Sentences with phrase «resulting mice in their study»

Not exact matches

They've conducted studies in mice, which showed that the device was able to improve the results of the drug by twelve times.

While study results indicated that combining capsaicin with the chemicals «might promote cancer cell survival,» the report clearly stated that the control group of mice treated only with capsaicin ``... did not induce any skin tumors...» In addition, the study repeatedly cited other research studies in which the anti-cancer properties of capsaicin were solidly demonstrateIn addition, the study repeatedly cited other research studies in which the anti-cancer properties of capsaicin were solidly demonstratein which the anti-cancer properties of capsaicin were solidly demonstrated.

More work has to be done on humans as many of the results showed up in mice samples, however in studying the human brains of women who had AD scientists found significantly less male fetal tissue in their brains as in the same of women who did not have AD.

Depending on results from further behavioural studies in mice and humans, the abnormalities could then be treated in parallel with seizures.

«Our studies provide promising results in mice, which merit further investigation, such as adjusting the formulation, dose and delivery route of MAOA inhibitors, prior to ultimate clinical application.»

The clinical trial in humans was based on positive results of a study in mice published in Nature Communications in Sept. 2015.

The study results were found using mouse embryonic stem cells, which are good cell models for the study of processes seen in human stem cells.

In the study, published online today by Science Translational Medicine, researchers removed breast tumors from mice and placed biodegradable gels containing an immune - stimulating drug in the resulting empty spacIn the study, published online today by Science Translational Medicine, researchers removed breast tumors from mice and placed biodegradable gels containing an immune - stimulating drug in the resulting empty spacin the resulting empty space.

The results of his study done on cells and mice were published this month in the journal Diabetes.

The study «provided the surprising result that one new therapy currently being explored to lower insulin resistance promotes, rather than decreases, the formation of bone in mice,» says Darwin Prockop, a stem cell researcher at Texas A&M College of Medicine in Temple, who was not involved in the work.

Results from the UCLA study showed a complete eradication leukemia in mice.

Managing the microbiome instead of pummeling it with antibiotics has produced impressive results in chicken and mice studies, pointing the way not just to future human treatments but also to a healthier food supply.

In the study, exosomes, which are generated by all cells and are naturally present in blood, were modified as «iExosomes,» capable of delivering small RNA to specifically target mutant KRAS, resulting in disease suppression and increased overall survival in mouse modelIn the study, exosomes, which are generated by all cells and are naturally present in blood, were modified as «iExosomes,» capable of delivering small RNA to specifically target mutant KRAS, resulting in disease suppression and increased overall survival in mouse modelin blood, were modified as «iExosomes,» capable of delivering small RNA to specifically target mutant KRAS, resulting in disease suppression and increased overall survival in mouse modelin disease suppression and increased overall survival in mouse modelin mouse models.

But studies in mice have shown that mixtures of mitochondria can result in neurological disorders or metabolic conditions.

In their study, Stephanie Cherqui, PhD, associate professor in the UC San Diego School of Medicine Department of Pediatrics, and colleagues used a transgenic mouse model that expresses two mutant human FXN transgenes, and exhibits the resulting progressive neurological degeneration and muscle weaknesIn their study, Stephanie Cherqui, PhD, associate professor in the UC San Diego School of Medicine Department of Pediatrics, and colleagues used a transgenic mouse model that expresses two mutant human FXN transgenes, and exhibits the resulting progressive neurological degeneration and muscle weaknesin the UC San Diego School of Medicine Department of Pediatrics, and colleagues used a transgenic mouse model that expresses two mutant human FXN transgenes, and exhibits the resulting progressive neurological degeneration and muscle weakness.

Preliminary results from his latest mouse studies show that an herb used in traditional Chinese medicine supplies a microRNA that combats the flu virus in the lungs.

HUR K Junho, first author of the study said, «The data showed that Cpf1 RNP's delivery to mouse embryos resulted in knocking out the intended genetic functions with high mutation frequencies, 64 % and 33 % respectively.

Gould and Georgiou say that their results don't necessarily invalidate previous studies; they simply show that ketamine experiments in their lab work only when men inject the mice.

In 1999 scientists published spectacular results from a study in which a vaccine cured the mouse equivalent of Alzheimer'In 1999 scientists published spectacular results from a study in which a vaccine cured the mouse equivalent of Alzheimer'in which a vaccine cured the mouse equivalent of Alzheimer's.

Research in recent years has covered both preclinical basic research and the transfer of the results generated from studies of mouse models to clinically applicable techniques for treating female infertility.

The results build on a wave of studies in the last decade in which investigators sewed together the skins of two mice, joining their circulation systems, and studied the effects on various tissues.

«What we saw in mice lacking STIM1 — whose T - cells can not generate calcium signals — is that the number of mycobacteria in their lungs was dramatically increased, resulting in excessive inflammation,» says Stefan Feske, MD, an associate professor of pathology at NYU Langone and the study's senior author.

Previous proteomic studies in humans with brain injuries didn't control for the cause, while results in mice examined the effects of time since injury or repeated injury, but not both.

Researchers studying caloric restriction in mice have become accustomed to mixed results, which they attribute to genetic diversity among strains.

The causes of such unpredictable results, Harris said, can include bad ingredients in the lab, including contaminated and misidentified cell lines; poor research design, including insufficient numbers of mice in animal studies; statistical error and overreach, including «HARKing» (hypothesizing after the results are known), a push beyond the limits of the data; and funding pressures, which can lead scientists to hype or exaggerate their results to remain competitive for additional grant money.

«However, because our study was conducted in mice, this idea needs to be rigorously tested in humans to see if the results would be applicable to people.»

The study was conducted on mice, and the results will be published in the February issue of Journal of Nutritional Biochemistry.

