Now, MIT engineers have developed a far more sensitive way to
reveal ovarian tumors: In tests in mice, they were able to detect tumors composed of nodules smaller than 2 millimeters in diameter.
Not exact matches
The resulting «map» of gene - drug interactions allowed the researchers to accurately predict the responses of multiple human cancer cell lines to different chemotherapy agents based on the cell lines» genetic profiles and also
revealed new genetic factors that appear to determine the response of breast and
ovarian tumor cells to common classes of chemotherapy treatment.
In addition, the study, led by investigators in The Cancer Genome Atlas (TCGA) Research Network,
revealed four novel
tumor subtypes, while also identifying genomic similarities between endometrial and other cancer types, including breast,
ovarian, and colorectal cancers.
He previously
revealed the existence of spontaneous immune responses in
ovarian tumors as well as described how regulatory T cells and
tumor blood vessels affect these responses.
«Finding genomic similarities among types of breast,
ovarian, endometrial and colorectal
tumors once again
reveals that cancer, although very complex, may have themes extending beyond tissue type that can be exploited for therapeutic benefit,» said Eric D. Green, M.D., Ph.D., NHGRI director.
Studies conducted that year
revealed that 75 percent of
ovarian tumors studied contained talc particles.