Sentences with phrase «responses during infection»

Zika Virus Antagonizes Type I Interferon Responses during Infection of Human Dendritic Cells.

Of particular interest is a possible association of temperature - dependent alternative splicing with the immune response during an infection with fever.

Not exact matches

Importantly, the enzyme can act as an inhibitor of potentially harmful responses during viral infection.

They found that STAT6 - IP prevented RSV - induced changes to airway cells called alveolar macrophages, which can promote asthma - like responses both during and following viral infections.

The researchers also infected pregnant mice that had the receptor for type I interferons with a viral mimic — a bit of genetic material that goads the body to begin its antiviral immune response — to see if the damage happened only during a Zika infection.

«The suggestion here is that IL - 27 normally limits the severity of disease during these viral infections in part by influencing the quality of T - cell responses,» Muallem said.

The most common form of anemia in the hospital setting is anemia of inflammation, which occurs when the body's immune response is activated during illness or infection.

They go on to suggest that «lowering levels of TNF may be an effective strategy in improving host defense against S. pneumoniae in older adults,» and that, «although it may be counterintuitive to limit inflammatory responses during a bacterial infection, [some existing] clinical observations and our animal model indicate that anti-bacterial strategies need to be tailored to the age of the host.»

During the first days of infection, a typical innate immune response will stop the spread.

If we don't encounter many pathogens during infancy, it doesn't learn to keep itself in check, and turns on inflammation — normally a response to infection — in inappropriate situations.

«If we can somehow modulate the activation of this pathway, then that will help to decrease the exaggerated inflammatory response that causes mortality during influenza infection.»

«Taken together, these studies show that the NK cell IL - 10 response is associated with extensive proliferation, either under in vitro conditions independent of infection, or in vivo during infection,» wrote the authors, including co-lead author and former Brown postdoctoral researcher Seung - Hwan Lee, who is now at the University of Ottawa.

While the observed differences of the individual steps were mostly modest, mathematical modeling suggested that even small delays in the trafficking of these immune cells will lead to reduced initiation of a WNV - specific antibody - response during the early stages after infection.

Following transmission by mosquitoes, the early specific (also called adaptive) immune response to WNV is thought to be dominated by antibodies, and, consistent with this, the researchers found that older mice had less potent WNV - specific antibody responses during the early phase of infection.

During inflammatory responses due to infection, trauma, or cancer, the body's immune system becomes highly activated in an attempt to fend off invading organisms, foreign bodies, or tumor cells.

These rogue genetic elements pepper the brain tissue of deceased people with the disorder and multiply in response to stressful events, such as infection during pregnancy, which increase the risk of the disease.

In healthy individuals, MDSCs regulate immune responses and tissue repair, and the population of these cells rapidly expands during inflammation, infection and cancer.

Studies by Shibo Jiang at Fudan University in Shanghai, China, and colleagues have found that the bit of the viral surface protein that attaches to a cell during infection — the binding site — only induces the right kind of antibody response.

«The animal that responded to therapy had a broad, strong response during the early acute phase of infection.

Along this line, our primary research goals are directed towards understanding how noncoding RNAs and their RNA - binding proteins are integrated in to the regulation of gene expression and modulation of the host immune response during ¿ - herpesviral infection.

Research programs of Immunopathology Unit aim to dissect the cellular and molecular mechanisms responsible for immunopathological responses of the liver, with emphasis on the responses that occur during infection with hepatitis B virus (HBV).

Some individuals may be better suited than others to work in high - risk job placements during an infectious disease outbreak because they are more likely to have an adequate response to a vaccine, or because their genotype is associated with a lower risk of developing severe infection.

Along this line, our primary research goals are directed towards understanding how noncoding RNAs and their RNA - binding proteins are integrated in to the regulation of gene expression and modulation of the host immune response during gammaherpesvirus infection.

Lastly, increased systemic inflammation seen during ageing is also apparent in chronic infections such HIV or cytomegalovirus, 10,15 obesity7 and individuals enduring chronic psychological stress.16 Similarly, the main features of immunosenescence are apparent in many of these conditions, including decreased antibody responses, increased infections, malignancies and also incidences of inflammatory associated disorders such as cardiovascular disease.7, 10,15,16 Inflammation and premature immunosenescence are, therefore, prevalent features of many common conditions of modern life, such as obesity and stress, and could have negative health consequences for large proportions of society well before old age is reached.

