Sentences with phrase «retinoids against breast»

Previous trials of retinoids against breast cancer have been conducted only after anti-estrogen treatments, at which point, «we were already getting expansion of cancer stem cells — treating with a retinoid after that was already too late,» Fettig says.

Previous work has shown that retinoic acid, a chemical that results from the body's natural breakdown of vitamin A, should act against these CK5 + cells, but clinical trials of retinoids against breast cancer have been largely unsuccessful.

Now a University of Colorado Cancer Center study published online ahead of print in the journal Oncogene offers compelling evidence explaining this failure and offering a possible strategy for the use of retinoic acid or other retinoids against some breast cancers: Because early clinical trials are often offered to patients who have already tried other more established therapies, breast cancer cells may have been pushed past an important tipping point that offers retinoic acid resistance.