Sentences with phrase «response to immunotherapy»

The researchers say a strategy is needed to improve responses to immunotherapy drugs, and to make the responses to the drugs last longer.

Melanoma has shown the most promising response to immunotherapy vaccines, according to researchers.

«Our findings point to two potential impacts from additional research — analyzing the diversity and composition of the microbiome to predict response to immunotherapy and modulating the gut microbiome to enhance treatment,» said Wargo, senior researcher on the project and co-leader of the Melanoma Moon Shot ™, part of MD Anderson's Moon Shots Program ™ to reduce cancer deaths by accelerating development of therapies from scientific discoveries.

Also, individuals with genotypes associated with better response to immunotherapy may receive priority for treatment.

For example, new data has shown that tumors that are infiltrated by T cells — a type of white blood cell that plays an important role in immunity — translate to better outcomes in response to immunotherapy.

Additionally, this team hopes to identify features that drive patient responses to immunotherapy and gain insight into additional strategies for converting immunotherapy resistant tumors into tumors that respond to treatment.

«Our research sheds light on the mechanism of this impairment, pointing us in the direction of new strategies for improving the response to immunotherapy.»

However, tolerance - inducing mechanisms and the presence of suppressive cell types in the tumor microenvironment can dampen the response to immunotherapy.

Schneck says some scientists have emphasized that response to immunotherapy is largely dependent on whether T - cells are infiltrating the tumor site, but his research suggests that while, «infiltration is important, it's not enough to explain patients» variable responses to immunotherapy drugs.»

Generally tumors that happen in older people have more mutations, and for other kinds of cancers the number of mutations has been found to be related to the response to immunotherapy: Older people can have tumors that have more mutations and sometimes they can be more responsive to immunotherapy but, really, it's just luck; there's no hard - and - fast rule about age being related to response to immunotherapy.

The researchers decided to run a small trial, led by Hopkins immunologist Dung Le and geneticist Diaz, to determine whether the defect could predict a patient's response to immunotherapy.

«We wanted to see if there would be a correlation between the beta blockers patients were taking for another condition and their response to immunotherapy.

In particular, the goals are to investigate patient epigenetic variation that influences the response to immunotherapy and to use epigenetic therapeutics alone or in combination with immunotherapy to inhibit tumor progression as well as to overcome resistance to immunotherapy.

Fortunately, he said, there have been advances in understanding the relationship between the immune system and breast cancer and the difference between subtypes and their response to immunotherapy.