As a loss of diameter
of retinal blood vessels is one of the features that is looked for in the early detection of PRA in eye examinations, this can complicate early diagnosis.
IDx - DR studied over 1 million eye images to learn how to recognize symptoms of diabetic retinopathy, a condition that develops when high blood sugar
damages retinal blood vessels (SN Online: 6/29/10).
«Our analysis suggests treatment of the retina with a large number of very small laser burns could prevent this «domino - like» progressive loss of
small retinal blood vessels and prevent elevation of VEGF and the major complications of diabetic retinopathy,» Dr. Gast said.
To do this we need to understand how this mechanism works normally, so we will test this therapeutic approach using an animal model where the pathway regulating
normal retinal blood vessel growth has been removed genetically.
Researchers then looked to see if the restricted blood flow caused by preeclampsia and changes in oxygen levels had any effect on weight gain or development of abnormal
retinal blood vessel growth.
These findings support the idea that those pups that are strong enough to survive induced preeclampsia may be stressed enough to induce growth factors necessary to increase normal
retinal blood vessel development and reduce ROP severity.
Every year thousands of children in Sweden are screened for ROP, a disease that afflicts extremely premature babies
whose retinal blood vessels have not fully developed.
Among their additional work in animal models, the scientists showed that diabetic rats that received human DME fluid high in PKal - related proteins but low in VEGF developed increased leakage
from retinal blood vessels.
To distinguish between a normal dog that has less
prominent retinal blood vessels and a dog with blood vessel thinning due to PRA the ophthalmologist looks for the presence of early retinal thinning.»
«Our analysis suggests treatment of the retina with a large number of very small laser burns could prevent this «domino - like» progressive loss of
small retinal blood vessels and prevent elevation of VEGF and the major complications of diabetic retinopathy,» Gast said.
(Rubbing his eye, he had torn
a retinal blood vessel, flooding the vitreous cavity with blood and making it seem, he says, «like I was lookin'through a stained - glass window with water runnin» down it.»)
The second, intermediate layer of
the retinal blood vessels seems to activate during periods of low oxygen and acts as a «reserve» of blood vessels in the retina.
«Our study presents an unexpected finding that the connections between cells in
the retinal blood vessels contain unusual, long - chain lipids that may keep vessels from leaking, possibly preventing diabetic retinopathy from occurring,» said Julia Busik, lead author of the study and a physiology professor.
Lead author of the study is physiology professor Julia Busik and she says: «Our study presents an unexpected finding that the connections between cells in
the retinal blood vessels contain unusual, long - chain lipids that may keep vessels from leaking, possibly preventing diabetic retinopathy from occurring.»
When the ophthalmologist views the retina with an instrument called an indirect ophthalmoscope, changes can be seen in
the retinal blood vessel pattern, the optic nerve and the tapetum (the reflective portion of the eye that is responsible for «eyeshine»).
Veterinary ophthalmologists who examine dogs with PRA will see a decrease in the size and number of
the retinal blood vessels and a change in the reflectivity of the tapetum (the shinny membrane behind the retina).