Sentences with phrase «response to viruses for»

The rationale for selecting CPV and CDV for serum antibody testing is based on the clinically important diseases they cause, combined with the usefulness of the host's humoral immune response to these viruses for determining the need for revaccination.

Distinct and essential roles of transcription factors IRF - 3 and IRF - 7 in response to viruses for IFN - α / β gene induction.

Not exact matches

As reported by the New York Post's Yoav Gonen, Kavanagh joined Mayor Bill de Blasio and New York City Health Commissioner Dr. Mary Bassett for a press briefing on the City's proactive response to the threat of the Zika virus, and the need for Congress to fund a robust, decisive effort by the federal government — in New York and especially in warmer places where mosquitoes known to transmit the virus are prevalent — to avert a health crisis in the United States.

The New York City health department will no longer monitor people returning from West Africa for the Ebola virus, officially ending the city's response to the epidemic.

Speakers included Dimitri Prybylski of the U.S. - based Centers for Disease Control (CDC), Namibia office, who was involved in coordinating the international response to the Ebola virus outbreak in West Africa; Markus Theobald of the EU Delegation to Namibia in Windhoek; and Pierguido Sarti, Italian science attaché to South Africa, Namibia, and other southern African countries.

Michael Osterholm, director of the University of Minnesota's Center for Infectious Disease Research and Policy in Minneapolis, points out that the 2004 document was based on input from an international panel of 22 scientists and public - health officials, in response to the threat of the deadly H5N1 avian flu virus.

«In that paper, we found a common response by the human immune system to multiple viruses that is distinct from that for bacterial infections.

Future studies are needed to better define the molecular mechanism behind TREML4 - induced amplification of TLR7 signaling and to clarify beneficial reactions controlled by TREML4 — for example, the immune response to influenza virus, which the current study found was inhibited by TREML4 deficiency.

«The first line of defense of the immune system, the innate immune response, is not acting quickly enough to clear the virus,» says co-lead author Gülsah Gabriel, a virologist at the Heinrich Pette Institute, Leibniz Institute for Experimental Virology in Hamburg, Germany.

The UNC research team, led by Lemon and Jason Whitmire, Ph.D., Associate Professor in UNC's Department of Genetics, is now poised to investigate the complicated interplay of nonspecific «innate» and specific «adaptive» immune responses that ultimately control the infection and eliminate HAV from the host — processes that are not well understood for any of the five human hepatitis viruses.

Unlike PCR - based tests, which look for the presence of the virus's genetic material, the ReEBOV test detects antigens: proteins made by the body in response to an Ebola infection.

But there's a catch: viruses and tumour cells can also exploit the UPR for their own ends, enabling them to grow at a faster rate and to thwart the body's immune response.

By hijacking the cricket fat body, the virus established itself more easily by knocking out part of the cricket immune response, a necessary tactic for any parasite to avoid being detected and destroyed by their host.

The findings are significant because it helps researchers further understand the immune response to a virus such as Ebola and could lead to treatments for Ebola as well as other related viruses.

Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.

Analysis of daily gene activation in a patient with severe Ebola virus disease cared for at the National Institutes of Health (NIH) in 2015 found changes in antiviral and immune response genes that pinpointed key transition points in the response to infection.

Researchers compared the inflammatory response of control - treated versus simvastatin - treated cells to RV by measuring CXCL10 secretion, an implicated therapeutic target for virus - induced asthma exacerbations.

Several previous studies have explored whether drugs can shock cells that are infected with latent HIV to make new viruses, setting them up for the kill by the natural immune response.

In response to growing criticism about the lack of access to influenza data, the Centers for Disease Control and Prevention (CDC) in Atlanta, Georgia, on 22 August made public the sequence of more than 650 genes from flu viruses isolated in the United States.

For this, a vaccine response more rapid than the spread of the virus and one that can stop damage to the cells is sufficient.

«This improved understanding of the host response to HCV infection, and the HCV entry process, will provide new direction for the development of therapeutic treatments to either heighten this natural response, or generate mimics to target the virus specifically.»

Virologists at the European Flu Summit in Brussels last week told New Scientist that early results show 13 times more H7N9 virus is needed to elicit a protective immune response than is needed for ordinary flu.

Response efforts for Zika virus and its associated diseases are taking place in parallel with efforts to better understand the virus» many unknowns, including the length of the Zika infectious period and the efficacy of control methods.

Gene therapy, which often employs viruses to deliver the good genes to a body's target cells, has been known to trigger severe immune responses and was blamed for the death of an 18 - year - old in 1999, who was receiving gene therapy for a hereditary metabolic disorder.

Our study suggests that the immune response to an early infection, HSV - 2, may be the additional factor that increases the risk for severity of Zika virus - induced disease,» said Dr. Gil Mor, senior author of the American Journal of Reproductive Immunology study.

