Results of a new trial of treatments for chronic whiplash pain, published in The Lancet, suggest that expensive, intense physiotherapy sessions do not show any additional benefit over a single physiotherapy session of education and advice with phone follow - up.
The scanners will not be installed in Terminals 1 and 3 as originally announced, until
the results of the new trial in T2 are ascertained.
Not exact matches
While the
new mid-stage study
results from DNDi were impressive (they showed cure rates
of 96 % to 97 % even for the sickest patients and those with liver scarring), more late - stage
trials will be necessary before the drug is available on a large scale in the developing world.
In particular, the complaint alleges that throughout the Class Period, defendants made materially false and / or misleading statements and / or failed to disclose that (1) the
trials for GED - 0301 suffered from fatal design defects, such that GED - 0301 had failed to demonstrate meaningful clinical efficacy; (2) the growth
of Otezla sales had dramatically slowed during Celgene's third fiscal quarter
of 2017; and (3) the clinical and nonclinical pharmacology data in Celgene's
new drug application («NDA») for Ozanimod were insufficient to permit a complete review by the FDA, which
resulted in the FDA issuing a refusal to file letter to Celgene regarding the NDA.
And we settled the case, because no one wanted a three - year appeal that would
result in a
new trial four to five years from the date
of the current
trial.
Cologuard was approved by the FDA in August 2014 and
results from Exact Sciences» prospective 90 - site, point - in - time, 10,000 - patient pivotal
trial were published in the
New England Journal
of Medicine in March 2014.
These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial
results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for
new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount
of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability
of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction
of generic versions
of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect
of lowering prices or reducing the number
of insured patients; the possibility
of unfavorable
results from clinical
trials involving investigational compounds; Gilead's ability to initiate clinical
trials in its currently anticipated timeframes; the levels
of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits
of the Sangamo partnership; Gilead's ability to submit
new drug applications for
new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for
new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages
of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development
of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate
of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).
Since 2008, Good Cookies like YOU have helped fund dozens
of pediatric cancer research grants,
resulting in NINE promising
new treatments moving to clinical
trial, now available to children with cancer.
As a
result of the successful
trial, a
new IX - GA - 4057 X-ray system has been permanently installed on Anatolia's bulk packaging line and carries out a final product inspection — removing any foreign bodies which have «slipped» through the upstream inspection process.
«The
results of this [
new]
trial are so compelling, and the problem
of the increasing prevalence
of peanut allergy so alarming.»
Labour suggested the
new guidelines were a
result of concerns over the Twitter joke
trial, in which a man was prosecuted or jokingly threatening to blow up an airport - a decision Starmer supported.
He was a supervising agent in the
New York investigation
of the Cosa Nostra criminal network that
resulted in the Mafia Commission
Trial of 1985 — 1986.
New court precedent has impacted the cases of New York lawmakers before: precedent set by the U.S. Court of Appeals for the Second Circuit eventually resulted in a new trial being ordered for Skelos» predecessor in the Senate, Joseph Bru
New court precedent has impacted the cases
of New York lawmakers before: precedent set by the U.S. Court of Appeals for the Second Circuit eventually resulted in a new trial being ordered for Skelos» predecessor in the Senate, Joseph Bru
New York lawmakers before: precedent set by the U.S. Court
of Appeals for the Second Circuit eventually
resulted in a
new trial being ordered for Skelos» predecessor in the Senate, Joseph Bru
new trial being ordered for Skelos» predecessor in the Senate, Joseph Bruno.
In June, the U.S. Supreme Court overturned the corruption conviction
of former Virginia Gov. Bob McDonnell in a ruling that could
result in
new trials for Silver and Skelos.
What's being revealed at
trial of how the pay - to - play culture works in
New York, which has
resulted in a $ 30 million political war chest for the governor, is a case in point.
The
trial of Ciminelli and Laipple and others is slated to start in
New York on June 11, and its
results could be part
of this fall's election as Gov. Andrew M. Cuomo seeks re-election.
