They bred mice to express light - sensitive proteins in their acid - sensing TRCs, which make the cells fire in
response to light from a laser.
Not exact matches
Actual results, including with respect
to our targets and prospects, could differ materially due
to a number of factors, including the risk that we may not obtain sufficient orders
to achieve our targeted revenues; price competition in key markets; the risk that we or our channel partners are not able
to develop and expand customer bases and accurately anticipate demand
from end customers, which can result in increased inventory and reduced orders as we experience wide fluctuations in supply and demand; the risk that our commercial
Lighting Products results will continue to suffer if new issues arise regarding issues related to product quality for this business; the risk that we may experience production difficulties that preclude us from shipping sufficient quantities to meet customer orders or that result in higher production costs and lower margins; our ability to lower costs; the risk that our results will suffer if we are unable to balance fluctuations in customer demand and capacity, including bringing on additional capacity on a timely basis to meet customer demand; the risk that longer manufacturing lead times may cause customers to fulfill their orders with a competitor's products instead; the risk that the economic and political uncertainty caused by the proposed tariffs by the United States on Chinese goods, and any corresponding Chinese tariffs in response, may negatively impact demand for our products; product mix; risks associated with the ramp - up of production of our new products, and our entry into new business channels different from those in which we have historically operated; the risk that customers do not maintain their favorable perception of our brand and products, resulting in lower demand for our products; the risk that our products fail to perform or fail to meet customer requirements or expectations, resulting in significant additional costs, including costs associated with warranty returns or the potential recall of our products; ongoing uncertainty in global economic conditions, infrastructure development or customer demand that could negatively affect product demand, collectability of receivables and other related matters as consumers and businesses may defer purchases or payments, or default on payments; risks resulting from the concentration of our business among few customers, including the risk that customers may reduce or cancel orders or fail to honor purchase commitments; the risk that we are not able to enter into acceptable contractual arrangements with the significant customers of the acquired Infineon RF Power business or otherwise not fully realize anticipated benefits of the transaction; the risk that retail customers may alter promotional pricing, increase promotion of a competitor's products over our products or reduce their inventory levels, all of which could negatively affect product demand; the risk that our investments may experience periods of significant stock price volatility causing us to recognize fair value losses on our investment; the risk posed by managing an increasingly complex supply chain that has the ability to supply a sufficient quantity of raw materials, subsystems and finished products with the required specifications and quality; the risk we may be required to record a significant charge to earnings if our goodwill or amortizable assets become impaired; risks relating to confidential information theft or misuse, including through cyber-attacks or cyber intrusion; our ability to complete development and commercialization of products under development, such as our pipeline of Wolfspeed products, improved LED chips, LED components, and LED lighting products risks related to our multi-year warranty periods for LED lighting products; risks associated with acquisitions, divestitures, joint ventures or investments generally; the rapid development of new technology and competing products that may impair demand or render our products obsolete; the potential lack of customer acceptance for our products; risks associated with ongoing litigation; and other factors discussed in our filings with the Securities and Exchange Commission (SEC), including our report on Form 10 - K for the fiscal year ended June 25, 2017, and subsequent reports filed with
Lighting Products results will continue
to suffer if new issues arise regarding issues related
to product quality for this business; the risk that we may experience production difficulties that preclude us
from shipping sufficient quantities
to meet customer orders or that result in higher production costs and lower margins; our ability
to lower costs; the risk that our results will suffer if we are unable
to balance fluctuations in customer demand and capacity, including bringing on additional capacity on a timely basis
to meet customer demand; the risk that longer manufacturing lead times may cause customers
to fulfill their orders with a competitor's products instead; the risk that the economic and political uncertainty caused by the proposed tariffs by the United States on Chinese goods, and any corresponding Chinese tariffs in
response, may negatively impact demand for our products; product mix; risks associated with the ramp - up of production of our new products, and our entry into new business channels different
from those in which we have historically operated; the risk that customers do not maintain their favorable perception of our brand and products, resulting in lower demand for our products; the risk that our products fail
to perform or fail
to meet customer requirements or expectations, resulting in significant additional costs, including costs associated with warranty returns or the potential recall of our products; ongoing uncertainty in global economic conditions, infrastructure development or customer demand that could negatively affect product demand, collectability of receivables and other related matters as consumers and businesses may defer purchases or payments, or default on payments; risks resulting
from the concentration of our business among few customers, including the risk that customers may reduce or cancel orders or fail
to honor purchase commitments; the risk that we are not able
