The GCN2 - ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation
The relatively new sciences of nutrigenetics and nutrigenomics study how genetic variation
affects response to nutrients and how nutrition affects genetic expression.
Zavolan's group will now investigate whether the mammalian homolog similarly slows aging and extends lifespan by regulating protein synthesis genes
in response to nutrients and stress.
However, an overactive stimulation of mTOR in
response to nutrients and growth factors — metabolic processes that are crucial in tumor biology — leads to an increase in cell growth and proliferation.
In the past 27 years, we have found that this cycling sugar modification of proteins — called O - linked N - acetylglucosamine, or O - GlcNAc — is nearly as common as protein phosphorylation and often competes with it at the same or proximal sites on proteins to regulate nearly every cellular process in
response to nutrients and stress.
TOR plays many roles, but one of its primary tasks is to function like a wrench loosening and tightening the control of protein synthesis in
response to nutrients, specifically amino acid availability.
BETHESDA, MD, — The Foundation for the National Institutes of Health (FNIH) has selected Whitehead Institute Member David Sabatini to receive its fifth annual Lurie Prize in Biomedical Sciences for discovery of the mTOR (mechanistic target of rapamycin) cellular pathway as a key regulator of growth and metabolism in
response to nutrients.