3.0 angstroms and deduced its tetrameric assembly by solving a 6 angstrom resolution structure of a Na + - activated homolog.

«With this high - resolution structure in hand, we anticipate the discovery of compounds that interact with DRD2 in specific ways important for greater therapeutic actions and fewer side - effects,» Roth said.

To continue this work, he moved to the Walz lab as a post-doctoral fellow, where he completed the first atomic resolution structure of a mammalian membrane protein, aquaporin - 0, using electron microscopy.

Over the years, gradual progress in computational power and microscope quality has yielded higher and higher resolution structures.

Analysis of adrenergic receptor ligand - binding mutants within the context of the reported high - resolution structure of β2AR - T4L provides insights into inverse - agonist binding and the structural changes required to accommodate catecholamine agonists.

Then, the group at the MRC in Cambridge used a revolutionary new technique called Single Particle Cryo - Electron Microscopy to generate a three - dimensional, high - resolution structure of a protein, based on thousands composite images.

The 2017 Nobel Prize in Chemistry was awarded jointly to Jacques Dubochet, Joachim Frank and Richard Henderson for developing cryo - electron microscopy that can determine high - resolution structures of biomolecules in solution.

To learn more about this potential building material, the scientists set out to learn its atom - resolution structure.

Thanks to cryo - electron microscopy, «we have been able to visualise, for the first time, the high - resolution structure of the human R2TP system,» states Llorca.

A team from the Spanish National Cancer Research Centre (CNIO) has determined for the first time the high - resolution structure of a complex (R2TP) involved in key processes for cell survival and in diseases such as cancer.

What's more, they discovered it by combining computer simulations with x-ray scattering and imaging methods to determine, for the first time, the atomic - resolution structure of peptoid nanosheets.

«Newly discovered «design rule» brings nature - inspired nanostructures one step closer: First atomic - resolution structure of a peptoid nanosheet.»

«For the first time we have a room - temperature, high - resolution structure of one of the most difficult - to - study but medically important families of membrane proteins,» said Vadim Cherezov, a structural biologist at The Scripps Research Institute (TSRI) who led the research.

Now, for the first time, scientists in Göttingen have solved the high - resolution structure of the molecular transporter TSPO, which introduces cholesterol into mitochondria.

Sirohi et al. present a near - atomic - resolution structure of mature Zika virus determined by cryo - electron microscopy.

The high - resolution structure of the Zika virus showed that the overall virus architecture is similar to other flaviviruses such as the West Nile and dengue viruses.

A high - resolution structure of a specific transporter shows that gaseous ammonia, not charged protonated ammonium, moves across cellular membranes.

At the beginning of the study, the team struggled to produce a crystal form — needed to obtain data to recreate the high - resolution structure — of the receptor bound with AM6538, a stabilizing a molecule that blocks the receptor's action.

The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Chemistry 2017 to: Jacques Dubochet, University of Lausanne, Switzerland; Joachim Frank, Columbia University, New York, USA; and Richard Henderson, MRC Laboratory of Molecular Biology, Cambridge, UK, «for developing cryo - electron microscopy for the high - resolution structure determination of biomolecules in solution.»

Even though crystallography has been successful at determining many high - resolution structures, it is challenging to use this technique to study structures which are not susceptible to crystallization or structural changes that do not naturally occur within a crystal.

First author Vignesh Kasinath said, «It took three years of work to obtain this high - resolution structure of all the parts, or subunits, that make up a functional PRC2, as well as visualize how additional protein subunits, called cofactors, may help regulate its activity.

«Three - dimensional structural information derived from the data obtained at the ESRF was essential for the interpretation of the work, as it led to a high - resolution structure of the new active site and provided conclusive evidence of the role of protein re-organisation in the emergence of the new function» explains Jose A. Gavira, corresponding author, from the University of Granada.

For the study, the researchers used a technique called protein X-ray crystallography to determine the atomic - resolution structure of a part of the 3 - subunit called the «immunoglobulin domain».

An atomic - resolution structure of a late - stage nitrogenase intermediate reveals nitrogen bound to iron in the active site.

The high - resolution structures of SOSIP.664 trimers allow improvements to be rationally designed.

High - resolution structures of the BG505 trimers reinforce this perspective.

By comparing high - resolution structures of two complexes — one containing both a DUB and a pseudo-DUB, and two copies of an inactive DUB by itself — the team determined that KIAA0157 alters the shape of the BRCC36 active site, by swinging an amino acid into position to make the complex able to catalyze chemical reactions.

Axel Brunger (Yale University) and Jahn confirmed and extended these ideas when they reported the high - resolution structure of VAMP / synaptobrevin, syntaxin, and SNAP - 25 in 1998.

DRD2 has undergone extensive study for 30 years, but until now researchers lacked a high - resolution structure of DRD2 attached to a compound.

2017 - Jacques Dubochet receives the Nobel Prize in Chemistry, for his work at EMBL developing cryo - electron microscopy for the high - resolution structure determination of biomolecules in solution.

Within just the past three years, improvements in electron detector technology have yielded an explosion of high - resolution structures.

The high resolution structures are the starting point for the design of lead compounds that are endowed with high specificity, and can undergo further development for the design of highly specific, personalized drugs.

So while bagging high - resolution structures is exciting, Ohi says, their main focus is answering important biological questions.