Sentences with phrase «result of a single gene»

Not exact matches

Even though there's no single «morning person gene» the results indicate that your love of the snooze button isn't entirely down to laziness, personal choice or your environment.

The disease results from a single mutation in the gene that codes for one of the protein chains that make up the hemoglobin molecule.

With a single local injection of the USH1G gene just after birth, the scientists observed a restoration of the structure and mechanosensory function of the inner ear hair bundles — profoundly damaged before birth -, resulting in a long - term partial recovery of hearing, and complete recovery of vestibular function in these mice.

Patients with Parkinson's disease may be the first group to benefit from gene therapy, the much hyped technique that has yet to result in a single reliable treatment despite nearly two decades of experimentation.

The results of the study were obtained by infecting laboratory - grown cells with forms of the CMV virus which differed only by the removal of a single gene.

According to study co-author Larry J. Young of Emory University, the results provide evidence in a comparatively simple animal model that changes in the activity of a single gene profoundly can change a fundamental social behavior of animals within a species.

«To our knowledge, our model is the first in which expression of a single gene in postnatal hair cells results in hair cell survival and hearing preservation in mice that otherwise suffer from age - related and noise - induced hearing loss,» Dr. Chen said.

Results from a statistical analysis shows a cluster of SNPs — single nucleotide polymorphisms — in one section of a single gene, indicating the location of a mutation likely linked to autism.

«We report here a gene therapy dose - finding study in a large animal model of a severe muscle disease where a single treatment resulted in dramatic rescue,» said Childers.

Domain recombination resulted in greater diversity in pathway response dynamics than did duplication of genes, of single domains, or of two unlinked domains.

As a result, researchers have tended to focus on point variations, such as the mutation or deletion of a single DNA letter within a gene.

Hereditary predisposition to cancer is sometimes due to a single high - risk genetic change, like a mutation in the BRCA1 or BRCA2 genes for breast cancer, but most of the time, the disease is the result of multiple gene variants that add up, environmental risk factors, and a big element of chance.

Gene moonlighting can occur merely through changes in expression, which may result from as little as a single mutation; it does not require the meandering process of random alteration and selection implied by the duplication and neofunctionalization model.

Since a single disorder might result from hundreds of different gene combinations, it's unlikely that researchers will find one drug that tackles all of them.

Through the combination of linkage data and exome sequencing, they have identified a deletion or loss of a single base in the gene encoding STAG3, which results in a prematurely truncated protein without function.

The university recently received international attention after a group of 16 scientists based at the Key Laboratory of Gene Engineering published the results of a controversial experiment in which they genetically modified single - cell human embryos to repair the human β - globin (HBB) gene in a procedure aimed at preventing a serious blood disorder (www.sciencemag.org/content/348/6234/486.fuGene Engineering published the results of a controversial experiment in which they genetically modified single - cell human embryos to repair the human β - globin (HBB) gene in a procedure aimed at preventing a serious blood disorder (www.sciencemag.org/content/348/6234/486.fugene in a procedure aimed at preventing a serious blood disorder (www.sciencemag.org/content/348/6234/486.full).

The end result, Bier says, is that both copies of a gene could be inactivated «in a single shot.»

The results also showed that polymorphism, a genetic variant that can change the way a particular gene functions, is possible under a wide range of conditions, which results in a single population playing a variety of different behavioral games.

Cardiomyopathy can be caused by a single mutation in any one of a number of genes, each one resulting in a slightly different variant of the disease.

Because of the single mutation in GATA4, virtually the entire network of genes regulated by GATA4 and TBX5 were disrupted, resulting in disease.

Paris, France, April 3, 2018, 5.35 pm CET — GenSight Biologics (Euronext: SIGHT, ISIN: FR0013183985, PEA - PME eligible), a biopharma company focused on discovering and developing innovative gene therapies for retinal neurodegenerative diseases and central nervous system disorders, today announced topline results from the REVERSE Phase III clinical trial evaluating the safety and efficacy of a single intravitreal injection of GS010 (rAAV2 / 2 - ND 4) in 37 subjects whose visual loss due to 11778 - ND4 Leber Hereditary Optic Neuropathy (LHON) commenced between 6 and 12 months prior to study treatment.

In contrast to Mendelian disorders (e.g., Huntington's disease, sickle cell anemia) in which variation in a single gene causes disease, common complex disorders, such as heart disease, diabetes, and most cancers, develop as a result of both genetic and environmental factors.

Out of a total of five positively selected SNPs, four represented nonsense mutations resulting in stop codons, three of these in a single ApiAP2 transcription factor gene, and one in SRPK1.

Similar results are observed in DE analyses of real data where the use of count sums instead of single - cell counts improves specificity and the ranking of relevant genes.

Results: We confirmed the Gallus Gallus v5 consensus except for two insertions of 5 and 1 base pair within the chIFITM3 and B4GALNT4 genes, respectively, and a single base pair deletion within the B4GALNT4 gene.

Take cystic fibrosis, a genetic disease that creates a life - threatening accumulation of mucus in the lungs and is known to result from a single mutation in a single gene.

Less than 2 % of diseases, such as cystic fibrosis, Huntington's chorea, and beta thalassemia, result from a single faulty gene, and only about 5 % of cancer patients can attribute their diseases to heredity.

It is, therefore, no surprise that a number of genetic studies have been performed in this breed, with results proposing a single major gene with a large effect on seizures 8, 24 - 26.

This means that it is not associated with the sex chromosomes, but simply determined by a single gene that one parent can pass to an offspring, the result having varying degrees of severity.

For single - gene DNA tests to be fully effective in reducing or eliminating inherited disorders, the tests must not be based on any preliminary or assumed relationship, and we must understand the full biology between susceptibility and resulting development of disease.