Sentences with phrase «responses by immune cells»

The experiments indicated that when dectin - 1 recognizes tropomyosin in house dust mites, shrimp or other common allergy - triggering species it suppresses airway cells» production of an immune molecule, IL - 33, which otherwise would promote an allergic response by immune cells.

Not exact matches

The tattooing process works by injecting ink into the skin, which stimulates an immune response in which cells called «macrophages» move into the area and «eat up» the ink.

Turnips are high in vitamins A and C; antioxidants that together play an important role in stimulating the body's immune response by boosting the formation of antibodies and white blood cells.

Beta - carotene has been found to reduce cell damage caused by free radicals, and improves immune function by enhancing cell mediated immune responses.

We found that when it comes to cutaneous immunity — specific to skin — the immune system was being obstructed by skin cells that were too prone to producing inflammation responses.

An immune response, triggered by foreign neural stem cells, could actually help attack tumors, says Evan Snyder, a stem cell biologist at Sanford Burnham Prebys Medical Discovery Institute in San Diego, California, and one of the early pioneers of the idea of using stem cells to attack tumors.

Researchers found that NAD +, a natural molecule found in living cells, plants and food protects against autoimmune diseases by altering the immune response and turning «destructive» cells into «protective» cells.

«We're interrogating the tumor microenvironment,» she says, «by looking at suppressive cues as well as cells and secreted proteins that protect tumors from the immune response.»

Furthermore, the team found that ONA inhibited the pro-tumor functions of myeloid derived suppressor cells (MDSC), which are closely associated with the suppression of the anti-tumor immune response of host lymphocytes, by using preclinical sarcoma model.

NKp46 was critical for the subsequent development of antiviral and antibacterial T cell responses, which suggests that the regulation of NK cell function by NKp46 allows for the optimal development of adaptive immune responses.

Loss of LKB1 by regulatory T cells was also associated with increased levels of signaling molecules or cytokines associated with the Th2 immune response, Kai said.

However, some mice experienced dangerous levels of brain swelling, a side effect of the immune response triggered by the engineered cells, the researchers said, adding that extreme caution will be needed to introduce the approach in human clinical trials.

Onion A increases anti-tumor immune response by inhibiting the immune suppression actions of macrophage and myeloid derived suppressor cells (MDSC).

ONA appears to activate anti-tumor immune responses by nullifying the immunosuppressive function of myeloid cells.

Using cells from cadavers, doctors have been experimentally transplanting pancreatic islets into humans for decades, but as many as 60 percent of the transplanted islets die immediately because they are cut off from their blood supply and are killed by an immune response due to direct injection into the bloodstream, and those that survive the transplant usually die within several months.

Published in the journal Frontiers in Neuroscience, the researchers have assembled strong evidence that the neurological decline common to these diseases is caused by «auto - inflammation», where the body's own immune system develops a persistent inflammatory response and causes brain cells to die.

But Acinetobacter also ramped down the production of regulatory T cells, which help prevent autoimmune diseases by dampening the immune response.

Prompted by studies suggesting immune responses can help repair the nervous system, Kipnis and his colleagues created mice that lack CD4 cells, a kind of T - cell.

The enzyme is produced by white blood cells called neutrophils, which play an important role in inflammatory and immune responses and may be a key contributor to the development of muscular dystrophy.

The release of several signals by skin cells that are dying contributes to the creation and spreading of the chronic immune response and hyper - proliferation and irregular differentiation of epidermis,» says Joan Manils, first author of the study and member of the mentioned department and post-doctorate researcher at the Trinity Biomedical Sciences Institute (Ireland).

Interferons are molecules produced by cells in response to viral or bacterial infection, and which act on neighboring cells to prevent the spread of the infection, shut down protein synthesis, and activate the immune system.

«When mosquitoes are infected with these viruses, there's a signal that lets the mosquito's cells know that they are infected, resulting in targeting of the virus by the mosquito's immune response.

Since a primary function of the dendritic cells is to present an antigen to T - cells, to activate the T - cells and begin the immune response, the researchers suspected that T - cell activation in the heart tissue, and perhaps heart - tissue injury caused by T - cells, might be central to the pathological heart enlargement that is called remodeling.

However, immune cells may be blocked by inhibitory molecules, which serve as checkpoints to alleviate or «turn off» the immune system response, Gu explained.

The reason for the reduced glucose levels associated with bacterial meningitis was believed to be the need for glucose as fuel by infiltrating immune cells in response to infection.

The protein sits on the surface of T cells and helps dampen the activity of the cells after an immune response, but tumors have found ways to hide from T cell attack by flipping on the PD - 1 switch themselves.

