Sentences with phrase «response against cancer»

She is registred to the National Order of Biologists in the province of Palermo; collaboration in research project from 2012 to 2015 at the Department of Biopathology and Biotechnology, University of Palermo, focusing the study on the identification of molecules capable to modulate intracellular metabolic pathways for the prevention and treatment of infectious, tumor and degenerative disease, in collaboration with Prof. Angela Santoni, University of Rome; collaboration in research project in 2011 at the hospital «Villa Sofia Cervello» of Palermo to study methods can cure the genetic defect that causes thalassemia through genetic engineering; she studies different mechanisms of the differentiation and the activation of human gammadelta T cells as effector cells of the immune response against cancer and infectious diseases; she investigates about the identification and development of biomarkers of resistance and susceptibility to Mycobacterium tuberculosis infection; Valentina Orlando has published 13 papers in peer reviewed journals and 3 comunications at national and international congress.

In different contexts, viruses appear capable of attacking tumors in a number of different ways — by directly infecting them, by releasing tumor proteins that trigger a broad immune response against the cancer, and by damaging the blood supply tumors need to survive.

A recently published paper showed that mice with colon cancer can be «vaccinated» with human embryonic stem cells and have a significant immune response against the cancer (Li et al., 2009).

While much recent research has not been published in this area, there is actually a long history of studies that show: (1) there is a significant number of antigens shared between tumors and embryonic tissues (called «oncofetal antigens») and, consequently, antibodies made against tumors can also recognize embryonic tissues, and vice versa; (2) pregnancy confers some immunity against cancer (accompanied by antibody production against oncofetal antigens), not only against its occurrence but also against its growth; (3) similar to pregnancy, an immune response against cancer can be generated by vaccinating animals with embryonic tissues.

Dr. Khleif's research interest is in identifying new and improved strategies to enhance specific immune response against cancer for preventive and therapeutic intent.

Cancer vaccines, engineered to continue to train T cells to mount a strong immune response against your cancer, also haven't been very effective at mounting a strong fight, says He, and likely one weak point is the lack of strong receptors.

Obesity is associated with increased inflammation, which could improve the effectiveness of checkpoint blockade drugs that unleash an immune response against cancer.

ONLY half of women diagnosed with ovarian cancer live for five or more further years, but a «vaccine» that provokes an immune response against cancer might change that.

«We're able to shuttle millions of cells through this device, generating a very potent immune response against the cancer cells,» Mooney says.

For patients, down the road Dr. Ohashi envisions a new era of combined therapies to simultaneously target and kill these suppressive cells while augmenting the immune response against cancer.

Her current work continues to focus on characterizing the mechanisms that enable immune responses against cancer.

Not exact matches

It also boosts the body's immune response against infections and cancer cells and plays an important role in thyroid function and fertility.

And using cells from someone other than the cancer patient being treated might trigger an immune response against the foreign cells.

On its own, this immune response had no immediate effect in the fight against the utilized breast tumors, but in combination with the ADC it proved itself effective in attacking cancer cells in mice, resulting in the complete cure of the majority of mice receiving the combination therapy.

C. novyi is really a two - pronged weapon against cancer: It germinates in tumors and releases cancer - killing enzymes, and it may also trigger an immune response similar to Coley's Toxin.

Mice raised in a challenging environment had more robust immune responses and hormonal changes, factors that may help protect against cancer

«Personalized tumor vaccine shows promise in pilot trial: Vaccine against patients» own tumors triggers a broad response, and induced five - year remission in one patient with advanced ovarian cancer.»

A recent study published in Cell revealed that, while the related parasite Tritrichomonas musculis makes the intestine susceptible to both colitis and colorectal cancer, it induces an immune response that protects mice against Salmonella infection.

«Dendritic cells are essential for prompting the immune response against malignant cells and for driving the clinical success of cancer immunotherapy, but their function is often defective in cancer patients,» said Dmitry I. Gabrilovich, M.D., Ph.D., Christopher M. Davis Professor and program leader of the Immunology, Microenvironment & Metastasis Program at Wistar.

Spontaneous immune responses were assessed by measuring serum antibodies against ovarian cancer - associated antigens, such as NY - ESO - 1, that are not expressed in normal body tissues but are expressed in cancers.

«We used to think it was too dangerous to use viruses that cause a raging infection,» NIH's David Bodine says, «but we've now realized that this incredible immune response can be turned very specifically against cancer.

Building on these successes, gene therapy may soon be used to correct hereditary genetic diseases like cystic fibrosis, hemophilia, and Tay - Sachs and to activate the immune response against a wide variety of infectious diseases and cancers.

Checkpoint inhibitors already produce unprecedented rates of long - term remission for a handful of hard - to - treat cancers, but their potential is even greater: Because such drugs modify the body's response to cancer, rather than the cancer itself, they could theoretically be effective against almost any kind of malignancy.

«With immunotherapies, there were better outcomes for deeper responses, but it didn't break down the same way as with targeted treatment against ALK - positive cancer,» Doebele says.