to enter into acceptable contractual arrangements with the significant customers of the acquired Infineon RF Power business or otherwise not fully realize anticipated benefits of the transaction; the risk that retail customers may alter promotional pricing, increase promotion of a competitor's products over our products or reduce their inventory levels, all of which could negatively affect product demand; the risk that our investments may experience periods of significant stock price volatility causing us
to recognize fair value losses on our investment; the risk posed by managing an increasingly complex supply chain that has the ability
to supply a sufficient quantity of raw materials, subsystems and finished products with the required specifications and quality; the risk we may be required
to record a significant charge
to earnings if our goodwill or amortizable assets become impaired; risks relating
to confidential information theft or misuse, including through cyber-attacks or cyber intrusion; our ability
to complete development and commercialization of products under development, such as our pipeline of Wolfspeed products, improved LED chips, LED components, and LED
lighting products risks related to our multi-year warranty periods for LED lighting products; risks associated with acquisitions, divestitures, joint ventures or investments generally; the rapid development of new technology and competing products that may impair demand or render our products obsolete; the potential lack of customer acceptance for our products; risks associated with ongoing litigation; and other factors discussed in our filings with the Securities and Exchange Commission (SEC), including our report on Form 10 - K for the fiscal year ended June 25, 2017, and subsequent reports filed with
lighting products risks related
to our multi-year warranty periods for LED
lighting products; risks associated with acquisitions, divestitures, joint ventures or investments generally; the rapid development of new technology and competing products that may impair demand or render our products obsolete; the potential lack of customer acceptance for our products; risks associated with ongoing litigation; and other factors discussed in our filings with the Securities and Exchange Commission (SEC), including our report on Form 10 - K for the fiscal year ended June 25, 2017, and subsequent reports filed with
lighting products; risks associated with acquisitions, divestitures, joint ventures or investments generally; the rapid development of new technology and competing products that may impair demand or render our products obsolete; the potential lack of customer acceptance for our products; risks associated with ongoing litigation; and other factors discussed in our filings with the Securities and Exchange Commission (SEC), including our report on Form 10 - K for the fiscal year ended June 25, 2017, and subsequent reports filed with the SEC.
If you get no
responses from one boss, find someone else
to green
light your decision.
A conditional commitment should not stop you
from asking the important questions as you proceed, but bear in mind that it might affect the willingness of your buyer
to part with certain information, something which can be interpreted in
light of the buyer's
response mode as well.
«As an example of the supply chain effect in
light of the high
response rate
from the construction and real - estate industries, the increased costs
to this sector could potentially translate
to consumers.
First, it is trying
to articulate how contemporary rock seems
to be in a pattern of Perpetual Repetition, but how that mode is different
from the Retro Rock and Roll stance that arose in the late 70s / early 80s — this is very much a
response to, or a working out of my own thinking in the
light of, Simon Reynolds» fine book Retromania.
In the
light of this analysis, then, my own scenario is cautiously hopeful, depending on (1) whether a creative minority of dreamers and doers with visions of a new life - fulfilling social order really emerges in strength, (2) the alliances that can be worked out with blacks, the poor, and other minorities now excluded
from major social benefits, (3) the extent
to which the populist idealism of the lower middle classes and working people generally favoring the extension of rights and equality
to the «little man» everywhere wins out over the reactionary fears and prejudices which establishment elites and opportunist politicians are all too willing
to exploit, and (4) what takes place at the center of the political spectrum itself under the pressure of events and in
response to challenges
to the established system
from militant seekers of change.
Later, through the lips of her companion she made a brief
response, thanking them for «a deed of generosity
from the masters of knowledge and
light to those who live under the covert of denial.»
Glen took issue with Geisler's
response to Hiebert, particularly in
light of his own daily interaction with people
from many different backgrounds:
But this recipe begged a
response from me and dragged me
to the
light.
Besides several teams who have questions surrounding one or possibly two players, there is no squad that has so many issues heading into the final week of the transfer window... even Monaco, who have lost numerous players
from their starting 11 have less controversy swirling in and around their club and they have champion's league play
to contend with this season... just think of how ridiculous this situation is especially considering that we have had the same manager for over 20 years... no team should be better organized than ours... if nothing else, that should be the one advantage this team holds over all others, yet the exact opposite has occurred... this fact is even more disturbing considering the main argument against removing Wenger
from his managerial position was that there was no suitable replacement and that people feared some sort of perceived drop - off if a new manager was brought into the mix... based on what we've witnessed since the time of his contract renewal a monkey with a magic eight ball could have done an adequate job... I hate
to make jokes, in
light of our current dilemma, but this team is so screwed up if I don't laugh about it, the only plausible
response is
to either cry or do something incredibly destructive... just look around this squad and try
to see what our delusional manager sees that allow him
to make such positive statements about our current team
The Spanish tactician will surely be hoping for that type of
response from Mangala, as ultimately he doesn't want
to be left even
lighter in defence as his side looks set
to compete on various fronts this season.