The function of these genes were involved in molecular maintenance strategies, such as DNA repair, chromosomal maintenance, immune response and programmed cell death The authors argue that the «slower rate of change in these functions is consistent with increased constraint on somatic cell maintenance as would be required in these relatively long - lived and large - bodied mammals, illustrated by the additional large and long - lived species with slower rates in these genes (e.g. double - strand break repair gene XRCC4 is also highly constrained in elephant.»

After initiating photoreceptor loss in the fish retinas, the researchers monitored the immune system's response by tracking the activity of three types of fluorescently labeled immune cells in and around the eye: neutrophils, microglia and peripheral macrophages.

Thus, Ebola appears to work not by preventing an immune response altogether but by moving so swiftly that the T cells do not have time to multiply enough to mount an effective counterattack.

Along with improved potency and safety, the system saves time by providing easy, ready - touse RNA reagents that also reduce cell toxicity by avoiding activation of cellular innate immune responses.

To investigate the relationship between temperature and immune response, Iwasaki and an interdisciplinary team of Yale researchers spearheaded by Ellen Foxman, a postdoctoral fellow in Iwasaki's lab, examined the cells taken from the airways of mice.

A close encounter with S. Typhimurium provokes an obvious response by the neutrophil: the initially round immune cell bulges out towards the bacterium, getting ready to make contact and ingest the intruder.

An additional mechanism to prevent the immune response from going «overboard,» the researchers conclude, is provided by a subset of T - cells called induced regulatory T - cells (iTreg cells).

A certain cytokine, or small protein that helps cells communicate during immune responses, can control whether immune cells promote or suppress inflammatory bowel disease, a finding that could lead to new treatments, according to a study led by Georgia State University.

Allison pioneered immune checkpoint blockade, an approach that treats the immune system, rather than the tumor directly, by blocking molecules on T cells that shut those attack cells down, protecting tumors from immune response.

To investigate that response in the context of HIV, the study grouped women by their CD4 cell count, a measure of immune system health.

Using near - infrared light, researchers have shown they can selectively activate an immune response by controlling the flow of calcium ions into the cell.

Mechanistic studies showed that IFN increases antitumor immune responses by enhancing antigen presentation to T cells by dendritic cells present in the tumor microenvironment.

Further investigation revealed that the increased susceptibility was due to a reduction in production by the innate lymphoid cells of IL - 22, a protein that plays a key role in the intestinal immune response.

New research shows that all - trans - retinoic acid (atRA), the active form of vitamin A, regulates immune system responses in the mouse intestine by controlling expression of the protein HIC1 in cells known as innate lymphoid cells.

Interestingly, the outbreak strain grew at a normal pace in cultured human white blood cells, apparently by subverting the immune response to its benefit.

In additional experiments, the NYU team showed that the TB - transporting dendritic cells had to first pass through the lungs — as would be expected in the natural course of the disease that is passed by someone breathing in infected droplets — before heading to the lymph nodes to elicit a strong immune response.

In a report to be published in the journal Cell Host & Microbe online June 11, researchers showed that immune - system - triggering TB proteins, or antigens, were able to prompt a larger, prolonged immune system response just by being transported from infected dendritic cells to uninfected ones.

An international research team headed by the rheumatologist Dr Andreas Ramming at Friedrich - Alexander - Universität Erlangen - Nürnberg (FAU) has now managed to identify an immune system cell type that can be used in a targeted attempt to control the inflammatory response in arthritis patients.

«Our study shows a whole new route, or bypass mechanism, for triggering the body's adaptive immune response to TB infection, a means by which infected dendritic cells cooperate with uninfected dendritic cells to activate T cells and respond to the infection,» says infectious disease specialist and study senior investigator Joel Ernst, MD, a professor at NYU Langone Medical Center.

In their latest study, researchers at La Jolla Institute for Allergy and Immunology identified a key signal that drives the commitment of immature Tfh cells into fully functional Tfh cells and thus driving the step - by - step process that results in a precisely tailored and effective immune response.

Several previous studies have explored whether drugs can shock cells that are infected with latent HIV to make new viruses, setting them up for the kill by the natural immune response.

A team led by principal investigator Donald M. O'Rourke, MD, an associate professor of Neurosurgery at Penn, and Marcela Maus, MD, PhD, showed that CART - EGFRvIII cells had an acceptable safety profile, crossed the blood - brain barrier, infiltrated the tumor, and prompted an immune response, resulting in reduction of the EGFRvIII tumor antigen in GBM cells.

Antibodies only bind to target cells Peptide antibodies developed by Kwak and co-discoverer, Hong Qin, Ph.D., assistant professor of Lymphoma / Myeloma, wipe out MDSCs in the blood, spleen and tumor cells of mice without binding to other white blood cells or dendritic cells involved in immune response.

Scientists have found a way to target elusive cells that suppress immune response, depleting them with peptides that spare other important cells and shrink tumors in preclinical experiments, according to a paper published online by Nature Medicine.