«The effect of the precursors that boost NAD is to counteract the decline that occurs with normal aging, to reactivate SIRT1, and to
restore function in
endothelial cells to give rise to more blood vessels.»
Inhibition of myeloperoxidase or NADP (H) oxidase partially
restored normal nitric oxide bioavailability and
endothelial function, which suggests a role of activation of these endogenous radical - generating enzymes in this biological response.363