To show why, he pulls out a raft of study results collected in a large three - ring binder and points to several studies showing that mice subjected to stress developed more cancers than normal mice.

Combined with rapamycin, metformin (teal) boosted median life span in both sexes about 23 percent, but the result wasn't statistically different from life span boosts in mice given rapamycin alone in previous studies.

Studies are needed to see its effects on ALS in humans, but our preliminary results in mice are very promising.»

The results of the mouse, human and lab studies have been so successful that Dr. Bauman has started a larger clinical trial in volunteers previously cured of head and neck cancer.

In this study, the researchers found that macrophages from mice lacking Smurf1 were unable to attach the death - tagging protein ubiquitin to intracellular bacteria, resulting in a failure of the autophagy pathway and runaway growth of the bacteria inside the cellIn this study, the researchers found that macrophages from mice lacking Smurf1 were unable to attach the death - tagging protein ubiquitin to intracellular bacteria, resulting in a failure of the autophagy pathway and runaway growth of the bacteria inside the cellin a failure of the autophagy pathway and runaway growth of the bacteria inside the cells.

Results of previous studies in mice of bexarotene's effect on AD have been mixed, and none of those studies were done in mice that carry a human APOE gene and also develop progressive, AD - like pathology.

The most interesting thing about the results, she says, was not the correction of the autistic symptoms in the mice, but the clues the study provided about how the gut's microbial population may affect the brain and behavior.

A new study in The American Journal of Pathology reports that mice fed a Western diet, which is high in fat and sugar, resulted in hepatic inflammation, especially in males.

Animal studies have also found that a stress to a parent, such as exposing a pregnant mouse to toxic chemicals or mildly shocking a mouse father to make it fear an odor, can result in effects such as infertility or changes in behavior that persist for two generations or more yet can't be explained by genetic mutations.

After introducing stem cells in brain tissue in the laboratory and seeing promising results, Prof. Offen leveraged the study to mice with Alzheimer's disease - like symptoms.

While the research reported in this paper manipulated pluripotent mouse cells, the researchers have moved ahead in performing similar studies with human stem cells and achieved comparable types of results with the microparticle delivery approaches.

The drug has shown positive results in recent studies of mouse models of these diseases.

Crystal hopes to improve on his team's results by using a different type of viral vector that worked much better in mice in his latest studies.

In previous studies, we showed that the increase in muscle mass in Mstn − / − mice results from a combination of increased fiber numbers and increased fiber sizes [2In previous studies, we showed that the increase in muscle mass in Mstn − / − mice results from a combination of increased fiber numbers and increased fiber sizes [2in muscle mass in Mstn − / − mice results from a combination of increased fiber numbers and increased fiber sizes [2in Mstn − / − mice results from a combination of increased fiber numbers and increased fiber sizes [2].

«The research provides the first evidence that, as early as 15,000 years ago, humans were living in one place long enough to impact local animal communities — resulting in the dominant presence of house mice,» said Fiona Marshall, study co-author and a professor of anthropology at Washington University in St. Louis.

However, studying Zika in mice with compromised immune systems could skew results.

Because one small study suggested that a professional integrated pest management (IPM) intervention could result in large reductions in home mouse allergen levels, the researchers wanted to know whether professional IPM reduced asthma morbidity in asthmatic children who are known to be allergic to mice and also regularly exposed to mouse allergens at home.

This result implies that only large treatment effects can be detected by efficacy studies in hAPP mice, since the number of mice per group will likely not be greater than 50, for practical and ethical reasons.

Of the 22 patients whose tumors successfully grafted, six died before data from the mice were available, but in 13 of the remaining 16 cases, there was a positive correlation between mouse and human results.2 In a second study, performed in collaboration with Manuel Hidalgo of the Spanish National Cancer Research Center, the team found that 6 of 13 patients with advanced solid tumors who were treated based on results from personalized PDX mice had partial tumor remissions, even in cases where genetic sequencing of the tumor showed no actionable mutationsin 13 of the remaining 16 cases, there was a positive correlation between mouse and human results.2 In a second study, performed in collaboration with Manuel Hidalgo of the Spanish National Cancer Research Center, the team found that 6 of 13 patients with advanced solid tumors who were treated based on results from personalized PDX mice had partial tumor remissions, even in cases where genetic sequencing of the tumor showed no actionable mutationsIn a second study, performed in collaboration with Manuel Hidalgo of the Spanish National Cancer Research Center, the team found that 6 of 13 patients with advanced solid tumors who were treated based on results from personalized PDX mice had partial tumor remissions, even in cases where genetic sequencing of the tumor showed no actionable mutationsin collaboration with Manuel Hidalgo of the Spanish National Cancer Research Center, the team found that 6 of 13 patients with advanced solid tumors who were treated based on results from personalized PDX mice had partial tumor remissions, even in cases where genetic sequencing of the tumor showed no actionable mutationsin cases where genetic sequencing of the tumor showed no actionable mutations.3

«These results in mice are promising,» said Beth Kozel, MD, PhD, the senior author for the study.

The results of long - term safety studies in mice were previously submitted to the Food and Drug Administration to gain permission for a Phase 1 clinical trial under an Investigational New Drug (IND) application.

Catalase: Gene therapy to increase levels of the antioxidant catalase in the mitochondria in mice have produced mixed results, but some studies show improved health and extended life.

In the latest edition of EBioMedicine, Bo Wang, doctoral student in the WSU Department of Animal Sciences, detailed results of his four - year study of the effects of prenatal vitamin A in micIn the latest edition of EBioMedicine, Bo Wang, doctoral student in the WSU Department of Animal Sciences, detailed results of his four - year study of the effects of prenatal vitamin A in micin the WSU Department of Animal Sciences, detailed results of his four - year study of the effects of prenatal vitamin A in micin mice.