Sentences with phrase «reticulum cell»

Mice have a high incidence of Hodgkin's - like reticulum cell neoplasm at 18 months of age and pituitary tumors in old multiparous females.

Not exact matches

SV = Secretory vesicle; RER = Rough endoplasmic reticulum; BM = Basement membrane; MFG = Milk fat globule; CLD = Cytoplasmic lipid droplet; N = Nucleus; PC = Plasma cell; FDA = Fat - depleted adipocyte; TJ = Tight junction; GJ = Gap junction; D = Desmosome; ME = Myoepithelial cell.

When it reaches the brain, Zika virus infects neuronal stem cells, which will generate fewer neurons, and by inducing chronic stress in the endoplasmic reticulum, it promotes apoptosis, i.e. the early death of these neuronal cells.

They showed that ZIKV infection of cortical progenitors (stem cells for cortical neurons) controlling neurogenesis triggers a stress in the endoplasmic reticulum (where some of the cellular proteins and lipids are synthetized) in the embryonic brain, inducing signals in response to incorrect protein con - formation (referred to as «unfolded protein response»).

In the online issue of the journal Nature, the researchers report a new function of FAM134B in the constant renewal of the endoplasmic reticulum (ER), an important cell organelle.

This atrophy is prompted by metabolites that purge the muscle cells of mitochondria and sarcoplasmic reticulum (which provide energy and signals), according to the BMC Ecology research.

In this research, the scientists disturbed endoplasmic reticulum function by introducing saturated fatty acids into cells to induce lipotoxic stress.

Hypertension drug that protects cell from endoplasmic reticulum stress and preserves oligodendrocytes and myelin during inflammation

The UPR is triggered when the normal functions of the endoplasmic reticulum — the cell's largest organelle in charge of making and folding proteins — are compromised.

In separate experiments, when Rab32 rises in response to stress in the endoplasmic reticulum, or ER, several things happen: The nerve cell fibers (both axons and the message - receiving dendrites) are shorter, mitochondria are bulkier than normal and their numbers spike.

The researchers also examined BRAF mutant melanoma cell lines, and found that BRAF inhibition induced autophagy by way of an endoplasmic reticulum (ER) stress response.

Enamel defects can be caused by genetic mutations affecting either the STIM1 calcium sensor in the endoplasm reticulum or in the ORAI channel in the cell membrane.

The researchers found that when the cells were stressed, they quickly moved mRNAs from the endoplasmic reticulum to the cytosol.

In the case of cells, one such bad consequence is the accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER), the cell's protein - making factory.

They then separated the cells into two groups — those containing mRNAs associated with ribosomes on the endoplasmic reticulum, and those containing mRNAs associated with free - floating ribosomes in the neighboring fluid - filled space known as the cytosol.

The translocon is an endoplasmic reticulum membrane protein that has the dual ability to insert a newly synthesized polypeptide chain into a cell membrane or secrete it across a cell membrane.

By examining cell processes both in mice and in human cells, the researchers found out why: Re-esterification helps protect a key cell organelle called the endoplasmic reticulum (ER).

The problem with making blood stem cells proliferate outside the body is that the artificial growth gives rise to an accumulation of abnormal proteins in a part of the cell called the endoplasmic reticulum, ER.

An international group of researchers led by Professor Christoph Hess from the Department of Biomedicine at the University of Basel and University Hospital Basel have now found a structure that accounts for the rapid immunologic memory of particular immune cells (CD8 + memory T cells): these important memory cells form multiple connections between mitochondria — the powerhouses of cells — and the endoplasmic reticulum, the site of protein production.

Lead author Dr Chris Bakal, leader of the Dynamical Cell Systems Team at The Institute of Cancer Research, London, said: «The endoplasmic reticulum is the factory of our cells, creating the proteins and lipids needed for our cells to grow and proliferate.

«We have discovered the key role played by the TOR signalling pathway in driving the expansion of the endoplasmic reticulum, and sending a cell's factories into overdrive.

Top: Fruit fly cells showing the endoplasmic reticulum (blue), nucleus (red) and tubulin (green).

Bottom: Human epithelial cells from breast tissue showing the effects of endoplasmic reticulum stress (blue) which fills the entire cell structure.

