Sentences with phrase «result in diseases»

The judge held that, while the evidence was not uniform, it still led him to the conclusion that the occupation of a baker or confectioner was unhealthy, and tended to result in diseases of the respiratory organs.

Fleas and ticks can be seen by examining a puppy's skin and can cause frequent itching and biting, loss of hair, and result in diseases.

In the suppurative form (called Suppurative Cholangitis or Cholangiohepatitis) bacterial, fungal or protozoal infection of the liver's system of ducts that transport bile result in the diseases.

Many of these mutations are harmless, but others can result in diseases like cancer.

Some of these mutations are completely harmless, but others are thought to result in diseases such as cancer and even arthritis.

The use of higher resolution techniques, such as array CGH and, soon, whole genome sequencing, will enhance the ability of researchers to examine stem cell lines to determine which are best — least likely to result in diseases and other problems — to use in creating therapies for use in humans.

«It has profound implications for our understanding of human development and physiology, and gives us a remarkable wealth of resources to examine how disturbances of this system might result in diseases such as cancer.»

For unknown reasons our immune system attacks healthy cells, tissues and organs in a process called autoimmunity, which can result in diseases such as multiple sclerosis, type 1 diabetes, lupus or rheumatoid arthritis.

Oh but alcohol is fine and yet the use of it results in disease and numerous deaths each year whereas use of marijuana has been attributed to no death or disease.

In the study, exosomes, which are generated by all cells and are naturally present in blood, were modified as «iExosomes,» capable of delivering small RNA to specifically target mutant KRAS, resulting in disease suppression and increased overall survival in mouse models.

Though the UPR usually promotes healthy endoplasmic reticulum function, sustained UPR activation sometimes results in diseases such as atherosclerosis, the deposition of fatty plaques on artery walls, among other conditions.

Xia's disease - relevant findings again illustrate the importance of «basic» research, said OMRF Vice President of Research Paul Kincade, Ph.D. «Researchers had to first understand how the protective mucous layer is put together before they could learn how that results in disease.

«When sequencing DNA, we are looking for the high priority variants, or genetic mutations that result in disease.

We need to go back to the earliest events that trigger the chain reaction that ultimately results in disease so we can focus new therapies on the cause, not the consequences.»

CNVs are structural alterations to the DNA of a genome that can be present as deletions, additions, or as reorganized parts of the gene that can result in disease.

Knowing that many inactivated genes don't result in disease will also be important when sequencing genomes becomes routine in the clinic, MacArthur says.

In people who subsist on a diet of mostly corn, that niacin deficiency can result in a disease called pellagra.

The problem is when the error can't be rectified and the mutation results in a disease.

Because of the single mutation in GATA4, virtually the entire network of genes regulated by GATA4 and TBX5 were disrupted, resulting in disease.

A variety of different mutations in the Immunoglobulin mu - binding protein 2 (Ighmbp2) gene have been identified to be the cause of SMARD, but the mechanism of how these mutations result in this disease are still unknown.

Dr. Srivastava showed that when cells in the heart get confused about their fate it can result in disease, like when cells in the valve start behaving like bone cells and deposit calcium — a leading cause of heart disease.

Human infection with the etiologic agent of Lyme disease, Borrelia burgdorferi, results in disease of a few hallmark clinical signs and multifarious symptoms.

Using mouse models of MS, Dr. Akassoglou has shown that higher levels of these proteins are early indicators of MS and key contributors to neuron damage, resulting in disease progression.

Understanding how our exposures from our environment, diet and lifestyle, etc. interact with our own unique characteristics like genetics, physiology and epigenetic makeup, resulting in disease, is how the exposome will be deciphered [26].

As a result, they contain a complete set of the genes that resulted in that disease — representing the potential of an almost perfect disease model for studying disease development, new drugs and treatments.

«We've known for a while that mutations in TBX5 result in different types of heart disease, but how these mutations result in disease has largely remained a mystery,» said Bruneau, who is the associate director of the Gladstone Institute of Cardiovascular Disease.

But when free circulation is restricted, it can result in disease.

Deficiency of B3 or niacin results in the disease pellagra, characterized by dermatitis, dementia, tremors and diarrhea.

The combination of their traditional way of eating and the introduction of refined carbohydrates usually results in disease, tooth decay, and obesity.

Jaundice often results in disease of liver like liver cancer and hepatitis.

The exposure encountered could occur every day while in the school, it may occur for many years resulting in a cumulative exposure which could potentially result in a disease developing in years to come.

Research has been ongoing at the Mayo Clinic with treatment for patients with neurological disorders that result in disease (e.g. Parkinson's) or in physical impairments such as epilepsy and disorder dyspraxia.

Many years of poor diet and exposure to chemicals may result in disease in old age.

Therefore, it is possible that a defective gene may lead to a malformed or absent protein resulting in disease.

It can take a long time for adverse conditions to result in disease or health problems.

With an autosomal dominant disease, if one of the pair of genes is abnormal, this is «dominant» over the normal gene, and results in disease development.

Spores from the soil must be inhaled to result in disease.

According to the Ryan Veterinary Hospital of the University of Pennsylvania, «Periodontal disease is the most common disease seen in companion animals, which, when left untreated, may result in disease elsewhere in the body.

By stealing electrons from particles inside of DNA, they cause mutations that can result in disease.

Sometimes, though, free radical activity results in mutations that can result in disease.

Some of these cells simply die, while others develop mutations that eventually result in disease.

PRA in the Cardigan Welsh corgi, termed rod - cone dysplasia 3 (RCD3), is also caused by a mutation in a subunit of cGMP phosphodiesterase, this time the alpha subunit, which results in a disease with a comparable age of onset to RCD1 [4].

If allowed to remain on the tooth surface, tartar and calculus eventually erode the overlying gums and, in severe cases, erosion of the tooth roots and bone surrounding tooth roots occurs (called periodontal disease), resulting in a diseased tooth in need of extraction.

Other causes of PRA can be other mutations, other genes, or non-genetic factors that result in a disease that looks similar on eye exam.

Plaque harbors the bacteria that can infect gum tissue and the roots of teeth, which results in disease and tooth loss.

Acupressure for dogs is aimed to correct imbalances in the dog's qi, which according to its practitioners, can result in disease or sickness.

«At a cellular and metabolic level and in very simple terms, obesity puts a strain on the system, which may result in disease.

It is bad news to learn from our leading authorities that 99 percent of the American people are deficient in these minerals, and that a marked deficiency in any one of the more important minerals actually results in disease.

Therefore, if you sustained a dog bite that resulted in a disease transmittal, the owner is responsible for the disease transmission.

Not exact matches

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.