Sentences with phrase «retinal hypoxia»

Harris et al. [2] also provided evidence of the presence of retinal hypoxia in the early stages of diabetes by showing that contrast sensitivity was improved when patients with early diabetic retinopathy were made hyperoxic.

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The expression of a few retinal mRNAs known to be induced by hypoxia, including HIF - 1α, was assessed by qRT — PCR analysis of total RNA isolated from retinal tissue following exposure to 3 h of 6 % — 7 % O2.

In most cases, hypoxia is caused by either a dysfunction of the retinal vasculature, as in diabetic retinopathy and retinal artery and vein occlusions, or it is due to a mismatch between nutrient supply and demand, as in the case of a retinal detachment, where the retina is separated too far from the choroid to receive sufficient oxygen.

Insight into the novel role that NMDA receptors play in retinal responses to hypoxia may be derived from study of the coordinated expression patterns of genes that interact, either directly or indirectly, with the NMDA receptor; namely, the NMDA interactome.

Chronic experimental hypoxia kills photoreceptors in adult rat retina [14] and can lead to retinal angiogenesis [15].

Conclusions: The identification of gene expression alterations as a function of hypoxia and recovery from hypoxia is important to understand the molecular mechanisms underlying retinal dysfunction associated with a variety of diseases.

Little is known about the molecular effects of hypoxia on the retina and the underlying relationship between hypoxia and the pathogenesis of retinal diseases.

Some evidence of the involvement of retinal tissue hypoxia has come from in vivo measurements in animal models of disease, though the onset of hypoxia and the severity of the insult have been difficult to identify.

Park, Y. S., Kim, N. H. & Jo, I. Hypoxia and vascular endothelial growth factor acutely up - regulate angiopoietin - 1 and Tie2 mRNA in bovine retinal pericytes.