Sentences with phrase «response leads the cells»

In time the eye's wound - healing response leads the cells to spread across the underside of the artificial lens.

Not exact matches

The Force spokesman added:» The Inspector General of Police, Ibrahim Idris, deployed Police Special Intervention Force, comprising five units of the Police Mobile Force, five Cells of Counter Terrorism Unit, Conventional Policemen, Special Anti - Robbery Squad, Intelligence Response Team, Technical Intelligence Unit, SIB, detachment of EOD and Police K9 (Sniffer Dogs Section), with their Headquarters in Ile - Ife, led by the Commissioner of Police in charge of PMF, Force Headquarters, Abuja.

As the immune cells in the recipient recognize transplanted cells as foreign, they mount an inflammatory response that can lead to the body rejecting the transplant.

Without the regulatory influence of PD - 1, the over activated and over stimulated T cells result in disruption of a crucial balance between different T cell types that leads to an overall greatly reduced immune response.

Led by researchers at the Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James), the retrospective study suggested that a pattern of molecules called microRNA (miRNA) in tumor cells might predict patients» response to radiation therapy.

George Klinman, an FDA immunologist and lead author of the report, speculates that dangling the protein in front of the immune system in an unusual setting — on a muscle cell — might be what triggers the inappropriate response.

Activation of these receptors led to a «massive mobilisation» of myeloid - derived suppressor cells (MDSCs), which play a crucial role in lowering the immune system response back down to normal levels (European Journal of Immunology, DOI: 10.1002 / eji.201040667).

«So, we not only found a new mechanism for cGVHD development by demonstrating that this miR -17-92 is heavily involved in the T - and B - cell responses that lead to cGVHD, but we also found that blocking miR - 17 substantially reduced cGVHD symptoms in mice.

In GVHD, donor cells trigger an immune response that attacks normal tissues, leading to a chain reaction of cellular and molecular responses that increase morbidity and mortality in these patients.

In this study, the researchers noted that conventional approaches to modifying organisms to consume novel nutrients constitutively (i.e. with no «off switch») can lead to inefficiencies when the nutrient metabolic pathways are not linked to downstream pathways for stress - responses, cell growth and other functions important for the health of the organism.

«We've shown that a specific type of these cells, known as follicular helper T (Tfh) cells are not only necessary, but are a limiting factor that differentiates between an average and a potent antibody response to HIV,» says Crotty, a scientific collaborator with the Center for HIV / AIDS Vaccine Immunology & Immunogen Discovery (CHAVI - ID), a major research consortium led by The Scripps Research Institute.

APOE4 provoked inflammation responses in the normally friendly astrocytes and microglia, leading those cells to kill neurons, the researchers found.

«We also found that reduced cohesin led to changes in the expression of genes involved in nerve cell development and the response to an immune signaling protein,» corresponding author Toshihide Yamashita says.

«Our study suggests that although you need to have some level of IgE to trigger a food allergy response, you also have to produce MMC9 cells to get a severe response and anaphylaxis,» says Yui - Hsi Wang, PhD, lead investigator and a researcher in the Division of Allergy and Immunology at Cincinnati Children's.

A certain cytokine, or small protein that helps cells communicate during immune responses, can control whether immune cells promote or suppress inflammatory bowel disease, a finding that could lead to new treatments, according to a study led by Georgia State University.

The Dartmouth team, led by Mary Jo Turk, Ph.D., established the crucial role of resident memory T cells in the skin in eliciting a strong protective response against melanoma.

In asthma this aberrant immune response leads to immune cells infiltrating the lungs, where they cause inflammation that affects lung function and leads to difficulties in breathing.

Even selective, highly focused treatments that harm cancer cells almost exclusively lead to a similar response.

«Understanding the molecular mechanism that leads to CD8 T cell exhaustion brings us a step closer to developing strategies to induce optimal T cell responses that can successfully clear infections and kill tumor cells,» explains postdoctoral researcher and co-lead author Renata M. Pereira, Ph.D. «Conversely, it may allow us to interfere with autoimmune responses that paradoxically depend on the same protein.»

For most available T cell immunotherapies, T cells (which play a central role in defending the body against illness) are engineered to recognize and eliminate tumors, but their activity is not specifically controlled, leading to toxicity and unwanted side effects in patients as a result of inflammation or in some cases suboptimal response to treatment.

The results, published in tomorrow's issue of Cell, might also lead to new measures for preventing gray hair by modulating the DNA damage response.

This discovery lays the groundwork for a better understanding of the role progenitor cells can play in immune system response and could lead to the development of more effective therapies for a wide range of diseases.

Subsequent exposure of uninfected dendritic cells to these extracellular TB antigens led to a strong T cell response, even in the absence of the TB bacterium and infection of dendritic cells.

«Repetitive heading could set off a cascade of responses that leads to degeneration of brain cells over time,» noted Dr. Lipton.

But for patients with psoriasis, these cells may be the source of the misguided immune response that leads to red, inflamed patches on the skin.

