Sentences with phrase «resulting gene copies»

As the authors note, «the presence of duplicated and diverged genomic regions probably promotes functional novelty between resulting gene copies, following positive selection.»

Not exact matches

They made these clones by a process called automatic parthenogenesis: The egg is formed normally (with half the species» usual number of chromosomes), then fertilized by the «polar body,» a cell that is created during oogenesis and contains the same gene copies as the egg, resulting in the shark having half the genetic variation of its mother.

The result is that individuals with the most common form of the disease have a total of three copies of all the genes in this region.

Ovarian cancer cells use autophagy all of the time, but also lose several copies of autophagy genes resulting in a compromised capacity.

A team of 18 University of California San Diego School of Medicine and Moores Cancer Center researchers has developed a new tool to analyze an often overlooked aspect of cancer genetics — an alteration that results in the loss or gain in a copy of a gene.

Angelman syndrome, which causes learning difficulties, speech problems, seizures, jerky movements and an unusually happy disposition, results when a gene inherited from the mother in a particular area of chromosome 15 is mutated and the other copy of the gene, inherited from the father, is silenced.

While the increase in EPSPS gene copies has created a nonsustainable way of controlling kochia with glyphosate - only programs, Jugulam said this resistance was evolved as the result of continuous use of glyphosate and the lack of herbicide diversity in controlling this weed.

Those results are the same if the enhancers are intact but both copies of the gene itself are defective, indicating that the amount of protein determines the number of digits.

Results from the analysis confirmed previous findings of some copy number variants already associated with autism, but they also found a host of other genes (SHANK2, SYNGAP1, DLGAP2 and the X chromosome — linked DDX53 - PTCHD1 locus) in which mutations seem to be linked to autism.

Apparently as a result, the 13 people they studied end up heavier and packed with a significantly higher percentage of body fat than family members with two normal copies of the leptin gene, the team reports in the 1 November issue of Nature.

The deletion of one copy of the gene resulted in substantial improvements in most symptoms, while deleting both copies eliminated them almost completely.

If one copy of the SLC2A1 gene is completely dysfunctional, the results are devastating: The brain develops to only a portion of its normal size.

This mutated gene copy was also duplicated in the cancer genome, resulting in elevated expression.

The researchers analyzed the genomes of all four children and found that each had two mutated copies of the CD70 gene, resulting in nonfunctioning or nonexistent CD70 proteins.

The end result, Bier says, is that both copies of a gene could be inactivated «in a single shot.»

When daughter viruses assemble themselves in the cytoplasmic soup of genes and proteins, the overall virus that results is often a mash - up of these mutated copies.

«According to these simple rules of inheritance, the fertilized egg receives one copy of most genes from our mothers and one from our fathers so that the resulting individual has two copies of each gene.»

Adding an extra copy of the azot gene to increase levels of the azot protein results in more effective destruction of less fit cells, and an increase in life span - in fruit flies at least.

As a result, the child gets two active copies of the gene.

As a result, virtually everyone with Williams syndrome has exactly the same set of genes missing (25 to 28 genes are missing from one of two copies of chromosome 7).

They showed that removal of the tails resulted in the retention of 1.4 to 7.8 times higher number of copies in four out of five colon - specific genes expressed at low levels after subtraction.

To identify additional alterations, the investigators looked at DNA copy number changes, or changes in gene number resulting from the deletion or amplification (multiplication) of sections of DNA in the genome.

About 90 % of solid tumors display whole - chromosome aneuploidy, while many tumors with diploid karyotypes nonetheless harbor segmental or arm - length aneuploidies that also result in significant gene copy number alterations.

For 1,317 distinct genes, both copies were found to have deleterious mutations in at least one individual, resulting in «human knockouts» for a remarkable number of new genes for whom human knockouts have never been reported.

Our results establish gene conversion as a previously under - appreciated mechanism of generating copy number changes in humans and reveal the exceptionally large size of the conversion events that can occur.

The result: an embryo with two healthy copies of the gene that, if implanted in a woman and allowed to gestate, should result in a baby free from risk of hereditary cardiomyopathy.

The result was that Xist modified the extra copy so as to deactivate most of its genes and the protein production associated with Down's.

Merle issues Breeding two merles together will lead to two copies of the merle gene being present in the pups resulting in eye, ear and abdominal problems.

This dog carries two copies of ky which allows for the expression of the agouti gene (A locus) which can result in a variety of coat colors including sable / fawn, tricolor, tan points, black or brown.

Results will indicate whether your dog has one, two, or no copies of the mutated version of the PRCD gene.

DNA test results will indicate if the cat has the mutation on 1 copy of its 2 gene copies (called heterozygous) or both gene copies (homozygous).

If a working copy of the gene is present in a domestic cat, it will result in the narrow striped mackerel pattern; if the gene is turned off by a mutation, the cat will display the traditional blotchy or marbled tabby pattern.

When two carriers are mated, some of the puppies receive one copy of the affected gene from each parent, resulting in an affected puppies.

Puppies with two copies of the PSMB7 gene variant (H / H) most likely die very early in gestation; therefore, breeding two dogs with harlequin coat color (H / h) may result in reduced litter size.

Genetic test results for the mutation will be normal, carrier (one copy of the mutated gene), or affected (two copies of the mutated gene).

As a result, these dogs are capable of producing the condition if mated with another OES that contributes a second copy of the recessive gene.