In addition to assessing
clinical outcomes in a
retrospective cohort of 30,000 children, the researchers studied a prospective
cohort of 2,472 children, doing telephone interviews with caregivers to measure outcomes that parents had identified as their highest concerns: adverse drug effects, additional childcare costs, lingering symptoms and missed school days.
Second, diagnoses of MDD were made prospectively, thus eliminating problems associated with long - term
retrospective recall.48 Third, diagnoses of MDD were made in a birth
cohort as opposed to a
clinical sample.