Sentences with phrase «retinal cell lineage»

These results suggest that by using the correct combination of gene products, it may be possible to reprogram more readily available pluripotent cell types to a multipotent retinal cell lineage useful in healing damaged or diseased retinas.

These results suggest EFTF - expressing pluripotent cells share a common transcriptional profile with the eye field, and are consistent with the hypothesis that the EFTFs direct nonretinal pluripotent cells to an eye field - like retinal cell lineage.

Not exact matches

Not all donor cells were reprogrammed to a retinal lineage by the EFTFs.

These results suggest that Noggin, similar to the EFTFs it induces, directs pluripotent cells to a multipotent retinal progenitor lineage.

When transplanted to the mouse retina, human ES cells directed to a retinal lineage partially restore light - elicited ERG responses [5].

The second step will be to optimize culture conditions for the commitment of the iPS / hES cell - derived retinal precursors towards the photoreceptor lineage.

Cultured mouse, monkey, and human pluripotent cells can be driven down a retinal lineage as determined by the expression of marker genes, including the EFTFs [2]--[4].

Induced retinal cells were committed to a retinal lineage as they formed eyes when transplanted to the flanks of developing embryos.

Noggin is a key component in the cocktail used to bias human ES cells to a retinal lineage, and we found it was also sufficient to direct Xenopus pluripotent cells to retinal cell classes and eventually functional eyes.

When transplanted to the subretinal space of mice lacking functional photoreceptors, human embryonic stem cells directed toward a retinal lineage integrate into the outer nuclear layer, express photoreceptor markers, and restore a light response as determined by the electroretinogram (ERG)[5].