Sentences with phrase «retinal cell classes»

However, when forced to express the eye field transcription factor (EFTF) genes, the cells differentiate into all seven retinal cell classes and eventually organize themselves into a functioning eye that can detect light and guide tadpoles in a vision - based behavior.

Induced retinal cells differentiate into functional retinal cell classes and form a neural network sufficient for vision.

Markers were used to detect retinal cell classes.

These results suggest that EFTF - expressing cells are multipotent, as they differentiate into the seven retinal cell classes of the mature retina.

Retinal cell classes were identified based on their morphology, location within the retina, and using cell class specific markers (Figures 5 and S2, S3, S4, S5, S6).

When overexpressed together in developing Xenopus embryos by RNA microinjection, these genes can induce eye - like structures as defined by the expression of markers for some retinal cell classes [7].

All retinal cell classes are generated from a common multipotent retinal progenitor.

Noggin is a key component in the cocktail used to bias human ES cells to a retinal lineage, and we found it was also sufficient to direct Xenopus pluripotent cells to retinal cell classes and eventually functional eyes.

The expression patterns of cell class - specific markers in mosaic retinas appeared the same in host and donor derived regions suggesting that donor cells generated all retinal cell classes in approximately normal ratios (Figures 5K — 5N and S2).

These results suggest the fate of pluripotent cells may be purposely altered to generate multipotent retinal progenitor cells, which differentiate into functional retinal cell classes and form a neural circuitry sufficient for vision.

We used immunofluorescence and in situ hybridization to detect specific retinal cell classes.

Here we provide evidence that these pluripotent cells misexpressing the EFTFs differentiate into all retinal cell classes.

Molecular markers for seven retinal cell classes and peripherally located mitotic cells were detected in flank retinas.

EFTF - expressing pluripotent cells form functional retinal cells and eyes when transplanted to the developing embryo, but can these induced retinal cells also differentiate into all the functional retinal cell classes in a mature normal or damaged retinal environment?

Future studies can now address how to maintain induced retinal cell cultures in a proliferative, multipotent state and drive them to all the retinal cell classes necessary to repair a damaged or degenerating mature retina.

The overall aim of this study was to determine if pluripotent cells overexpressing these transcription factors could be intentionally driven toward retinal progenitors that differentiate into multiple retinal cell classes and form a functional retina.

If the EFTFs induce multipotent retinal progenitor cells, every retinal cell class, including retinal stem cells, should form in induced eyes.

Not exact matches

Bypassing damaged retinal cells The light - sensitive photoreceptors made by the rod and cone cells in the retina also belong to the GPCR class.

Most RGCs don't respond to light, but it turned out that the melanopsin - containing ones do, making them a brand - new class of previously unknown light - responsive retinal cells.

The reprogrammed cells formed all seven classes of retinal cells normally found in the eyes, including the retinal ganglion cells, which have axons (optic nerves) that extend to the brain.

Pluripotent stem cells — those, like embryonic stem cells, that give rise to almost every type of cell in the body — can be converted into the different classes of retinal cells necessary for vision, according to a new, RPB - supported study from researchers at SUNY Upstate Medical University in Syracuse, N.Y.

However, the evidence from the past decade or so has revealed a third class of photoreceptor within the eye; intrinsically photosensitive retinal ganglion cells (ipRGCs), which express their own distinct opsin — melanopsin [6,7].