In the prophetic singer's
response to the question
from the host, as
to whether there are fake pastors or not, he can not tell but what he believes is that «Fake is good, it helps throw
light on the original».
The on topic Q&A included redesign plans for other streets, especially Queens Boulevard, why the administration attributes the reduction in pedestrian fatalities
to Vision Zero and not
to regular year -
to - year variances, how the administration actually knows that driving speeds are reduced, why so few street redesign projects have been done on Staten Island, data for any changes in safety at this E.Tremont / Silver Street intersection, why Commissioner Bratton did not attend, why there are few speeding and failure
to yield tickets issued in this (45th) precinct, the negative effect of speed bumps on emergency
response vehicles, plans for marking and painting of roads, whether the mayor will seek additional red
light camera authorizations
from the state legislature, the paucity of criminal prosecutions against drivers who kill pedestrians and an estimate of money received
from speed camera tickets.
But Howe's involvement, which Upstate acknowledged only last week in
response to questions
from syracuse.com, sheds new
light on a deal that gave Cor a valuable public asset without requiring much
from the developer in return.
Because these LEDs get their
lighting from organic compounds that glow in
response to electric current, they can be thinner,
lighter and more flexible than LCDs.
The herbicide is a synthetic analog of the plant hormones called auxins, which control everything
from the plant's
response to light and gravity
to the ripening of fruit.
This process, Ramirez noted, suggests that
light sensors are connected
to the chromatophores and that this enables a
response without input
from the brain or eyes.
In order
to record the skin's sensitivity across the spectrum, Ramirez exposed octopus skin
to different wavelengths of
light from violet
to orange and found that chromatophore
response time was quickest under blue
light.
Elsie would move in
response to light, including beams that it would emit
from its own tortoise - like body.
Running low - power laser
light, akin
to that
from a typical laser pointer, through the rings generates a tunable
response — either attractive or repulsive, depending on the wavelength — that changed the size of the gap between the rings by as much as 20 nanometers.
The study, titled «Subset of heat - shock transcription factors required for the early
response of Arabidopsis
to excess
light,» was led by researchers
from Dartmouth, the Salk Institute for Biological Studies and Australian National University.
Others have printed photoactivated structures
from polymers that shrink and stretch in
response to light.
He discovered that there is a signal sent
from the chloroplast in
response to light, which then activates gene expression in the nucleus
to make the plant resistant
to heat stress.
The brains of humans and dogs
light up in the same place in
response to vocal sounds, suggesting these processing areas are inherited
from a common ancestor
A new genetic therapy not only helped blind mice regain enough
light sensitivity
to distinguish flashing
from non-flashing
lights, but also restored
light response to the retinas of dogs, setting the stage for future clinical trials of the therapy in humans.
Each fly neuron's
response to constant
light jittered up and down
from one millisecond
to the next.
«Melanopsin is a part of our visual system
from long ago in evolution, and it controls several important biological
responses to light,» said lead author, Manuel Spitschan, PhD, who received his doctorate
from the Psychology program at Penn in 2016 and is now a Sir Henry Wellcome Postdoctoral Fellow at the University of Oxford.
Researchers
from the MRC CDN, led by Professor Oscar Marín, have shed
light on this problem by discovering that some neurons in the cerebral cortex can adapt their properties in
response to changes in network activity — such as those observed during learning of a motor task.
Using molecular switches that expand and contract in
response to different wavelengths of
light, two teams of scientists have constructed nanoscale gateways that could someday be used for everything
from precisely - controlled drug delivery
to brewing super-cooled nanofluids.
In the journal Optical Materials Express,
from The Optical Society (OSA), the researchers reported that graphene oxide sheets treated with brief exposure
to bright
light in the form of a camera flash exhibited reversible bending at angles
from zero
to 85 degrees in
response to switching the relative humidity between 33 and 86 percent.
Countdown timers that let motorists know when a traffic
light will go
from green
to yellow lead
to safer
responses from drivers, research at Oregon State University suggests.
The drops work by opening the pupil and preventing the iris
from constricting in
response to light and are often used for routine examination and photography of the back of the eye.
Experiments on cells
from frogs have shown that sensitive
light - detecting cells in vertebrate eyes, called rod cells, do fire in
response to single photons.
Since individual clouds have a life time of hours, and the CRF - interpretation involves changes in the reflected
light as well as ionisation, a climatic
response from change in CRF is hypothetically almost instantaneous, and it is a challenge
to explain why the night side (where there is no sunlight and hence reflection can not play a role) warms more strongly than the dayside, if the CRF were
to drive the recent warming trend.