These latter two cell types can mount effective immune responses to viruses and tumors; whereas, exhausted T cells fail and memory T cells, in particular, for long - lasting durable effects.

Experiments with mouse embryo support cells that express mutant DUB or pseudo-DUB proteins show an impaired immune response when infected with a virus and impaired DNA damage repair when exposed to ionizing radiation, further validating the need for complex's correct structure.

The DNA vaccine for Zika virus is more immunogenic and effective than other vaccines because it can create memory responses, which inactivated vaccines with killed viruses fail to produce, Higgs said.

Corbett will collect blood samples to search for a specific antibody response to the dengue virus, a key step in creating a vaccine for the world's most widespread mosquito - borne disease.

Research programs of Immunopathology Unit aim to dissect the cellular and molecular mechanisms responsible for immunopathological responses of the liver, with emphasis on the responses that occur during infection with hepatitis B virus (HBV).

vector - a bacterium or virus that does not cause disease in humans and is used in genetically engineered vaccines to transport genes coding for antigens into the body to induce an immune response.

If the patient is able to mount a strong immune response that controls virus replication they can ultimately reduce the level of virus in their blood to a level beyond detection, effectively zero for clinical purposes.

More to the point, by genetically stripping dengue virus of its ability to bind 14 -3-3 epsilon, Gack has generated a crippled virus that can elicit a strong human immune response, providing a framework for rational vaccine design against emerging infectious diseases.

Agonist reagents that stimulate OX40 also have great potential therapeutically for vaccination, as shown by a number of studies in tumor models or of responses to viruses where the immune response can be boosted dramatically to aid protection.

Other research is investigating whether agonist reagents that can signal various immune cells such as T cells, dendritic cells, or NK cells, through the TNF family receptors OX40, 4 - 1BB, HVEM, or LTβR can be used to increase natural immune responses to viruses or tumors that might lead to new strategies for vaccination.

The vaccines were evaluated for immunogenicity and efficacy; however, because of the previous report of immunopathology on challenge of ferrets and nonhuman primates that had been vaccinated with a whole virus adjuvanted vaccine and mice that had been vaccinated with a VLP vaccine, the primary orientation was to assess for immunopathology among animals in relation to type of vaccine, dosage, serum antibody responses, and virus infection.

The laboratory of Linda Bradley, Ph.D., professor at SBP, recently published a paper identifying PSGL - 1, a protein that limits T cell responses to viruses, as a new target for checkpoint inhibition, an approach akin to taking the «brakes» off the immune system.

Rather than using a killed or attenuated virus to develop a vaccine for dengue, de Silva's lab is focusing on «expressing the E protein and attaching it to nanoparticles to induce good immune responses,» Metz said.

Through long - established collaborations in Durban and Kimberley, these studies in particular seek to define: the immune responses that are effective in control of HIV infection; the impact of HLA - mediated selection pressure on HIV at the individual and population level; the mechanisms of HIV non-pathogenicity; the nature and consequences of ontogeny of the virus - specific immune response; and finally the prospects for interventions including antiretroviral therapy, alone or in combination with broadly neutralising antibodies and / or T - cell vaccines, to achieve HIV eradication.

But for scientists who develop therapeutic viruses (to, for example, target cancer cells or correct gene deficiencies) a more important question is: How do we keep people's natural immune responses at bay?

Mutations in RNAse L that impair the apoptotic response to viral infection were postulated to reflect enhanced susceptibility to infection by XMRV and suggested a potential role for the virus in carcinogenesis [5], [6], [7], [8].

The authors» intention, they wrote, was for this comprehensive analysis to «provide a framework for predicting the behavior of future outbreaks for Ebola virus» and other human pathogens and to guide targeted, life - saving responses.

Most HIV tests (including test kits for home use) detect antibodies that your body produces in response to the virus.

The body correctly perceives the food to be foreign and mounts a response to destroy and remove the offending food, much like it would for a bacteria or a virus.

Nutrient deficiency is one of the main reasons for a cytokine storm in response to a virus like H1N1, along with heavy metals and other chemicals that are flooding out of the cells when one has the flu.

Regarding treatment for Canine Infectious Hepatitis, the virus will typically eventually run its course, but aforementioned supportive are sometimes useful in stabilizing the patient to enable the mounting of an effective immune response to hasten recovery.

On the other hand, some birds will be tested for PDD with the PCR at a point when they are no longer shedding the virus, but later go on to develop the disease owing to the inflammatory immune response.

This release time gives more time for the immune system to develop a response to the virus.1

The flaw in this logic is that there are studies that demonstrate that vaccines for the same virus administered closer to two weeks apart may interfere with each other — and lead to DECREASED immune response.

It takes up to 14 days for the immune system to complete its response to a modified live virus vaccination for canine viruses.