A team led by principal investigator Donald M. O'Rourke, MD, an associate professor of Neurosurgery at Penn, and Marcela Maus, MD, PhD, showed that CART - EGFRvIII cells had an acceptable safety profile, crossed the blood - brain barrier, infiltrated the tumor, and prompted an immune response, resulting in reduction of the EGFRvIII tumor antigen in GBM cells.

Professor Spano said: «In this patient we observed, as expected, both a re-activation of HIV and an increase in CD8 T cell responses against HIV, which resulted in the drastic decrease in the HIV reservoir, thus leading to a sustained reduction of the HIV reservoirs.

Lead author Nigel D'Souza, then a postdoctoral researcher at Lamont, discovered the phytoplankton response to oil seeps while on a ship in the Gulf of Mexico monitoring chlorophyll fluorescence — energy that is emitted as light by compounds inside phytoplankton cells used for photosynthesis.

New findings published in the journal Nature Chemical Biology by UNC School of Medicine scientists show that MRGRPX2, a receptor protein on the surface of mast cells, can trigger the immune system response that leads to itching associated with some opioids.

The team, led by Stephen Liberles, Harvard Medical School associate professor of cell biology, has effectively deconstructed the vagus nerve, a key connection between body and brain that is important because it controls not only breathing but also heart rate, feeding behavior and responses to illness.

«New research helps explain why a deadly blood cancer often affects children with malaria: Immune responses to malaria - infected red blood cells appear to sometimes lead to cancer - promoting changes.»

While the observed differences of the individual steps were mostly modest, mathematical modeling suggested that even small delays in the trafficking of these immune cells will lead to reduced initiation of a WNV - specific antibody - response during the early stages after infection.

A study led by researchers at the University of Illinois at Chicago points blame at a regulatory molecule in cells called TRIP - Br2 that is produced in response to overeating's stress on the machinery cells use to produce proteins.

«There are two types of T cells — CD8 and CD4 — which battle invading pathogens,» explains lead author Pablo Penaloza - MacMaster, PhD, a postdoctoral fellow in the Barouch laboratory and Instructor of Medicine at HMS «The CD8 T cells take the lead in eliminating virally infected cells while the CD4 «helper» T cells function indirectly, serving to bolster the responses of both CD8 T cells and antibody - producing B cells.»

However, an overactive stimulation of mTOR in response to nutrients and growth factors — metabolic processes that are crucial in tumor biology — leads to an increase in cell growth and proliferation.

The force of that blood flow helps keep the cells that line the blood vessels, called endothelial cells, healthy; when blood flow is disrupted, such as during surgical procedures or a stroke, the vessels start to leak, which can cause a host of inflammatory responses that lead to cell damage and disease.

Without Caveolin - 1, the binding of viruses or bacteria to the B cell results in a reduced activation signal, which leads to a weakened immune response.

The fetal cells» ability to keep the immune response in check is quite potent, he says, and harnessing that ability in adults could lead to new ways to treat autoimmune diseases, in which the body improperly attacks its own cells.

In the new paper, researchers led by Dr. Torres showed that LPA keeps T cells inactivated even after they have «seen» a target, or antigen, on a cancer cell that would normally trigger an immune response.

The 2012 Nobel Prize in Chemistry was awarded jointly to Robert J. Lefkowitz and Brian Kobilka for studies of G - protein - coupled receptors, which are the portals by which information about the environment reaches the interior of cells and leads to their responses.

A study led by scientists from Harvard Medical School reveals «hidden» variability in how tumor cells are affected by anticancer drugs, offering new insights on why patients with the same form of cancer can have different responses to a drug.

On a cellular level, FnEDA triggered an immune response in skin cells, leading to fibrosis.

We also appreciate the curiosity of students in Keene State College's Stem Cells and Regeneration class that led to the discovery of the light - induced depigmentation response.

Our results suggest that the lipid - activated transcription factor PPARγ orchestrates a transcriptional response leading to the development of a dendritic cell subtype with increased internalizing capacity, efficient lipid presentation, and augmented potential to activate iNKT cells.

The uncontrolled response of white blood cells in the intestine leads to chronic inflammation.

In this context, we have studied the role of ERK7 in Drosophila S2 cells in response to serum starvation, and have shown that amino - acid starvation leads to the formation of a of novel membrane-less stress assembly, the Sec bodies, as well as stress granules.

Using transplantable tumor models expressing antigen in an inducible manner or spontaneous tumor models expressing nominal antigens, we try to decipher whether the tumor is ignored or leads to deletion, anergy or class switch of the specific immune response or generate suppressor T cells.

These are chronic immune disorders in which an uncontrolled response of mucosal immune cells leads to severe inflammation in the intestine.

The late - boost study, led by scientists from AFRIMS and the Thai Ministry of Health, found that vaccine boosts containing AIDSVAX B / E generated increased, but short - lived, humoral and CD4 + T - cell responses that did not rise further after subsequent boosting.

«We show that Sirt4 is responsible for regulating both lifespan and metabolism in an organism, and specifically that it coordinates the metabolic response to fasting,» said lead author Jason Wood, a researcher in Brown University's Department of Molecular Biology, Cell Biology and Biochemistry.