Sentences with phrase «response gene network»

In light of the widespread role of oxidative stress in the pathology of diverse human diseases and the ability of the Nrf2 - dependent antioxidant response gene network to protect against oxidative stress, considerable effort has been directed towards discovering compounds that can increase the activity of Nrf2.

Not exact matches

The researchers suspected those hyperactive genes might be behind the resistance — playing off each other to create a smaller network within the larger tuberculosis response network.

With the completion of the first phase of the Human Genome Project in 2000, and the advent of sequencing technologies that can detect gene variations such as single nucleotide polymorphisms (SNPs), for the first time scientists have the tools in hand to find the key immune genes and genetic networks that play roles in vaccine response.

The study, «Transcriptome Sequencing Implicates Dorsal Striatum - Specific Gene Network, Immune Response and Energy Metabolism Pathways in Bipolar Disorder,» [http://www.nature.com/mp/journal/vaop/ncurrent/full/mp201694a.html] was supported by funding from the State of Florida.

«We realized that studying the lithium response could be used as a «molecular can - opener» to unravel the molecular pathway of this complex disorder, that turns out not to be caused by a defect in a gene, but rather by the posttranslational regulation (phosphorylation) of the product of a gene — in this case, CRMP2, an intracellular protein that regulates neural networks,» added Snyder.

Thus, interactome hubs such as NR1 may exhibit low levels of change in individual gene expression following hypoxia, but, based on analysis of interaction networks, are likely to play an important role in regulating the biologic response.

A thematic examination of the coexpression modules enriched for relaxation effect genes showed a suppression of correlated networks regulating stress responses, inflammation and wound healing.

Integrated systems biology approaches can identify gene regulatory networks, such as immune, stress and other regulatory responses, and link them with physiologic states.6 This bioinformatics approach provides an unbiased view of the immune system profile, and can be linked to changes in environmental conditions.7 These network approaches, while often applied to identifying disease profiles, can be used to identify salutary states as well, such as that which might result from intensive meditation.

Her research interests are focused on the reconstruction of cell response networks from integrated gene and protein expression data to enable predictive mechanistic modeling of disease and toxicity pathways.

Her team combed extensively through the literature and identified «the placebome,» a network of genes that influence the placebo response.