Not exact matches
The researchers focused on the mitochondria - associated membrane (MAM), which is a
contacting site of mitochondria and endoplasmic
reticulum (ER).
They counted each of the
contact points between two cellular organelles — the endoplasmic
reticulum (ER) and mitochondria — and demonstrated for the first time that the number of these connections, called MAMs, markedly increase during obesity.
Chronic enrichment of hepatic endoplasmic
reticulum - mitochondria
contact leads to mitochondrial dysfunction in obesity.
Tim initially found a lipid transfer protein that localised to a
contact site, and showed that it bound to the endoplasmic
reticulum (ER) protein VAP via a motif he named the FFAT motif.