Sentences with phrase «rewarding effects of the drug»
«Our goal was to discover the brain mechanisms responsible for the rewarding effects of the drug and the motivation to seek it even after long periods of abstinence,» says Cowan.
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Marijuana, like other drugs of abuse, stimulates brain dopamine (DA) signaling in the nucleus accumbens (1, 2), which is a mechanism believed to underlie the rewarding effects of drugs (3 ⇓ — 5) and to trigger the neuroadaptations that result in addiction (reviewed in ref.
Not exact matches
«Over time, the effect on the reward centre in the brain is similar to what makes drug addicts go back for another line of cocaine.»
Volkow walked through how the analgesic and rewarding effects of opioids are expressed in pain terminals in the spinal cord and in the brain where the drugs impact regions that regulate reward and pleasure.
In people, addictive drugs desensitise the brain by raising the threshold of «reward» activity that is needed to feel satisfied: more drug is needed to achieve the same effect.
Giving the bees a drug to block the neurochemical dopamine, which is related to the reward system in humans, largely reversed the effects of the treat, indicating that these effects were down to dopamine making them feel good.
«It's not just the positive, rewarding effects of cocaine that drive this desire to seek the drug» he said.
The reward - related, or «hedonic,» component is centralized in the mesolimbic dopamine system, areas of the brain usually referenced when we talk about the effects of sex, drugs and rock»n' roll.
Moreover, rats rejected drink rewards spiked with insulin - blocking drugs in favor of drinks that let them feel insulin's effects.
They analyzed the drugs» effects on the release of dopamine, a neurotransmitter that evokes feelings of pleasure and reward, in a region of the brain known as the nucleus accumbens.
Opiate addiction is largely controlled by the formation of powerful reward memories that link the pleasurable effects of opiate - class drugs to environmental triggers that induce drug craving in individuals addicted to opiates.
More recently, Dr. Parsons has explored the involvement of endogenous cannabinoid signaling in the rewarding effects of abused drugs.
Dr. Parsons has provided similar insights into the mechanisms through which endocannabinoids modulate the rewarding effects of opiates, alcohol, and cocaine, and he is presently extending his evaluations of this stage of the addiction cycle to include animal models of commonly occurring genetic polymorphisms that are associated with problematic drug use and dependence in humans.
While the subjective effects of nicotine and cocaine are very different in humans, the overlapping effects of the two drugs on the reward system of the brain may explain why both are highly addictive substances, the researchers said.
Neurons that originate in the VTA release the neurotransmitter dopamine, known to play a central role in the effects of addictive drugs and natural rewards such as food and sex.
«Early exposure to nicotine primes the brain to the rewarding effects of other drugs.
As smoking in our country has gone down, that may have served to prevent the rewarding effects of other drugs.»
Since the identical brain «reward pathways» are used by both types of drugs, they can be equally addictive and also may cause side effects like memory loss, hip fractures, impaired thinking, and dizziness.
Animal studies show oxytocin can boost the reward of social connection, lower the effect of drugs, reduce anxiety, and improve management of stressors.