He named the challenges militating against cocoa production in the country as the unreliable supply
of inputs to farmers as a direct
result of the «free» input policy adopted by the government,
new brands
of chemical inputs released to cocoa farmers in Ghana without adequate
trials and research by designated institutions, low producer prices paid to farmers and the politicisation
of the mass spraying and fertiliser distribution programme.
Adding abiraterone to hormone therapy at the start
of treatment for prostate cancer improves survival by 37 per cent, according to the
results of one
of the largest ever clinical
trials for prostate cancer presented at the 2017 ASCO Annual Meeting in Chicago and published in the
New England Journal
of Medicine.
Results of the
trial, reported in the May 31 issue
of the
New England Journal
of Medicine and presented at the American Society for Clinical Oncology 2015 annual meeting, also showed that after a year, the nivolumab group had nearly double the survival rate (42 percent)
of the chemotherapy patients (24 percent).
A University
of Manchester led
trial of a
new psoriasis drug has
resulted in 40 percent
of people showing a complete clearance
of psoriatic plaques after 12 weeks
of treatment and over 90 percent showing improvement.
Boni E. Elewski, M.D., professor
of dermatology, is the principal investigator
of the Efficacy
of Response And Safety
of two fixed secUkinumab REgimens in psoriasis (ERASURE)
trial, one
of two studies in the recent
New England Journal
of Medicine article «Secukinumab in Plaque Psoriasis —
Results of Two Phase 3
Trials.»
Dr. Del Maestro adds, «Yong and colleagues at the University
of Calgary have begun to unravel the complex interaction
of the microglia with the brain tumor cells,
resulting not only in furthering our understanding, but providing a
new concept and drug which can now be immediately assessed in clinical
trials.»
The much - awaited
results of a large randomized
trial comparing three approaches to localized prostate cancer were published in The
New England Journal
of Medicine today.
«The
results of the phase III clinical
trial show that a target fusion biopsy detects more clinically significant prostate cancer,» said Art Rastinehad, DO, principal investigator
of the study and director
of interventonal urologic oncology at North Shore - LIJ's Arthur Smith Institute for Urology, in
New Hyde Park, NY.
«These exciting
results indicate that there is a
new standard
of care option for a population
of head and neck cancer patients with no other treatment options,» said the
trial's international co-chair Robert Ferris, M.D., Ph.D., UPMC Endowed Professor, and chief
of the Division
of Head and Neck Surgery and co-leader
of the Cancer Immunology Program at UPCI.
In a trio
of studies to be presented at the 57th American Society
of Hematology (ASH) Annual Meeting and Exposition in Orlando, investigators at Dana - Farber Cancer Institute will present the
results of clinical
trials showing that
new drug combinations can significantly extend the time in which multiple myeloma is kept in check in patients with relapsed or treatment - resistant forms
of the disease.
People diagnosed with cancer gained 3.34 million years
of life thanks to cancer clinical
trials run by SWOG and supported with public funds, according to
new study
results to be presented at the 53rd Annual Meeting
of the American Society
of Clinical Oncology (ASCO), the world's largest clinical cancer research meeting.
Promising
results from the
new trial would be a major step forward for a field that has long been criticized for studies that are poorly designed, incomplete or lack control - group comparisons, as well as for the peddling
of unproved therapies in many clinics worldwide.
The final
results from an international clinical
trial involving nearly 2,000 patients with Crohn's disease support the use
of a
new management strategy referred to as accelerated step - care as a best practice for the care
of active Crohn's disease.
The
new study helps explain why so many
results in animal studies don't hold up in human
trials, says Malcolm Macleod, a neurologist at the University
of Edinburgh.
A
new type
of cancer vaccine has yielded promising
results in an initial clinical
trial conducted at the Perelman School
of Medicine at the University
of Pennsylvania and the Abramson Cancer Center
of the University
of Pennsylvania.
The
results of the
trial have not yet been published, but the volunteers seemed to be healthy and happy after adjusting to the
new diet, says Hong Liu, the lead researcher on the project.
«For example, a non-blind
trial of a
new drug might conclude that it is way more effective than a placebo, when in fact the drug's true effect is rather modest, simply because the researchers» expectations biased the
results.»