By integrating the sequence data and the associated metadata, we have established laboratory and bioinformatics - based methods that enable us to investigate scientific questions including: the tropism of ZIKV for dendritic cells and the antiviral response of the cells during infection (Bowen et al. 2017); investigating the phylogenetic diversity of strains obtained by Biodefense and Emerging Infections (BEI) Resources and distributed to virologists (manuscript in preparation); the genetic determinants of ZIKV host adaptation in C6 / 36 mosquito vs. Vero cells; and the diversity of ZIKV circulating in limited geographic regions, including Barbados, Colombia, and the state of Chiapas, Mexico.

The aims are to study the adaptive response and damage / repair mechanisms of the foetus and newborn to a poor pre - and perinatal environment as during severe preeclampsia (asphyxia, hypoxia, growth restriction), chronic intrauterine infections and perinatal insults related to hypoxia and inflammation.

Our results show that LCMV variants that emerge during infection in vivo play a crucial role in the suppression of virus - specific CTL responses and in the maintenance of virus persistence.

We next investigated the parasite load and the immune response in the brains of mice infected with attenuated Type I and Type III parasites during chronic infection.

It is possible that T. gondii causes a permanent change in the brain during acute infection, thereby not requiring continued parasite presence and an ongoing immune response.

This finding may have implications for the host immune response or barrier function during infection.

The work will be an important step towards understanding how immune function is controlled during immune responses to infection and cancer.

This may require further investigation into the innate immune responses during viral infection, and the application of this knowledge using hESC / iPSC - based technologies.

The delayed antiviral immune response allows the virus to remain undetected in the vagina, which can increase the risk of fetal infection during pregnancy.

During infection this allows immune responses to better counteract the virulence factors produced by pathogens.

Dynamic Longitudinal Antibody Responses during Borrelia burgdorferi Infection and Antibiotic Treatment of Rhesus Macaques

Temperature - Dependent Induction of Salicylic Acid and Its Conjugates during the Resistance Response to Tobacco Mosaic Virus Infection

«What's more, the dampened vaginal immune response is especially concerning, because it gives the virus more time to spread to the fetus if a woman is pregnant or becomes pregnant during the course of infection.»

Although vaccination induces an inflammatory response during pregnancy, the magnitude and the duration of response is much lower and shorter, respectively, for influenza vaccination than viral infection.27 Like infection, influenza vaccination during pregnancy has been reported to induce a transient increase in the levels of a number of proinflammatory cytokines, including interleukin 6, tumor necrosis factor α, and C - reactive protein.27 - 30 Studies on mice found an association between high interleukin - 6 levels during pregnancy and abnormal behavior and brain structure.19 However, in epidemiological studies, associations between maternal cytokine levels and ASD have been mixed.

Working closely with numerous groups both within and outside the Broad, Livny uses these methods to gain insights into the physiological responses of diverse pathogens to the host environment during infection, uncover inter-species differences in the expression of conserved functions that drive pathogenicity, and define signatures of transcriptional responses to antibiotic exposure that enable rapid diagnosis of antibiotic resistant strains.

As part of a wider investigation into the impact of micronutrients on psychiatric symptoms, many participants who experienced a yeast infection during their treatment showed a diminished response to the micronutrients.

As energy is diverted away from the gut during the fight - or - flight response, digestion and immune function is slowed or halted for long periods of time, which can rob us of key nutrients and expose the gut to infection and inflammation.

Infections can stimulate a specific type of immune response that the body tries to avoid during pregnancies.

4) Eosinophils — These cells become especially active during a parasitic infection or allergic response, and are responsible for releasing histamine.

However, it is fairly common to see Cerebellar Hypoplasia (an under - developed brain portion) in response to a Parvo Virus (feline distemper) infection in the mother cat during pregnancy.

Understand how to develop and implement protocols to prevent transmission of feline or zoonotic infections during the emergency response and when transferring rescued cats to other shelters or to adopters.

• Implemented 1200 outreach programs over a course of 5 years to raise awareness of potential risks and immediate ways of handling them • Saved an entire office (87) people from impending disaster by quickly evacuating them from the premises before the onset of a flood • Devise safety development plans in a bid to deal with natural or manmade disasters • Provide consultancy to businesses in regards to functional steadiness during emergencies • Analyze and plan for potential risks by performing risk assessment tasks to ward off dangers associated with infection outbreaks and disasters • Prepare safety exercises and drills and execute practice drills to prepare personnel for actual events • Communicate with emergency services in the event of an emergency and help coordinate response for non-emergency service organizations • Design and implement emergency preparedness training to ensure that personnel respond to emergency situations in a proactive manner • Determine goals and develop comprehensive tracking systems to ensure appropriate implementation of emergency preparedness programs