Sentences with phrase «restore normal gene»

«Once we identify that disruption, we can begin exploring ways to restore normal gene function during early heart formation — and reduce the number of babies born with debilitating, and sometimes fatal, congenital heart defects.»

Not exact matches

This question has been challenging to address experimentally because attempts to restore function to lost or mutated genes in cancer cells often trigger excess gene activity, causing other problems in normal cells.

However, cancer cells may instead be coaxed to turn back into normal tissue simply by reactivating a single gene, according to a study that found that restoring normal levels of a human colorectal cancer gene in mice stopped tumor growth and re-established normal intestinal function within only 4 days.

The scientists are now screening for drugs that restore the gene network to its normal state.

In an independent effort, they introduced progressively smaller pieces of DNA from the large region known to contain the gene into embryos of the mutant mice, looking for the smallest piece that would correct the mutation in adult mice and restore a normal rhythm.

The aim now is to identify the molecules that regulate expression of this gene upstream, and those that interact with the enzyme, to understand their modes of action and determine how normal MOCOS expression could be restored..

If a mutated gene causes damage to or spurs the disappearance of a necessary protein, for example, gene therapy may be able to introduce a normal copy of the gene to restore the function of that protein.

«We hope that in the future, by fully understanding how this gene affects signaling in the brain, we may be able to identify drugs to restore the normal signaling balance in neurons and improve cognitive and social function in patients,» says lead author Dr. M. Chiara Manzini.

In April 2000, pediatric immunologist Alain Fischer at Necker Hospital in Paris announced that he and his team had successfully installed a gene that restores normal immune function in three baby boys with a rare genetic illness.

Supplementing B vitamins into the insect's diet or reestablishing the symbiotic partnership restores normal expression patterns of those genes.

Cook and his colleagues were even able to restore some normal walking ability to stum - mutant flies by adding the mouse version of the stum gene.

A drug called Repoxygen delivers the EPO gene with some controls, so that when blood oxygen dips below normal, the body makes enough red blood cells to restore normal oxygen.

«This tells us that vitamin A can enter at some point in the pathway and restore normal expression of the genes such as lefty1 involved in the process,» said Izpisúa Belmonte.

In the study, functional Ikaros protein produced from the one remaining normal Ikaros gene was restored with a novel class of drugs that target a specific enzyme called casein kinase 2 or CK2.