Principal Investigator John Morris, MD, clinical co-leader of the Molecular Therapeutics and Diagnosis Program for the CCC, co-leader of the UC Cancer Institute's Comprehensive Lung Cancer Program, professor in the division of hematology oncology at the UC College of Medicine and UC Health medical oncologist, says a number of antitumor vaccines have shown promise for causing immune responses against tumor antigens to improve patient outcomes.

Now, scientists have modified Salmonella bacteria to trigger a particularly powerful immune response against human cancer cells implanted in mice, shrinking the tumors and — for the first time — preventing them from metastasizing.

When delivered to cells in a dish, IL - 2 sticks around for a long time, amplifying the response of natural killer cells against cancer cells.

Less p53 decreases the DNA damage response in patients with Li - Fraumeni Syndrome, and Schiffman's team wondered if more p53 could protect against cancer in elephants by heightening the response to damage.

Several of the current chemotherapies against cancer activate MUS81 and may therefore trigger a stronger immune response.

They used the gene - editing CRISPR / Cas9 technique to sift the genomes of melanoma cells for changes that made tumors resistant to being killed by immune T cells, which are the main actors in the immune system response against infections and cancer cells.

In 2008, he joined the group of Caetano Reis e Sousa at the Cancer Research UK (CRUK) London Research Institute and later joined the Francis Crick Institute, where he was awarded Marie Curie and EMBO long - term postdoctoral fellowships to investigate innate immune receptors and signaling pathways that trigger dendritic cell activation and drive T - cell responses against viruses or tumors.

He adds, «This study was actually a pilot project for a much larger effort within the Center for Molecular Therapeutics to map responses against drug combinations across hundreds of cancer cell lines, not just melanoma, and look for novel combinations that will benefit subsets of patients regardless of the particular type of tumor they have.

Immunity is key to long - term responses Knowing that the immune system is capable of recognizing distinctive features of cancer cells and launching a T cell attack against those tumor antigens, and that checkpoint blockade removes a roadblock to that attack, it's logical that these drugs should work against many tumor types.

«If you immunize people with an antigen that induces an immune response against schistosomiasis, there will likely be benefits not only in controlling the immediate infection but also a means to avoid bladder cancer.»

Other reported effects of PPAM included inhibition of autophagy which is an important survival mechanism that protects cancer cells against stress, impairment of the unfolded protein response (UPR) induced by glucose starvation and decrease of the activity of STAT3 [72, 73].

Affigen's focus is on driving powerful immune responses against molecules unique to cancer, while minimizing the risk of damage to healthy tissues.

Jäger E, Stockert E, Zidianakis Z, Chen YT, Karbach J, Jäger D, Arand M, Ritter G, Old LJ, Knuth A. Humoral immune responses of cancer patients against «Cancer - Testis» antigen NY - ESO - 1: correlation with clinical ecancer patients against «Cancer - Testis» antigen NY - ESO - 1: correlation with clinical eCancer - Testis» antigen NY - ESO - 1: correlation with clinical events.

Immuno - oncology, as the name implies, recruits the immune system into the battle against cancer, either by boosting its existing but latent anti-tumor responses or honing its recognition of malignant cells.

Cancer vaccines are designed to stimulate an immune response against tumor - specific or tumor - associated antigens, encouraging the immune system to attack cancer cells bearing these antCancer vaccines are designed to stimulate an immune response against tumor - specific or tumor - associated antigens, encouraging the immune system to attack cancer cells bearing these antcancer cells bearing these antigens.

Numerous studies have demonstrated activity of these agents against a wide variety of cancers, especially cancer stem cell - like subpopulations, by a host of different mechanisms which comprise inhibition of signaling pathways, of mitochondrial respiration, as well as of cellular stress responses and others.

This includes utilizing a modified chimpanzee virus as a vaccine carrier to induce an immune response against HIV, and a new therapeutic vaccine against human papillomavirus (HPV), a leading cause of cervical cancer.

«I wanted as much to initiate a cancer immune response as I wanted to initiate one against infection.»

Therapeutic vaccines are designed to elicit an immune response against tumor - specific or tumor - associated antigens, encouraging the immune system to attack cancer cells bearing these antigens.

Therapeutic cancer vaccines are designed to elicit an immune response against tumor - specific or tumor - associated antigens, encouraging the immune system to attack cancer cells bearing these antigens.

Dr. Alessandro Sette has devoted more than 30 years of study towards understanding the immune response, measuring immune activity, and developing disease intervention strategies against cancer, autoimmunity, allergy, and infectious diseases.

Cancer vaccines are designed to elicit an immune response against tumor - specific or tumor - associated antigens.

Two clinical trials that used antibodies to block PD - 1 and PD - L1, a related molecule that binds to PD - 1, resulted in significant and long lasting responses against melanoma skin cancer, renal cell (kidney) cancer, and lung cancer.

They can attack cancer cells directly, or they can be used to trigger an immune response against the tumor (so - called cancer immunotherapy).

«We have created a potentially much less expensive approach to making a therapeutic cancer vaccine that, while targeting a single tumor antigen, generates an immune response against multiple antigens.

It is Dr. Chou's hope that, by treating colon cancer stem cells with DAC and then exposing them to immune cells that have been primed to recognize NY - ESO - 1, he can generate a targeted and durable immune response against these cells without harming healthy cells.