The team measured the pupils»
response to light and examined the brains» visual
response centers
to show that signals
from the eye were going
to the appropriate areas of the brain.
Changing my source of B vitamins, going on a low histamine / low sulfur diet, and detoxing with infrared
light and ionic foot baths in
response to what was learned
from my genetic information is turning things around for me.
Promotes healthy cellular
response to UV
light to protect skin
from damage and help prevent age related skin changes.
The soundtrack is comprised of original tunes that really serve
to capture the essence of Minecraft and complement the action unfolding on the screen perfectly, effectively striking the appropriate emotional
response from the player on a consistent basis as the story becomes darker in tone after the
light - hearted opening sequences.
They hoke up meaningful stories such as «We Are Marshall» and «Friday Night
Lights»
to get facile, unquestioned, reflexive
responses from their audience.
But at the same time there are flexible legal mechanisms
to accommodate imperatives arising
from the
responses that states need
to provide in
light of the deepening economic and financial crisis after 2008.
But at the same time these same laws offer flexible legal mechanisms
to accommodate imperatives arising
from the
responses that states need
to provide in
light of the deepening economic and financial crisis.
The DfE claimed it had omitted UTCs and studio schools
from the target in
light of consultation
responses, adding: «We decided that it is not appropriate
to expect the same rates of EBacc entry... as in mainstream schools.»
Both provide a rich stream of information
to the driver with garrulous steering, sharp throttle
response and delightfully swift five - speed gearshifts, while even a lack of power assisted steering can't hide the agility that comes
from such
light kerbweights.
The person who created the Starlight Headliner: Alan Sheppard Head of Colour, Materials, and Accessories, Rolls - Royce Motor Cars
To create a strong emotional response, we started researching how to get ambient light from the headline
To create a strong emotional
response, we started researching how
to get ambient light from the headline
to get ambient
light from the headliner.
From the get go it feels light and responsive and benefits from the quick and direct steering similar to the Giulia Quadrifoglio's, giving it a Golf R style of response rather than that of a tallish SUV weighing the wrong side of 1800
From the get go it feels
light and responsive and benefits
from the quick and direct steering similar to the Giulia Quadrifoglio's, giving it a Golf R style of response rather than that of a tallish SUV weighing the wrong side of 1800
from the quick and direct steering similar
to the Giulia Quadrifoglio's, giving it a Golf R style of
response rather than that of a tallish SUV weighing the wrong side of 1800 kg.
Front lower arms and rear brake calipers fashioned
from aluminum and special lightweight wheels contribute
to lightened unspring mass, resulting in
lighter handling and
response.
12 Months GOLD Warranty included... LOW MILEAGE with FULL LANDROVER SERVICE HISTORY, NEW MOT, Stunning car finished in striking Firenze red metallic with Red / black leather interior, Touch screen Satellite Navigation, Colour reversing camera with front and rear sensors, Cruise control, 20inch V spoke Alloy wheels, Duel zone climate control, Heated electric seats, Electric folding mirrors, Electric windows, Terrain
response, Hill start assist and descent control, 380watt Meridan surround sound speaker system, Leather steering wheel, Keyless push button starts, Remote central locking, 2keys, Drivers / passengers / side airbags, Cd player, Bluetooth, Fog
lights, DRL led
lights, Colour coded paintwork, Really needs
to be viewed / driven
to appreciate, We are located in Weston super mare just off Junction21 of the M5 within walking distance of the WSM train station and only 20 mins
from Bristol Airport.
LED lamps also offer near - instant
response, giving valuable extra warning time for following traffic - LED Cargo Box and Side Mirror
Lighting: Advanced, powerful yet efficient LED lighting brightly lights the cargo box and job site after the sun goes down with minimal battery drain compared to standard headlights or plug - in lights - Hidden Cargo Ramps: Lightweight, durable loading ramps stowed below the cargo box can be quickly removed and set up to assist with loading wheeled items into the bed — from landscaping equipment to di
Lighting: Advanced, powerful yet efficient LED
lighting brightly lights the cargo box and job site after the sun goes down with minimal battery drain compared to standard headlights or plug - in lights - Hidden Cargo Ramps: Lightweight, durable loading ramps stowed below the cargo box can be quickly removed and set up to assist with loading wheeled items into the bed — from landscaping equipment to di
lighting brightly
lights the cargo box and job site after the sun goes down with minimal battery drain compared
to standard headlights or plug - in
lights - Hidden Cargo Ramps: Lightweight, durable loading ramps stowed below the cargo box can be quickly removed and set up
to assist with loading wheeled items into the bed —
from landscaping equipment
to dirt bikes
If you want
to get away
from that stop
light in a hurry, then that's about the only time the Niro disappoints with a slower than expected
response.