Sentences with phrase «response to insulin signaling»

Foxo is widely expressed throughout the body (both in flies and in humans), particularly in muscle, the liver and pancreas — and can regulate many aspects of metabolism in response to insulin signaling.

Not exact matches

Previously, longevity researchers believed dietary restriction was regulated via an insulin - signaling pathway, where the levels of the nutrient - sensing hormone would fall in response to lowered food intake, activating a DNA - binding protein called daf - 16 that would then confer longevity through the regulation of genes under its control.

In the brain, these signals tell the nerves controlling each specific organ what the proper response is — for example, digestive processes and release of insulin — according to the signals detected in the GI tract.

Besides lipotoxicity (see section V.N) many other molecular mechanisms are involved, including mitochondrial dysfunction, oxidative stress, intramyocardial inflammation, involvement of the reninangiotensin system, altered insulin signaling or female - specific cardiac glycogen handling as a response to metabolic stress (308), and sex - hormone related myocardial calcium handling (309).

Insulin signaling and the general amino acid control response: two distinct pathways to amino acid synthesis and uptake

In response to the concentration of dietary amino acids, the fat body secretes a peptide signal into the insect bloodstream that regulates the systemic release of important growth - regulating peptides, the insulin - like peptides.

Quantitative measurement of proteins involved in insulin signaling and central metabolism in C57BL / 6J and 129Sv mice subjected to a sustained high ‐ fat diet reveals that the two strains diverge early in their response to the feeding regimen.

Responses to reduced insulin / IGF signaling are highly tissue ‐ specific, influencing different processes in different tissues.

The augmented anabolic response to amino acids and insulin was shown to be due to an increased activation of the mTOR / p70S6K signalling pathway, which is considered an integral control point for muscle protein anabolism and muscle cell growth.

In humans, the signaling mechanism that slows autophagic recycling is identical to the signaling mechanisms that control our response to insulin and insulin - like growth factor, thus it can also be called the insulin mechanism.

Since glutathione and cysteine concentrations are relatively low in the post-absorptive state, especially in older individuals, NAC is best taken early in the morning and before retiring for the night — several hours after consumption of the evening meal to ensure a postabsorptive state (i.e., that normal insulin signaling in response to food intake is not occurring).

Regarding cell response, cell signaling specific to insulin resistance was improved by 160 mcg of Chromium a day and 200 mg of magnesium a day in both genders.

Consider the paper mentioned above finding that diabetics who fasted until noon experienced an exaggerated blood glucose response to food via inhibition of normal insulin signaling.

Some of the most promising candidate genes appear to be those involved in regulatory pathways such as insulin signaling, immunoinflammatory response, stress resistance or cardiovascular function.»

This response seems to happen because the continued rise of intracellular amino acid levels signal to limit the rate of protein breakdown.4 It is thought that this signal to decrease breakdown is due to the action of insulin and has no limit, as protein breakdown will continue to decrease with ever increasing protein intake.