According to the FDA, cobimetinib may cause severe side effects
including cardiomyopathy or
rhabdomyolysis, primary cutaneous malignancies, retinal detachment, hepatotoxicity, hemorrhage, and severe skin rash due to increased sensitivity to sunlight.
Complications may
include heart attack, stroke, muscle disintegration (
rhabdomyolysis), acute lung damage, collapse or coma
Other side effects may
include aggression, altered serum creatinine levels, anorexia, anxiety, burping, confusion, constipation, depression, drowsiness, elevated liver enzymes, fainting, fever, headaches, heat intolerance, increased cortisol or insulin levels, increased symptoms of deep vein thrombosis, jaundice, lightheadedness, liver injury, mania, metabolic acidosis, myopathy (muscle disease),
rhabdomyolysis (muscle breakdown), seizures, skin rashes, vomiting, worsening sleep problems, yellowing of the skin irregular heart rhythm (arrhythmia) and pigmented purpuric dermatosis [3,6].