«The organization of cell colonies and phenotypic switching between different types of colonies becomes a lot more flexible and rapid with
reversible aneuploidy than if it depended on random mutations in the genes,» Skupin says.
A low, non-genotoxic, dose (about 1 nM) of ActD has been shown to induce a
reversible cytostatic effect in normal proliferating dermal fibroblasts and protect them from the
aneuploidy induced by the aurora kinase inhibitor VX - 680 and the toxic effects of gemcitabine [46, 47].