The paper also reflects the diminished role
of aspirin in AF stroke prevention guidelines, various improvements in angioplasty / stent technology, and the
results of new randomised
trials including WOEST.
In 2011, Science's editors will be watching a smaller detector at the Large Hadron Collider called LHCb, which will study B mesons in great detail;
new techniques that should lead to the discovery
of many more genes contributing to adaptation; an ignited fusion burn at the National Ignition Facility; broadly neutralizing antibodies, which are capable
of disabling a wide range
of viral variants; the first plug - in hybrid electric cars whose batteries are charged from a wall socket go on the market; and the
results of the first phase III
trial of a malaria vaccine.
Results of a
new survey reveal that most cancer patients don't realize that participation in a clinical
trial is a treatment option.
The
results of the phase III clinical
trial were published November 29, 2017 in the
New England Journal
of Medicine.
«
New report calls into question effectiveness
of pregnancy anti-nausea drug: Researchers reanalyze clinical
trial results reported in 2010.»
Among the
new voluntary efforts by pharmaceutical companies to post clinical
trial data, the Association
of the British Pharmaceutical Industry, one
of the trade groups behind last week's proposal, will recommend that its members post
trial results on a World Health Organization (WHO) global
trials database that WHO hopes to establish in July.
What most encourages Black, in addition to the
new breakthrough in blood - brain barrier research, are the
results of a Phase 1 clinical
trial of an anticancer vaccine that began at the institute in 1998.
The
new six - year study, «Cognitive enhancement therapy for adult autism spectrum disorder:
Results of an 18 - month randomized clinical
trial,» involved 54 adults and was led by Shaun Eack, Ph.D., M.S.W., Pitt's David E. Epperson Professor
of Social Work and Psychiatry, and Nancy Minshew, M.D., Pitt professor
of psychiatry and neurology.
The first -
of - its - kind study found the dual treatments to be safe and elicit a clinical response in patients, according to
new results from a phase I
trial to be presented at the AACR Annual Meeting 2015 on April 19.
«The promising safety
results of these early
trials set the stage for additional HCQ
trials in different cancers, and
trials involving
new autophagy inhibitors that are being developed by pharmaceutical companies,» said Amaravadi.
Tulane University researchers have developed a
new drug that is effective against non-severe cases
of malaria, according to
results from an FDA - supervised clinical
trial published in the latest issue
of The Lancet Infectious Diseases.
Pembrolizumab is set to become a
new option for first line treatment of patients with advanced lung cancer and high PD - L1 expression, according to the results of the phase III KEYNOTE - 024 trial presented at the ESMO 2016 Congress in Copenhagen and published in the New England Journal of Medici
new option for first line treatment
of patients with advanced lung cancer and high PD - L1 expression, according to the
results of the phase III KEYNOTE - 024
trial presented at the ESMO 2016 Congress in Copenhagen and published in the
New England Journal of Medici
New England Journal
of Medicine.
New clinical
trial results show that transplantation
of pancreatic islets — cell clusters that contain insulin - producing cells — prevents severe, potentially life - threatening drops in blood sugar in people with type 1 diabetes.
The
results of the
trial, which compared a combination
of checkpoint inhibitors ipilimumab and nivolumab against ipilimumab alone in previously untreated patients, were presented today at the 2015 Annual Meeting
of the American Association for Cancer Research and have been simultaneously published in the
New England Journal
of Medicine.
Although the publication
of results of clinical
trials carried out in the USA within 12 months
of their completion has been mandatory since 2007, an astoundingly high number
of Phase III radiotherapy
trials did not do so, according to
new research to be presented at the ESTRO 35 conference today (Saturday).
The
results of the Phase 3 clinical
trial were published in the
New England Journal
of Medicine.
New results from a clinical
trial involving more than 900 military veterans at high risk for keratinocyte carcinoma skin cancer provides evidence that using the generic skin cream fluorouacil 5 percent for two to four weeks may reduce the risk
of a squamous cell carcinoma (SCC) needing surgery by 75 percent within a year.