The patients were followed for 90 days, after which the researchers found significant reductions in coronary
revascularization procedures, fewer hospital readmissions and fewer recurrent cardiac testing episodes or the need for additional testing.
We don't know if there were differences in cardiac - related issues, such as heart attacks, recurrent angina, need for repeat
coronary revascularization procedures, or long - term readmissions for acute coronary syndromes,» said Dr. Lazar.
Clinical use of cerebrovascular compliance imaging to evaluate
revascularization in patients with moyamoya Watchmaker JM, Frederick BD, Fusco MR, Davis LT, Juttukonda MR, Lants SK, Kirshner HS, Donahue MJ.
A combination therapy of
endovascular revascularization plus supervised exercise may be beneficial, but few data comparing the two therapies are available, according to background information in the article.
«The results of the Penumbra 3D Trial speak positively on the use of Penumbra's 3D
Revascularization Device in combination with the Penumbra System aspiration devices, as well as on the use of Penumbra System aspiration devices alone,» said Donald Frei, MD, lead investigator of the study and director, NeuroInterventional Surgery at Radiology Imaging Associates / Swedish Medical Center in Englewood, Colorado.
«The trial results are encouraging for our Penumbra
3D Revascularization Device, and we are focused on continuing our plan to pursue regulatory submission by the end of this year,» said Adam Elsesser, chairman and chief executive officer of Penumbra.
â $ œFAME 2 showed that the strategy of treating stable ischemic heart disease with FFR - guided coronary stenting reduces the combination of death, MI and
urgent revascularization as compared with strategy of medical therapy alone, â $ Mavromatis says.
The primary endpoint was 30 - day net adverse clinical events (NACE), a composite of major adverse cardiac and cerebral events (MACCE; all - cause death, reinfarction, ischemia - driven target
vessel revascularization, or stroke) or any bleeding as defined by the Bleeding Academic Research Consortium (BARC) definition.
In addition, the researchers found patients receiving angioplasty were twice as likely to need
repeat revascularization and more than 1.8 times as likely to have a heart attack as patients who received bypass.
The patients were also CCS angina class II - IV and / or NYHA class II - III, had ongoing ischemia and multi-vessel cardiovascular disease, but were not candidates
for revascularization.
Because most patients with ischemic mitral regurgitation have multivessel coronary artery disease
requiring revascularization, surgeons have to consider whether to add mitral - valve repair to coronary - artery bypass grafting (CABG).
«Stroke Care: Randomized penumbra 3 - D trial of next generation stent retriever meets primary endpoints: Data also highlight frontline effectiveness of aspiration using Penumbra System for
stroke revascularization.»
In fact, after follow - up (2.5 to 3.1 years), there were a total of 216 adverse events reported among study participants including 108 deaths, of which 27 were cardiovascular, plus 34 heart attacks, 30 strokes, 18 experienced unstable angina and hospitalized, and 79
needed revascularization procedures.
However, women are less likely to receive proven therapies than men, including aspirin, statins, coronary
revascularization after an acute coronary event (8) and oral anticoagulants to prevent stroke when they have atrial fibrillation, despite their higher risk.
8 percent of patients with no calcium went on to
receive revascularization to restore blood flow to the heart, compared to 6.5 percent of patients who had calcium in their coronary arteries.
When revascularization was added to the total cardiovascular disease outcome variable, the risk estimates were reduced for both men and women, but remained significant.
In addition, the more strictly
defined revascularization measure, TICI 2b / 3, showed non-inferiority between the 3D + aspiration device arm and the aspiration device - only arm (83.9 percent vs 74.1 percent).
â $ œThis benefit was specifically due to the reduced need of urgent
revascularization due to acute coronary syndrome, a dramatic event for our patients.â $
ASCs isolated from the stromal vascular fraction of fat have advantages over other mesenchymal stem cell sources; they are easy to isolate and expand and aid in the repair of damaged tissues [7], including islet graft survival and revascularization [8].
«It is true that drug - eluting stents are more expensive that bare - metal stents, but that may be offset by the cost of
added revascularization procedures required for patients with bare - metal versions,» he added.
Patients who received a drug - eluting stent did, as expected, have less need for a
second revascularization procedure, but not to the level surgeons might have expected, Bonaa said.
Tully PJ, Winefield HR, Baker RA, Turnbull DA, de Jonge P (2011) Confirmatory factor analysis of the Beck Depression Inventory - II and the association with cardiac morbidity and mortality after coronary
revascularization J Health Psychol 16: 584 595
Penumbra, Inc. (NYSE: PEN), a global interventional therapies company, has announced that the Penumbra 3D Trial successfully met the primary trial endpoints, demonstrating non-inferiority in both safety and efficacy of the company's next - generation stent retriever, Penumbra 3D
Revascularization Device, when used with Penumbra System aspiration devices compared to Penumbra System aspiration devices alone.
Two other multi-national trials randomized 27,438 patients to either bococizumab or placebo and were designed to evaluate the impact of the drug on cardiovascular outcomes, including nonfatal heart attack and stroke, hospitalization for unstable angina requiring
urgent revascularization, or cardiovascular death.
In fact, «thirty patients would need to be treated with drug - eluting stents rather than with bare - metal stents to prevent one
repeat revascularization,» he said.
Overall rates of
revascularization procedures were low in each group, he noted: 16.5 percent in the drug - eluting stent group versus 20 percent in the bare - metal stent group.
«During this relatively long - term follow - up, angioplasty was associated with a significant increase in the incidence of the death, myocardial infarction and target vessel
revascularization, a difference that was mainly attributed to the higher rate of target - vessel revascularization in the angioplasty group,» Park said.
However, responses to cardiac injury repair in the outer layer of the heart (epicardium) and blood vessels (
revascularization)-- were present.
The authors measured the proportion of patients in each group who received cardiac catheterization, a coronary
revascularization procedure or future noninvasive test, as well as those hospitalized for heart attack (acute myocardial infarction, MI).
The study showed that compared with no testing, EE, MPS and CCTA were associated with higher odds of undergoing cardiac catheterization and
revascularization procedures without an accompanying improvement in the odds of having a heart attack.
When compared to women who did not have migraine, these results show that women who reported a migraine had a greater risk for major cardiovascular disease, including heart attacks, strokes and angina / coronary
revascularization procedures.
Participants subsequently reported any interim physician - diagnosed events including myocardial infarction, stroke, and
revascularization.
There were 3,300 and 2,148 total cardiovascular disease cases (myocardial infarction, stroke, and
revascularization) in the Nurses» Health Study and the Health Professionals Follow - Up Study, respectively.
Nevertheless, the risk of adverse outcomes remains substantial, and there is no consensus on a single optimal injectable anticoagulant that can be used across the continuum of care from the emergency setting through
revascularization (when applicable),» according to background information in the article.
The patients were followed up through provincial health administrative data (Ontario, Canada) until May 2011 for CV disease (myocardial infarction, stroke, congestive heart failure,
revascularization procedures) and death from any cause, analyzed as a composite outcome.
M.G. Myriam Hunink, M.D., Ph.D., of the Erasmus University Medical Center, Rotterdam, the Netherlands, and colleagues randomly assigned 212 patients with PAD and intermittent claudication to endovascular
revascularization plus supervised exercise (n = 106) or supervised exercise only (n = 106).
The researchers found that endovascular
revascularization plus supervised exercise (combination therapy) was associated with greater improvement in maximum walking distance compared with the supervised exercise only group, and in pain - free walking distance.
«The present study reopens the debate for
revascularization in patients with claudication, in particular in terms of an approach using endovascular revascularization first.