The researchers made use of 2 genetically unique mouse strains that show distinctive
behavioral responses to chronic stress to try to find genetic mechanisms linked to vulnerability to stressful events.
In an earlier study, the research team, led by U.T. Southwestern psychiatry professor Eric Nestler, found that levels of BDNF — which is implicated in learning because of its role in creating stronger connections between neurons — increase in the nucleus accumbens
in response to chronic stress.
† Nicknamed the «stress hormone,» cortisol production increases in
response to chronic stress.
Excessive cortisol production in
response to chronic stress may produce a host of adverse health conditions.