The findings support the hypothesis that FOP lesions thrive in a hypoxic microenvironment, not simply due to oxygen deprivation, but also because of a
maladaptive response to hypoxia by the HIF - 1α molecular alarm, similar to that seen in cancer.
Insight into the novel role that NMDA receptors play in
retinal responses to hypoxia may be derived from study of the coordinated expression patterns of genes that interact, either directly or indirectly, with the NMDA receptor; namely, the NMDA interactome.
A major aspect of this process is the production of multiple angiogenic cytokines and growth factors
in response to hypoxia / ischemia, which is mediated by the transcription factor HIF - 1 (hypoxia - inducible factor 1).
«Now, with the help of gene therapy and stem cells we can help reactivate the body's
response to hypoxia and save limbs.»
These enzymes regulate genetic programs in
response to hypoxia, a common feature deep inside tumors.
That response was even better during certain stages of the menstrual cycle in younger female rats, suggesting female hormones play a role in
the response to hypoxia during sleep.