Sentences with phrase «responses under other conditions»

While our data suggest cytokines may be sufficient to activate the innate - like T cells under some conditions, this does not exclude a role for TCR stimulation in promoting activation or augmenting responses under other conditions.

Not exact matches

Actual results, including with respect to our targets and prospects, could differ materially due to a number of factors, including the risk that we may not obtain sufficient orders to achieve our targeted revenues; price competition in key markets; the risk that we or our channel partners are not able to develop and expand customer bases and accurately anticipate demand from end customers, which can result in increased inventory and reduced orders as we experience wide fluctuations in supply and demand; the risk that our commercial Lighting Products results will continue to suffer if new issues arise regarding issues related to product quality for this business; the risk that we may experience production difficulties that preclude us from shipping sufficient quantities to meet customer orders or that result in higher production costs and lower margins; our ability to lower costs; the risk that our results will suffer if we are unable to balance fluctuations in customer demand and capacity, including bringing on additional capacity on a timely basis to meet customer demand; the risk that longer manufacturing lead times may cause customers to fulfill their orders with a competitor's products instead; the risk that the economic and political uncertainty caused by the proposed tariffs by the United States on Chinese goods, and any corresponding Chinese tariffs in response, may negatively impact demand for our products; product mix; risks associated with the ramp - up of production of our new products, and our entry into new business channels different from those in which we have historically operated; the risk that customers do not maintain their favorable perception of our brand and products, resulting in lower demand for our products; the risk that our products fail to perform or fail to meet customer requirements or expectations, resulting in significant additional costs, including costs associated with warranty returns or the potential recall of our products; ongoing uncertainty in global economic conditions, infrastructure development or customer demand that could negatively affect product demand, collectability of receivables and other related matters as consumers and businesses may defer purchases or payments, or default on payments; risks resulting from the concentration of our business among few customers, including the risk that customers may reduce or cancel orders or fail to honor purchase commitments; the risk that we are not able to enter into acceptable contractual arrangements with the significant customers of the acquired Infineon RF Power business or otherwise not fully realize anticipated benefits of the transaction; the risk that retail customers may alter promotional pricing, increase promotion of a competitor's products over our products or reduce their inventory levels, all of which could negatively affect product demand; the risk that our investments may experience periods of significant stock price volatility causing us to recognize fair value losses on our investment; the risk posed by managing an increasingly complex supply chain that has the ability to supply a sufficient quantity of raw materials, subsystems and finished products with the required specifications and quality; the risk we may be required to record a significant charge to earnings if our goodwill or amortizable assets become impaired; risks relating to confidential information theft or misuse, including through cyber-attacks or cyber intrusion; our ability to complete development and commercialization of products under development, such as our pipeline of Wolfspeed products, improved LED chips, LED components, and LED lighting products risks related to our multi-year warranty periods for LED lighting products; risks associated with acquisitions, divestitures, joint ventures or investments generally; the rapid development of new technology and competing products that may impair demand or render our products obsolete; the potential lack of customer acceptance for our products; risks associated with ongoing litigation; and other factors discussed in our filings with the Securities and Exchange Commission (SEC), including our report on Form 10 - K for the fiscal year ended June 25, 2017, and subsequent reports filed with the SEC.

Under normal conditions, T - cells and other immune cells collaborate to mount an immune response to invading mycobacteria, ultimately controlling their growth.

Moreover, large - scale screens in the C. elegans DMD model allowed identifying genetic and pharmacologic suppressors of dystrophin - dependent muscle degeneration; some of them positively impact mitochondrial functions or structure under stress conditions, or are involved in signaling pathways linked to mitochondria, and others are associated to proteostasis pathways such as autophagy, proteasome and Unfolded Protein Response (UPR).

At certain times and under certain conditions, some dinoflagellate species and other algal species can undergo population explosions called blooms, sometimes in response to human - caused pollution.

With BAIT, Melov and other Buck faculty are building a resource for tracking how mice age, both in response to drug treatment and under normal physiological conditions.

When I told them that this may not be the case under the design conditions of earth quakes or floods, the response was: «If that happens, people will have other things on their minds».

The causal case is a cumulative case of: 1) correlation + 2) well - evidenced mechanism (i.e. plausibility) + 3) primacy, where the proposed cause occurs before the effect + 4) robustness of the correlation under multiple tests / conditions + 5) experimental evidence that adding the cause subsequently results in the effect + 6) exclusion of other likely causes (see point 7 as well) + 7) specificity, where the effect having hallmarks of the cause (ex: the observed tropospheric warming and stratopsheric cooling, is a hallmark of greenhouse - gas - induced warming, not warming from solar forcing) 8) a physical gradient (or a dose - response), where more of the cause produces a larger effect, or more of the cause is more likely to produce the effect +....

The other study, published in 2016 by the U.S. - based National Academies of Sciences on the «environmental fate, effects and responses» of diluted - bitumen spills from pipelines, also cited the need for further study to address «diluted bitumen's behaviour in the environment under different conditions, its detection when submerged or sunken, and the best response strategies for mitigating the impacts of submerged and sunken oil.»

Response: We do not believe this will be a problem under the final regulation, because we create an exception to the right to revoke an authorization if the authorization was obtained as a condition of obtaining insurance coverage and other applicable law provides the insurer that obtained the authorization with the right to contest a claim under the policy.