A protein in the TOR signalling pathway, called SREBP, controls the flow of messages to the endoplasmic reticulum telling it to expand — and could allow cancer cells to produce enough proteins and lipids to fuel their non-stop growth.

This information flow may also be followed through the cell as it travels from the DNA in the nucleus, to the Cytoplasm, to the Ribosomes and the Endoplasmic Reticulum, and finally to the Golgi Apparatus, which may package the final products for export outside the cell.

Scientists at The Institute of Cancer Research, London, identified a molecular trigger responsible for ratcheting up activity of the endoplasmic reticulum (ER)-- the cellular factory that makes the building blocks cancer cells need to keep growing.

Their findings suggest that the protein plays a role in increasing stress on the endoplasmic reticulum, an organelle involved in transporting and processing materials within cells.

It turns out that neuropathic pain is triggered when the body experiences endoplasmic reticulum (ER) stress, a condition in which the production and transport of protein exceeds the cells» capacities, say researchers from the University of California, Davis.

When unfolded proteins amass, they stress the cell's endoplasmic reticulum.

Responsible for this is a diffusion barrier in the endoplasmic reticulum (a channel system within the cell that is for example important for protein synthesis and transport).

Starting in the late 1980s, their labs revealed steps in how the endoplasmic reticulum, the cell's factory for processing secreted and membrane proteins, deals with proteins whose linear sequence of amino acids hasn't folded into a proper 3D shape.

Specifically, under stress, caused by uncontrolled ingestion of fats for example, the endoplasmic reticulum — a cell organelle associated with protein synthesis and folding and lipid metabolism — stops its activity in order to re-establish cell equilibrium.

They homed in on the function of the endoplasmic reticulum (ER)-- a «mini-organ» inside cells where proteins and lipids are processed and packaged and undergo quality control before they reach their destinations in the body.

Lung fibrosis is thought to also come about when the endoplasmic reticulum (ER) in the cells of the lung becomes stressed and can no longer properly fold and unfold proteins.

His laboratory currently applies high throughput imaging technologies to study trafficking between the endoplasmic reticulum and Golgi complex, and the internalization pathways taken by synthetic nanoparticles on exposure to cells.

When the research team used pharmaceuticals to inhibit one function of the endoplasmic reticulum (the building of so - called lipoprotein particles that will export fats out of the cell), the gene activation process was inhibited for many key genes and nuclear ruffling was also altered.

A conserved motif for the transport of G protein - coupled receptors from the endoplasmic reticulum to the cell surface.

Di - acidic Motifs in the Membrane - distal C Termini Modulate the Transport of Angiotensin II Receptors from the Endoplasmic Reticulum to the Cell Surface.

Role of endoplasmic reticulum calcium stores in beta - cell ER stress and lipotoxicity.

Glucose and endoplasmic reticulum calcium channels regulate HIF - 1β via presenilin in pancreatic β - cells.

Junctophilin - 4, a component of the endoplasmic reticulum — plasma membrane junctions, regulates Ca2 + dynamics in T cells.

Ca2 + pulsation in BY - 2 cells and evidence for control of mechanosensory Ca2 + - selective channels by the plasmalemmal reticulum.

Targeting IL - 2 to the endoplasmic reticulum confines autocrine growth stimulation to NK - 92 cells.

Pro-apoptotic bax and bak control beta - cell death and early endoplasmic reticulum stress signalling.

The Potato virus X TGBp2 protein association with the endoplasmic reticulum plays a role in but is not sufficient for viral cell - to - cell movement.

Endoplasmic reticulum - resident heat shock protein 90 (HSP90) isoform glucose - regulated protein 94 (GRP94) regulates cell polarity and cancer cell migration by affecting intracellular transport.

Distinct Pathways for the Trafficking of Angiotensin II and Adrenergic Receptors from the Endoplasmic Reticulum to the Cell Surface.

Confocal cryomicroscopic analysis and cryodynamics of endoplasmic reticulum in herbaceous plant cells.

STAT1 activation causes translocation of Bax to the endoplasmic reticulum during the resolution of airway mucous cell hyperplasia by IFN - γ.

α2B - adrenergic receptor interaction with tubulin controls its transport from the endoplasmic reticulum to the cell surface.